Graft-versus-host disease: Therapeutic prospects of improving the long-term post-transplant outcomes
Background: Graft-versus-host disease (GVHD) continues to emerge as the topmost causative factor of the morbidity and mortality rate post hematopoietic stem cell transplantation. The graft cells attack the recipient host tissues resulting in acute or chronic GVHD that affect organs, including the lu...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Transplantation Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2451959622000154 |
| _version_ | 1811197540393025536 |
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| author | Abdulaziz Umar Kurya Usama Aliyu Abdulrahman Ibrahim Tudu A.G Usman Mohd Yusuf Suneel Gupta Aleem Ali Mohd Gulfishan Santosh Kumar Singh Imran Hussain Mu'azu Gusau Abubakar |
| author_facet | Abdulaziz Umar Kurya Usama Aliyu Abdulrahman Ibrahim Tudu A.G Usman Mohd Yusuf Suneel Gupta Aleem Ali Mohd Gulfishan Santosh Kumar Singh Imran Hussain Mu'azu Gusau Abubakar |
| author_sort | Abdulaziz Umar Kurya |
| collection | DOAJ |
| description | Background: Graft-versus-host disease (GVHD) continues to emerge as the topmost causative factor of the morbidity and mortality rate post hematopoietic stem cell transplantation. The graft cells attack the recipient host tissues resulting in acute or chronic GVHD that affect organs, including the lung, liver, skin, and gastrointestinal tract. Certain factors are considered to play a crucial role in the progression of the disease, such as antibodies produced by B cells, reduction in regulatory T cells, and immune tolerance disruption to self-antigen. Main body: This review highlighted the pathophysiology of GVHD, clinical manifestation, stages of GVHD in different organs, and the significant role played by Janus Kinase/Signal Transducers and Activators of Transcription (JAK/STAT) in cytokine signalling, development, and function of several immune cells. Furthermore, we discussed the clinical efficacy of drugs, which comprises JAK inhibitors, monoclonal antibodies, and proteasome inhibitors that are widely used to treat GVHD. Conclusion: Considering the progress recorded in identifying the therapeutic regimens for GVHD, novel and effective therapeutic approaches are much needed to alleviate the complication that arises post hematopoietic stem cell transplantation and reduce the morbidity and mortality rate of the disease. |
| first_indexed | 2024-04-12T01:16:33Z |
| format | Article |
| id | doaj.art-80b8e703410a4635a3e38eaec2586b0f |
| institution | Directory Open Access Journal |
| issn | 2451-9596 |
| language | English |
| last_indexed | 2024-04-12T01:16:33Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Transplantation Reports |
| spelling | doaj.art-80b8e703410a4635a3e38eaec2586b0f2022-12-22T03:53:57ZengElsevierTransplantation Reports2451-95962022-12-0174100107Graft-versus-host disease: Therapeutic prospects of improving the long-term post-transplant outcomesAbdulaziz Umar Kurya0Usama Aliyu1Abdulrahman Ibrahim Tudu2A.G Usman3Mohd Yusuf4Suneel Gupta5Aleem Ali6Mohd Gulfishan7Santosh Kumar Singh8Imran Hussain9Mu'azu Gusau Abubakar10Department of Biotechnology, School of Life and Allied Health Sciences, Glocal University, Saharanpur, Uttar Pradesh 247121, India; Corresponding author.College of Health and Life Sciences, Hamad Bin Khalifa University, Education City, Doha, QatarFaculty of Chemistry, Warsaw University of Technology, Warsaw 00664, PolandOperational Research Centre in Healthcare, Near East University, Nicosia, Cyprus; Department of Analytical Chemistry, Faculty of Pharmacy, Near East University, Nicosia 99138, CyprusDepartment of Natural and Applied Science, School of Technology, The Glocal University, Saharanpur, Uttar Pradesh 247121, IndiaDepartment of Veterinary Medicine and Surgery, University of Missouri-Columbia, United