Poor Cortical Venous Opacification on Baseline Computed Tomography Angiography Predicts Parenchymal Hemorrhage After Thrombectomy
Background Although the association between cortical venous opacification (VO) and clinical outcomes has been shown in previous studies, little is known about the relationship between parenchymal hemorrhage (PH) and VO in patients with acute stroke. We aimed to determine whether cortical VO assessed...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-11-01
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| Series: | Stroke: Vascular and Interventional Neurology |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/SVIN.121.000299 |
| _version_ | 1797844128474595328 |
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| author | Fouzi Bala Nishita Singh Bijoy K. Menon Andrew M. Demchuk Alexandre Y. Poppe Ryan A. McTaggart Raul G. Nogueira Brian H. Buck Mayank Goyal Michael D. Hill Mohammed A. Almekhlafi |
| author_facet | Fouzi Bala Nishita Singh Bijoy K. Menon Andrew M. Demchuk Alexandre Y. Poppe Ryan A. McTaggart Raul G. Nogueira Brian H. Buck Mayank Goyal Michael D. Hill Mohammed A. Almekhlafi |
| author_sort | Fouzi Bala |
| collection | DOAJ |
| description | Background Although the association between cortical venous opacification (VO) and clinical outcomes has been shown in previous studies, little is known about the relationship between parenchymal hemorrhage (PH) and VO in patients with acute stroke. We aimed to determine whether cortical VO assessed on computed tomography angiography correlates with the risk of PH following endovascular treatment. Methods This is a post hoc analysis of the ESCAPE NA‐1 (Efficacy and Safety of Nerinetide in Subjects Undergoing Endovascular Thrombectomy for Stroke) trial. Control‐arm patients with adequate venous assessment on computed tomography angiography were included. Any PH and symptomatic intracranial hemorrhage were compared between patients with poor VO (cortical vein opacification score<3) versus good opacification (cortical vein opacification score≥3). The relationships with unfavorable functional outcome (90‐day modified Rankin scale 3–6) and 24‐hour infarct volume were assessed. Multivariable logistic and linear regressions were performed. Results Among the 545 patients that met the inclusion criteria, 55 (10.2%) had PH and 21 (3.9%) had symptomatic intracranial hemorrhage. Poor VO was observed in 286 (52.5%) patients (median age, 71 years; 51.4% women). PH was more frequent in the patients with poor VO compared with good VO: 43 of 283 (15.2%) versus 12 of 257 (4.7%) (adjusted odds ratio, 3.43; [95% CI, 1.66–7.10]). Symptomatic intracranial hemorrhage was not significantly higher in the poor versus good opacification groups: 14 of 283 (5.0%) versus 7 of 257 (2.7%). Poor opacification was a predictor of unfavorable functional outcome (adjusted odds ratio, 3.01; [95% CI, 1.95–4.64]; P<0.001), and larger final infarct volume (adjusted B 0.74; [95% CI, 0.45–1.03]; P<0.001). Conclusions Poor VO on computed tomography angiography is strongly associated with an increased risk of PH and worse clinical outcomes after endovascular treatment, and therefore it may be used as a tool for risk stratification in patients with stroke. |
| first_indexed | 2024-04-09T17:17:21Z |
| format | Article |
| id | doaj.art-80b2001d468449f78a18ba31d930ce01 |
| institution | Directory Open Access Journal |
| issn | 2694-5746 |
| language | English |
| last_indexed | 2024-04-09T17:17:21Z |
| publishDate | 2022-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stroke: Vascular and Interventional Neurology |
| spelling | doaj.art-80b2001d468449f78a18ba31d930ce012023-04-19T11:15:14ZengWileyStroke: Vascular and Interventional Neurology2694-57462022-11-012610.1161/SVIN.121.000299Poor Cortical Venous Opacification on Baseline Computed Tomography Angiography Predicts Parenchymal Hemorrhage After ThrombectomyFouzi Bala0Nishita Singh1Bijoy K. Menon2Andrew M. Demchuk3Alexandre Y. Poppe4Ryan A. McTaggart5Raul G. Nogueira6Brian H. Buck7Mayank Goyal8Michael D. Hill9Mohammed A. Almekhlafi10Department of Clinical Neurosciences, Cumming School of Medicine University of Calgary and Foothills Medical Centre Calgary AB CanadaDepartment of Clinical Neurosciences, Cumming School of Medicine University of Calgary and Foothills Medical Centre Calgary AB CanadaDepartment of Clinical Neurosciences, Cumming School of Medicine University of Calgary and Foothills Medical Centre Calgary AB