Forced Hepatic Expression of NRF2 or NQO1 Impedes Hepatocyte Lipid Accumulation in a Lipodystrophy Mouse Model

Forced Hepatic Expression of NRF2 or NQO1 Impedes Hepatocyte Lipid Accumulation in a Lipodystrophy Mouse Model

Lipodystrophy is a disorder featuring loss of normal adipose tissue depots due to impaired production of normal adipocytes. It leads to a gain of fat deposition in ectopic tissues such as liver and skeletal muscle that results in steatosis, dyslipidemia, and insulin resistance. Previously, we establ...

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Bibliographic Details
Main Authors: Nobunao Wakabayashi, Yoko Yagishita, Tanvi Joshi, Thomas W. Kensler
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:International Journal of Molecular Sciences
Subjects:
NRF2
NQO1
KEAP1
lipodystrophy
lipogenesis
hydrodynamic tail vein injection
Online Access:https://www.mdpi.com/1422-0067/24/17/13345

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