Venous Thromboembolism Prophylaxis in Intensive Care Units (Review)
Venous thromboembolism (VTE) is the third most frequent cause of death from cardiovascular diseases after myocardial infarction and stroke and the most preventable cause of mortality. VTE is common and potentially life-threatening in patients admitted to ICU, even in spite of preventive care.The pur...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2020-07-01
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| Series: | Общая реаниматология |
| Subjects: | |
| Online Access: | https://www.reanimatology.com/rmt/article/view/1924 |
| _version_ | 1797874207299731456 |
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| author | L. V. Popova T. B. Kondratieva M. Z. Kanevskaya T. L. Aleinikova E. S. Zykova А. V. Krivova A. M. Kuznetsov |
| author_facet | L. V. Popova T. B. Kondratieva M. Z. Kanevskaya T. L. Aleinikova E. S. Zykova А. V. Krivova A. M. Kuznetsov |
| author_sort | L. V. Popova |
| collection | DOAJ |
| description | Venous thromboembolism (VTE) is the third most frequent cause of death from cardiovascular diseases after myocardial infarction and stroke and the most preventable cause of mortality. VTE is common and potentially life-threatening in patients admitted to ICU, even in spite of preventive care.The purpose of the review is to justify the necessity of preventive care for venous thromboembolism in ICU patients.From over 300 initially selected sources of literature databases (Scopus, Web of science, RSCI, etc.), 99 sources were chosen including 69 that were published during the last five years (2015-2020). The exclusion criteria included data of low informative value or disproven data.The review discusses VTE relevance, risk factors for its development, selection and scope of preventive care depending on the risk of thrombosis and hemorrhage, patient management in different clinical settings (impaired renal function, thrombocytopenia, heparin-induced thrombocytopenia, liver dysfunction, indications for installation of vena cava filter).In the world literature, however, there is yet no consensus on the matter under discussion that would have been based on meta-analyses or large randomized studies. No agreement has been reached either in respect of use of mechanical and combined prophylaxis of venous thromboses/PATE, application of ultrasound to detect asymptomatic thromboses. There are no studies on efficacy and safety of pharmacological prophylaxis of VTE in patients with significant hepatic impairment.The review describes that all patients admitted in ICU feature a high risk of VTE development. The scope of preventive care depends not only on VTE risk but also on the risk of a hemorrhage. To prevent the latter, low-molecular weight heparins should be used. For most cases, the choice of heparine dose depends on renal function. When there is a high risk of hemorrhage, mechanical preventive aids are applied. |
| first_indexed | 2024-04-10T01:27:16Z |
| format | Article |
| id | doaj.art-80b77f88d8de4865ac5a5ccc1bcbc605 |
| institution | Directory Open Access Journal |
| issn | 1813-9779 2411-7110 |
| language | English |
| last_indexed | 2024-04-10T01:27:16Z |
| publishDate | 2020-07-01 |
| publisher | Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia |
| record_format | Article |
| series | Общая реаниматология |
| spelling | doaj.art-80b77f88d8de4865ac5a5ccc1bcbc6052023-03-13T09:32:56ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102020-07-0116310612510.15360/1813-9779-2020-3-106-1251747Venous Thromboembolism Prophylaxis in Intensive Care Units (Review)L. V. Popova0T. B. Kondratieva1M. Z. Kanevskaya2T. L. Aleinikova3E. S. Zykova4А. V. Krivova5A. M. Kuznetsov6Первый Московский государственный медицинский университет им. И. М. Сеченова Минздрава РоссииПервый Московский государственный медицинский университет им. И. М. Сеченова Минздрава РоссииПервый Московский государственный медицинский университет им. И. М. Сеченова Минздрава России; Городская клиническая больница им. А. К. Ерамишанцева Департамента здравоохранения г. МосквыПервый Московский государственный медицинский университет им. И. М. Сеченова Минздрава РоссииПервый Московский государственный медицинский университет им. И. М. Сеченова Минздрава РоссииПервый Московский государственный медицинский университет им. И. М. Сеченова Минздрава РоссииПервый Московский государственный медицинский университет им. И. М. Сеченова Минздрава РоссииVenous thromboembolism (VTE) is the third most frequent cause of death from cardiovascular diseases after myocardial infarction and stroke and the most preventable cause of mortality. VTE is common and potentially life-threatening in patients admitted to ICU, even in spite of preventive care.The purpose of the review is to justify the necessity of preventive care for venous thromboembolism in ICU patients.From over 300 initially selected sources of literature databases (Scopus, Web of science, RSCI, etc.), 99 sources were chosen including 69 that were published during the last five years (2015-2020). The exclusion criteria included data of low informative value or disproven data.The review discusses VTE relevance, risk factors for its development, selection and scope of preventive care depending on the risk of thrombosis and hemorrhage, patient management in different clinical settings (impaired renal function, thrombocytopenia, heparin-induced thrombocytopenia, liver dysfunction, indications for installation of vena cava filter).In the world literature, however, there is yet no consensus on the matter under discussion that would have been based on meta-analyses or large randomized studies. No agreement has been reached either in respect of use of mechanical and combined prophylaxis of venous thromboses/PATE, application of ultrasound to detect asymptomatic thromboses. There are no studies on efficacy and safety of pharmacological prophylaxis of VTE in patients with significant hepatic impairment.The review describes that all patients admitted in ICU feature a high risk of VTE development. The scope of preventive care depends not only on VTE risk but also on the risk of a hemorrhage. To prevent the latter, low-molecular weight heparins should be used. For most cases, the choice of heparine dose depends on renal function. When there is a high risk of hemorrhage, mechanical preventive aids are applied.https://www.reanimatology.com/rmt/article/view/1924венозный тромбоэмболизмпрофилактикаотделение интенсивной терапии |
| spellingShingle | L. V. Popova T. B. Kondratieva M. Z. Kanevskaya T. L. Aleinikova E. S. Zykova А. V. Krivova A. M. Kuznetsov Venous Thromboembolism Prophylaxis in Intensive Care Units (Review) Общая реаниматология венозный тромбоэмболизм профилактика отделение интенсивной терапии |
| title | Venous Thromboembolism Prophylaxis in Intensive Care Units (Review) |
| title_full | Venous Thromboembolism Prophylaxis in Intensive Care Units (Review) |
| title_fullStr | Venous Thromboembolism Prophylaxis in Intensive Care Units (Review) |
| title_full_unstemmed | Venous Thromboembolism Prophylaxis in Intensive Care Units (Review) |
| title_short | Venous Thromboembolism Prophylaxis in Intensive Care Units (Review) |
| title_sort | venous thromboembolism prophylaxis in intensive care units review |
| topic | венозный тромбоэмболизм профилактика отделение интенсивной терапии |
| url | https://www.reanimatology.com/rmt/article/view/1924 |
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