A single intranasal dose of chimpanzee adenovirus-vectored vaccine protects against SARS-CoV-2 infection in rhesus macaques

A single intranasal dose of chimpanzee adenovirus-vectored vaccine protects against SARS-CoV-2 infection in rhesus macaques

Summary: The deployment of a vaccine that limits transmission and disease likely will be required to end the coronavirus disease 2019 (COVID-19) pandemic. We recently described the protective activity of an intranasally administered chimpanzee adenovirus-vectored vaccine encoding a pre-fusion stabil...

Full description

Bibliographic Details
Main Authors:	Ahmed O. Hassan, Friederike Feldmann, Haiyan Zhao, David T. Curiel, Atsushi Okumura, Tsing-Lee Tang-Huau, James Brett Case, Kimberly Meade-White, Julie Callison, Rita E. Chen, Jamie Lovaglio, Patrick W. Hanley, Dana P. Scott, Daved H. Fremont, Heinz Feldmann, Michael S. Diamond
Format:	Article
Language:	English
Published:	Elsevier 2021-04-01
Series:	Cell Reports Medicine
Subjects:	vaccine SARS-CoV-2 immunity non-human primates immunogenicity mucosal
Online Access:	http://www.sciencedirect.com/science/article/pii/S266637912100046X

Similar Items

Malaria disrupts the rhesus macaque gut microbiome
by: Danielle N. Farinella, et al.
Published: (2023-01-01)

Delayed Disease Progression in Cynomolgus Macaques Infected with Ebola Virus Makona Strain
by: Andrea Marzi, et al.
Published: (2015-10-01)

Natural Norovirus Infections in Rhesus Macaques
by: Tibor Farkas
Published: (2016-07-01)

Correlates of Protection Against SIVmac251 Infection in Rhesus Macaques Immunized With Chimpanzee-Derived Adenovirus Vectors
by: Steven Tuyishime, et al.
Published: (2018-05-01)

Impact of sleep deprivation on neurocognition and inflammation in rhesus macaques
by: Wanwisa Promsote, et al.
Published: (2023-11-01)

The rhesus macaque as a success story of the Anthropocene
by: Eve B Cooper, et al.
Published: (2022-07-01)

Biophysical and Functional Characterization of Rhesus Macaque IgG Subclasses
by: Austin W. Boesch, et al.
Published: (2016-12-01)

Testosterone increases circulating dehydroepiandrosterone sulfate levels in the male rhesus macaque
by: Krystina eSorwell, et al.
Published: (2014-06-01)

Lack of Evidence for Microbiota in the Placental and Fetal Tissues of Rhesus Macaques
by: Kevin R. Theis, et al.
Published: (2020-06-01)

Natural history of Sudan ebolavirus infection in rhesus and cynomolgus macaques
by: Courtney Woolsey, et al.
Published: (2022-12-01)

The Impact of Aging on Brain Pituitary Adenylate Cyclase Activating Polypeptide, Pathology and Cognition in Mice and Rhesus Macaques
by: Pengcheng Han, et al.
Published: (2017-06-01)

Sex- and species-associated differences in complement-mediated immunity in humans and rhesus macaques
by: Natasha S. Kelkar, et al.
Published: (2024-03-01)

Correlation between Disease Severity and the Intestinal Microbiome in <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content>-Infected Rhesus Macaques
by: Sivaranjani Namasivayam, et al.
Published: (2019-06-01)

The Rhesus Macaque as a Translational Model for Neurodegeneration and Alzheimer’s Disease
by: Gail A. Stonebarger, et al.
Published: (2021-09-01)

Protection Against Marburg Virus Using a Recombinant VSV-Vaccine Depends on T and B Cell Activation
by: Andrea Marzi, et al.
Published: (2019-01-01)

Detection of Cyclospora in captive chimpanzees and macaques by a quantitative PCR-based mutation scanning approach
by: Marianna Marangi, et al.
Published: (2015-05-01)

Characterization of Rhesus Macaque Liver-Resident CD49a+ NK Cells During Retrovirus Infections
by: Daniel R. Ram, et al.
Published: (2020-07-01)