CanadaDepartment of Clinical Neurosciences, Cumming School of Medicine University of Calgary and Foothills Medical Centre Calgary AB CanadaCentre Hospitalier de l'Université de Montréal Montreal Quebec CanadaDepartment of Interventional Radiology Warren Alpert Medical School of Brown University Providence RIDepartment of Neurology Emory University School of Medicine Atlanta GADepartment of Medicine University of Alberta Hospital Edmonton CanadaDepartment of Clinical Neurosciences, Cumming School of Medicine University of Calgary and Foothills Medical Centre Calgary AB CanadaDepartment of Clinical Neurosciences, Cumming School of Medicine University of Calgary and Foothills Medical Centre Calgary AB CanadaDepartment of Clinical Neurosciences, Cumming School of Medicine University of Calgary and Foothills Medical Centre Calgary AB CanadaBackground Although the association between cortical venous opacification (VO) and clinical outcomes has been shown in previous studies, little is known about the relationship between parenchymal hemorrhage (PH) and VO in patients with acute stroke. We aimed to determine whether cortical VO assessed on computed tomography angiography correlates with the risk of PH following endovascular treatment. Methods This is a post hoc analysis of the ESCAPE NA‐1 (Efficacy and Safety of Nerinetide in Subjects Undergoing Endovascular Thrombectomy for Stroke) trial. Control‐arm patients with adequate venous assessment on computed tomography angiography were included. Any PH and symptomatic intracranial hemorrhage were compared between patients with poor VO (cortical vein opacification score<3) versus good opacification (cortical vein opacification score≥3). The relationships with unfavorable functional outcome (90‐day modified Rankin scale 3–6) and 24‐hour infarct volume were assessed. Multivariable logistic and linear regressions were performed. Results Among the 545 patients that met the inclusion criteria, 55 (10.2%) had PH and 21 (3.9%) had symptomatic intracranial hemorrhage. Poor VO was observed in 286 (52.5%) patients (median age, 71 years; 51.4% women). PH was more frequent in the patients with poor VO compared with good VO: 43 of 283 (15.2%) versus 12 of 257 (4.7%) (adjusted odds ratio, 3.43; [95% CI, 1.66–7.10]). Symptomatic intracranial hemorrhage was not significantly higher in the poor versus good opacification groups: 14 of 283 (5.0%) versus 7 of 257 (2.7%). Poor opacification was a predictor of unfavorable functional outcome (adjusted odds ratio, 3.01; [95% CI, 1.95–4.64]; P<0.001), and larger final infarct volume (adjusted B 0.74; [95% CI, 0.45–1.03]; P<0.001). Conclusions Poor VO on computed tomography angiography is strongly associated with an increased risk of PH and worse clinical outcomes after endovascular treatment, and therefore it may be used as a tool for risk stratification in patients with stroke.https://www.ahajournals.org/doi/10.1161/SVIN.121.000299cerebral hemorrhageischemic strokestrokethrombectomy |
| spellingShingle | Fouzi Bala Nishita Singh Bijoy K. Menon Andrew M. Demchuk Alexandre Y. Poppe Ryan A. McTaggart Raul G. Nogueira Brian H. Buck Mayank Goyal Michael D. Hill Mohammed A. Almekhlafi Poor Cortical Venous Opacification on Baseline Computed Tomography Angiography Predicts Parenchymal Hemorrhage After Thrombectomy Stroke: Vascular and Interventional Neurology cerebral hemorrhage ischemic stroke stroke thrombectomy |
| title | Poor Cortical Venous Opacification on Baseline Computed Tomography Angiography Predicts Parenchymal Hemorrhage After Thrombectomy |
| title_full | Poor Cortical Venous Opacification on Baseline Computed Tomography Angiography Predicts Parenchymal Hemorrhage After Thrombectomy |
| title_fullStr | Poor Cortical Venous Opacification on Baseline Computed Tomography Angiography Predicts Parenchymal Hemorrhage After Thrombectomy |
| title_full_unstemmed | Poor Cortical Venous Opacification on Baseline Computed Tomography Angiography Predicts Parenchymal Hemorrhage After Thrombectomy |
| title_short | Poor Cortical Venous Opacification on Baseline Computed Tomography Angiography Predicts Parenchymal Hemorrhage After Thrombectomy |
| title_sort | poor cortical venous opacification on baseline computed tomography angiography predicts parenchymal hemorrhage after thrombectomy |
| topic | cerebral hemorrhage ischemic stroke stroke thrombectomy |
| url | https://www.ahajournals.org/doi/10.1161/SVIN.121.000299 |
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