Efficacy of intravenous dexmedetomidine versus intraperitoneal dexmedetomidine in laparoscopic cholecystectomy – A prospective randomized double-blinded study
Background: Dexmedetomidine now has become one of the frequently used drugs as part of a multimodal analgesic regimen to provide improved pain control at all perioperative stages for laparoscopic surgeries. Aims and Objectives: In this prospective, double-blind, randomized, and control trial, we...
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| Format: | Article |
| Language: | English |
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Manipal College of Medical Sciences, Pokhara
2022-08-01
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| Series: | Asian Journal of Medical Sciences |
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| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/42565 |
| _version_ | 1818472285759078400 |
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| author | Sumati Kandi Laxmi Kanta Panigraghy Harish chandra Dhamudia Pradipta Kumar Patel Panchanana Sethi |
| author_facet | Sumati Kandi Laxmi Kanta Panigraghy Harish chandra Dhamudia Pradipta Kumar Patel Panchanana Sethi |
| author_sort | Sumati Kandi |
| collection | DOAJ |
| description | Background: Dexmedetomidine now has become one of the frequently used drugs as part of a multimodal analgesic regimen to provide improved pain control at all perioperative stages for laparoscopic surgeries.
Aims and Objectives: In this prospective, double-blind, randomized, and control trial, we compared the postoperative analgesic efficacy of intravenous (IV) dexmedetomidine and intraperitoneal (IP) dexmedetomidine in laparoscopic cholecystectomy.
Materials and Methods: Sixty patients of the American Society of Anesthesiologists Grade I and II undergoing laparoscopic cholecystectomy were allocated into two groups. The patients in Group-IV had received 30 ml of 0.5 μg/kg Dexmedetomidine infusion intravenously plus 40 ml of Ropivacaine (30 mL of 0.5% Ropivacaine and 10 ml NS) intraperitoneally and in Group-IP received 30 ml NS intravenously and 40 ml of Ropivacaine plus Dexmedetomidine (30 mL of 0.5% Ropivacaine and 0.5 μg/kg Dexmedetomidine diluted in 10 ml NS) intraperitoneally after removal of the gallbladder. Patients were assessed during the first 24 h postoperatively for time to the first requirement of analgesia, total analgesic consumption, sedation, hemodynamics, side effects, and patient satisfaction.
Results: Time to first request of analgesia (min) was longer (216.46±42.19 vs. 108.03±48.77) and total analgesic consumption (mg) was lower (92.50±32.26 vs 115.0±38.056) in Group-IV than in Group-IP. A significant difference was observed in visual analogue score in Group-IV at 1 h, 2 h, 4 h postoperatively and in the patient satisfaction score (P=0.024) in comparison to Group-IP.
Conclusion: The postoperative analgesic effects and patient satisfaction, of low dose IV Dexmedetomidine plus IP instillation of Ropivacaine, are superior to low dose IP Dexmedetomidine added to Ropivacaine. |
| first_indexed | 2024-04-14T04:04:57Z |
| format | Article |
| id | doaj.art-80b42793e73a4582b13948b5d67727c6 |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-04-14T04:04:57Z |
| publishDate | 2022-08-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-80b42793e73a4582b13948b5d67727c62022-12-22T02:13:24ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762022-08-011381926https://doi.org/10.3126/ajms.v13i8.42565Efficacy of intravenous dexmedetomidine versus intraperitoneal dexmedetomidine in laparoscopic cholecystectomy – A prospective randomized double-blinded studySumati Kandi 0https://orcid.org/0000-0002-4963-0359Laxmi Kanta Panigraghy 1Harish chandra Dhamudia 2https://orcid.org/0000-0001-5239-8573Pradipta Kumar Patel 3Panchanana Sethi 4Assistant Professor, Department of Anaesthesiology, Veer Surendra Sai Institute of Medical Science and Research, Sambalpur, Odisha, India Assistant Professor, Department of Anaesthesiology, Veer Surendra Sai Institute of Medical