Helicobacter pylori as a trigger and aggravating factor in rheumatoid arthritis and other rheumatic diseases

Helicobacter pylori is the most common human infection. H. pylori is known to cause chronic gastritis and gastric and duodenal ulcers. However, the H. pylori-host interaction is not confined to the gastric mucosa, the mechanism responsible for the adaptation of this bacterium to the living condition...

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Main Authors: A. O. Plakhova, E. S. Nikitina, V. N. Sorotskaya, A. E. Karateev
Format: Article
Language:Russian
Published: IMA-PRESS LLC 2017-04-01
Series:Современная ревматология
Subjects:
Online Access:https://mrj.ima-press.net/mrj/article/view/757
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author A. O. Plakhova
E. S. Nikitina
V. N. Sorotskaya
A. E. Karateev
author_facet A. O. Plakhova
E. S. Nikitina
V. N. Sorotskaya
A. E. Karateev
author_sort A. O. Plakhova
collection DOAJ
description Helicobacter pylori is the most common human infection. H. pylori is known to cause chronic gastritis and gastric and duodenal ulcers. However, the H. pylori-host interaction is not confined to the gastric mucosa, the mechanism responsible for the adaptation of this bacterium to the living conditions in the human body, can cause systemic immune imbalance, provoking various autoimmune reactions. The paper considers the investigations demonstrating the possible role of H. pylori as a trigger or aggravating factor in rheumatic diseases, such as rheumatoid arthritis (RA), Sjögren's syndrome and disease, systemic lupus erythematosus, and progressive systemic sclerosis. The relationship between H. pylori and autoimmune diseases is confirmed by the higher frequency of more aggressive strains of this microorganism in rheumatic diseases. There are also clinical trials showing the positive impact of H. pylori eradication on RA activity.
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spelling doaj.art-80b343c67e354c418065dd3ad3d25a102023-03-13T08:39:25ZrusIMA-PRESS LLCСовременная ревматология1996-70122310-158X2017-04-01112606710.14412/1996-7012-2017-2-60-672036Helicobacter pylori as a trigger and aggravating factor in rheumatoid arthritis and other rheumatic diseasesA. O. Plakhova0E. S. Nikitina1V. N. Sorotskaya2A. E. Karateev3ФГБОУ ВО «Тульский государственный университет», ТулаФГБОУ ВО «Тульский государственный университет», ТулаФГБОУ ВО «Тульский государственный университет», ТулаФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой», МоскваHelicobacter pylori is the most common human infection. H. pylori is known to cause chronic gastritis and gastric and duodenal ulcers. However, the H. pylori-host interaction is not confined to the gastric mucosa, the mechanism responsible for the adaptation of this bacterium to the living conditions in the human body, can cause systemic immune imbalance, provoking various autoimmune reactions. The paper considers the investigations demonstrating the possible role of H. pylori as a trigger or aggravating factor in rheumatic diseases, such as rheumatoid arthritis (RA), Sjögren's syndrome and disease, systemic lupus erythematosus, and progressive systemic sclerosis. The relationship between H. pylori and autoimmune diseases is confirmed by the higher frequency of more aggressive strains of this microorganism in rheumatic diseases. There are also clinical trials showing the positive impact of H. pylori eradication on RA activity.https://mrj.ima-press.net/mrj/article/view/757helicobacter pyloriаутоиммунные заболеваниясиндром шёгренаболезнь шёгренасистемная красная волчанкапрогрессирующий системный склерозревматоидный артритсиндром рейноактивность заболеванияэрадикация
spellingShingle A. O. Plakhova
E. S. Nikitina
V. N. Sorotskaya
A. E. Karateev
Helicobacter pylori as a trigger and aggravating factor in rheumatoid arthritis and other rheumatic diseases
Современная ревматология
helicobacter pylori
аутоиммунные заболевания
синдром шёгрена
болезнь шёгрена
системная красная волчанка
прогрессирующий системный склероз
ревматоидный артрит
синдром рейно
активность заболевания
эрадикация
title Helicobacter pylori as a trigger and aggravating factor in rheumatoid arthritis and other rheumatic diseases
title_full Helicobacter pylori as a trigger and aggravating factor in rheumatoid arthritis and other rheumatic diseases
title_fullStr Helicobacter pylori as a trigger and aggravating factor in rheumatoid arthritis and other rheumatic diseases
title_full_unstemmed Helicobacter pylori as a trigger and aggravating factor in rheumatoid arthritis and other rheumatic diseases
title_short Helicobacter pylori as a trigger and aggravating factor in rheumatoid arthritis and other rheumatic diseases
title_sort helicobacter pylori as a trigger and aggravating factor in rheumatoid arthritis and other rheumatic diseases
topic helicobacter pylori
аутоиммунные заболевания
синдром шёгрена
болезнь шёгрена
системная красная волчанка
прогрессирующий системный склероз
ревматоидный артрит
синдром рейно
активность заболевания
эрадикация
url https://mrj.ima-press.net/mrj/article/view/757
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AT vnsorotskaya helicobacterpyloriasatriggerandaggravatingfactorinrheumatoidarthritisandotherrheumaticdiseases
AT aekarateev helicobacterpyloriasatriggerandaggravatingfactorinrheumatoidarthritisandotherrheumaticdiseases