Longitudinal analysis of immunocyte responses and inflammatory cytokine profiles in SFTSV-infected rhesus macaques
by: Yi-Hui Li, et al.
Published: (2023-03-01)

Safety and preservation of cardiac function following therapeutic vaccination against Trypanosoma cruzi in rhesus macaques
by: Eric Dumonteil, et al.
Published: (2023-04-01)

Hydroxychloroquine prophylaxis and treatment is ineffective in macaque and hamster SARS-CoV-2 disease models
by: Kyle Rosenke, et al.
Published: (2020-12-01)

Pathogenicity and Viral Shedding of MERS-CoV in Immunocompromised Rhesus Macaques
by: Joseph Prescott, et al.
Published: (2018-02-01)

Distinct transcriptional responses to fatal Ebola virus infection in cynomolgus and rhesus macaques suggest species-specific immune responses
by: Amanda N. Pinski, et al.
Published: (2021-01-01)

UK B.1.1.7 (Alpha) variant exhibits increased respiratory replication and shedding in nonhuman primates
by: Kyle Rosenke, et al.
Published: (2021-01-01)

Population Scale Analysis of Centromeric Satellite DNA Reveals Highly Dynamic Evolutionary Patterns and Genomic Organization in Long-Tailed and Rhesus Macaques
by: Worapong Singchat, et al.
Published: (2022-06-01)

Multi-omics analysis reveals the host–microbe interactions in aged rhesus macaques
by: Jue Xu, et al.
Published: (2022-09-01)

Potentially Zoonotic Enteric Infections in Gorillas and Chimpanzees, Cameroon and Tanzania
by: Emily K. Strahan, et al.
Published: (2024-03-01)

Transmitted/founder SHIV.D replicates in the brain, causes neuropathogenesis, and persists on combination antiretroviral therapy in rhesus macaques
by: Rachel M. Podgorski, et al.
Published: (2023-08-01)

Assembly of novel microbial genomes from gut metagenomes of rhesus macaque (Macaca mulatta)
by: Shengzhi Yang, et al.
Published: (2023-12-01)

Particulate matter 10 induces oxidative stress and apoptosis in rhesus macaques skin fibroblast
by: Jiin Lee, et al.
Published: (2023-12-01)

Transplantation of Adult Monkey Neural Stem Cells into A Contusion Spinal Cord Injury Model in Rhesus Macaque Monkeys
by: Shiva Nemati, et al.
Published: (2014-06-01)

Rich Club Characteristics of Alcohol-Naïve Functional Brain Networks Predict Future Drinking Phenotypes in Rhesus Macaques
by: Jared A. Rowland, et al.
Published: (2021-06-01)

Pet Macaques in Vietnam: An NGO’s Perspective
by: Brooke Catherine Aldrich, et al.
Published: (2020-12-01)

Prevalence of gastrointestinal helminth parasites in rhesus macaques and local residents in the central mid-hills of Nepal
by: Tandan S., et al.
Published: (2023-12-01)

Astrocyte expression of aging-associated markers positively correlates with neurodegeneration in the frontal lobe of the rhesus macaque brain
by: Miranda D. Horn, et al.
Published: (2024-03-01)

Low <i>Aedes aegypti</i> Vector Competence for Zika Virus from Viremic Rhesus Macaques
by: Rosilainy Surubi Fernandes, et al.
Published: (2020-11-01)

Erythrocytes of the Rhesus and Cynomolgus Monkeys
by: Vincenzo Stingo
Published: (2019-10-01)

Rhesus macaque social functioning is paternally, but not maternally, inherited by sons: potential implications for autism
by: Joseph P. Garner, et al.
Published: (2023-07-01)

Yearly variation coupled with social interactions shape the skin microbiome in free-ranging rhesus macaques
by: Christina E. Roche, et al.
Published: (2023-10-01)

Neuroinflammatory Profiling in SIV-Infected Chinese-Origin Rhesus Macaques on Antiretroviral Therapy
by: Antonio Solis-Leal, et al.
Published: (2022-01-01)

Integrative analysis associates monocytes with insufficient erythropoiesis during acute Plasmodium cynomolgi malaria in rhesus macaques
by: Yan Tang, et al.
Published: (2017-09-01)