Science and Research, Sambalpur, Odisha, IndiaAssistant Professor, Department of General Surgery, Veer Surendra Sai Institute of Medical Science and Research, Sambalpur, Odisha, India Associate Professor, Department of Anaesthesiology, Veer Surendra Sai Institute of Medical Science and Research, Sambalpur, Odisha, IndiaJunior Resident, Department of Anaesthesiology, Veer Surendra Sai Institute of Medical Science and Research, Sambalpur, Odisha, IndiaBackground: Dexmedetomidine now has become one of the frequently used drugs as part of a multimodal analgesic regimen to provide improved pain control at all perioperative stages for laparoscopic surgeries. Aims and Objectives: In this prospective, double-blind, randomized, and control trial, we compared the postoperative analgesic efficacy of intravenous (IV) dexmedetomidine and intraperitoneal (IP) dexmedetomidine in laparoscopic cholecystectomy. Materials and Methods: Sixty patients of the American Society of Anesthesiologists Grade I and II undergoing laparoscopic cholecystectomy were allocated into two groups. The patients in Group-IV had received 30 ml of 0.5 μg/kg Dexmedetomidine infusion intravenously plus 40 ml of Ropivacaine (30 mL of 0.5% Ropivacaine and 10 ml NS) intraperitoneally and in Group-IP received 30 ml NS intravenously and 40 ml of Ropivacaine plus Dexmedetomidine (30 mL of 0.5% Ropivacaine and 0.5 μg/kg Dexmedetomidine diluted in 10 ml NS) intraperitoneally after removal of the gallbladder. Patients were assessed during the first 24 h postoperatively for time to the first requirement of analgesia, total analgesic consumption, sedation, hemodynamics, side effects, and patient satisfaction. Results: Time to first request of analgesia (min) was longer (216.46±42.19 vs. 108.03±48.77) and total analgesic consumption (mg) was lower (92.50±32.26 vs 115.0±38.056) in Group-IV than in Group-IP. A significant difference was observed in visual analogue score in Group-IV at 1 h, 2 h, 4 h postoperatively and in the patient satisfaction score (P=0.024) in comparison to Group-IP. Conclusion: The postoperative analgesic effects and patient satisfaction, of low dose IV Dexmedetomidine plus IP instillation of Ropivacaine, are superior to low dose IP Dexmedetomidine added to Ropivacaine.https://www.nepjol.info/index.php/AJMS/article/view/42565dexmedetomidine; intraperitoneal instillation; postoperative pain; ropivacaine |
| spellingShingle | Sumati Kandi Laxmi Kanta Panigraghy Harish chandra Dhamudia Pradipta Kumar Patel Panchanana Sethi Efficacy of intravenous dexmedetomidine versus intraperitoneal dexmedetomidine in laparoscopic cholecystectomy – A prospective randomized double-blinded study Asian Journal of Medical Sciences dexmedetomidine; intraperitoneal instillation; postoperative pain; ropivacaine |
| title | Efficacy of intravenous dexmedetomidine versus intraperitoneal dexmedetomidine in laparoscopic cholecystectomy – A prospective randomized double-blinded study |
| title_full | Efficacy of intravenous dexmedetomidine versus intraperitoneal dexmedetomidine in laparoscopic cholecystectomy – A prospective randomized double-blinded study |
| title_fullStr | Efficacy of intravenous dexmedetomidine versus intraperitoneal dexmedetomidine in laparoscopic cholecystectomy – A prospective randomized double-blinded study |
| title_full_unstemmed | Efficacy of intravenous dexmedetomidine versus intraperitoneal dexmedetomidine in laparoscopic cholecystectomy – A prospective randomized double-blinded study |
| title_short | Efficacy of intravenous dexmedetomidine versus intraperitoneal dexmedetomidine in laparoscopic cholecystectomy – A prospective randomized double-blinded study |
| title_sort | efficacy of intravenous dexmedetomidine versus intraperitoneal dexmedetomidine in laparoscopic cholecystectomy a prospective randomized double blinded study |
| topic | dexmedetomidine; intraperitoneal instillation; postoperative pain; ropivacaine |
| url | https://www.nepjol.info/index.php/AJMS/article/view/42565 |
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