StatesDepartment of Computer Science & Engineering, UIE, Chandigarh University, Mohali-Punjab, IndiaDepartment of Agriculture, Glocal University Saharanpur, Uttar Pradesh 247121, IndiaDepartment of Life Science, Sri Sathya Sai University for Human Excellence, Kalaburgi, Karnataka, IndiaDepartment of Biotechnology, School of Life and Allied Health Sciences, Glocal University, Saharanpur, Uttar Pradesh 247121, India; College of Health and Life Sciences, Hamad Bin Khalifa University, Education City, Doha, Qatar; Faculty of Chemistry, Warsaw University of Technology, Warsaw 00664, Poland; Operational Research Centre in Healthcare, Near East University, Nicosia, Cyprus; Department of Analytical Chemistry, Faculty of Pharmacy, Near East University, Nicosia 99138, Cyprus; Department of Natural and Applied Science, School of Technology, The Glocal University, Saharanpur, Uttar Pradesh 247121, India; Department of Veterinary Medicine and Surgery, University of Missouri-Columbia, United States; Department of Computer Science & Engineering, UIE, Chandigarh University, Mohali-Punjab, India; Department of Agriculture, Glocal University Saharanpur, Uttar Pradesh 247121, India; Department of Life Science, Sri Sathya Sai University for Human Excellence, Kalaburgi, Karnataka, India; Department of Biochemistry, Usmanu Danfodiyo University Sokoto 2346, Nigeria; School of Bioengineering and Biosciences, Department of Biochemistry, Lovely Professional University, Phagwara, Punjab-144001, IndiaDepartment of Biochemistry, Usmanu Danfodiyo University Sokoto 2346, NigeriaBackground: Graft-versus-host disease (GVHD) continues to emerge as the topmost causative factor of the morbidity and mortality rate post hematopoietic stem cell transplantation. The graft cells attack the recipient host tissues resulting in acute or chronic GVHD that affect organs, including the lung, liver, skin, and gastrointestinal tract. Certain factors are considered to play a crucial role in the progression of the disease, such as antibodies produced by B cells, reduction in regulatory T cells, and immune tolerance disruption to self-antigen. Main body: This review highlighted the pathophysiology of GVHD, clinical manifestation, stages of GVHD in different organs, and the significant role played by Janus Kinase/Signal Transducers and Activators of Transcription (JAK/STAT) in cytokine signalling, development, and function of several immune cells. Furthermore, we discussed the clinical efficacy of drugs, which comprises JAK inhibitors, monoclonal antibodies, and proteasome inhibitors that are widely used to treat GVHD. Conclusion: Considering the progress recorded in identifying the therapeutic regimens for GVHD, novel and effective therapeutic approaches are much needed to alleviate the complication that arises post hematopoietic stem cell transplantation and reduce the morbidity and mortality rate of the disease.http://www.sciencedirect.com/science/article/pii/S2451959622000154Graft-versus-host diseaseHematopoietic stem cell transplantationAcuteChronicInhibitors |
| spellingShingle | Abdulaziz Umar Kurya Usama Aliyu Abdulrahman Ibrahim Tudu A.G Usman Mohd Yusuf Suneel Gupta Aleem Ali Mohd Gulfishan Santosh Kumar Singh Imran Hussain Mu'azu Gusau Abubakar Graft-versus-host disease: Therapeutic prospects of improving the long-term post-transplant outcomes Transplantation Reports Graft-versus-host disease Hematopoietic stem cell transplantation Acute Chronic Inhibitors |
| title | Graft-versus-host disease: Therapeutic prospects of improving the long-term post-transplant outcomes |
| title_full | Graft-versus-host disease: Therapeutic prospects of improving the long-term post-transplant outcomes |
| title_fullStr | Graft-versus-host disease: Therapeutic prospects of improving the long-term post-transplant outcomes |
| title_full_unstemmed | Graft-versus-host disease: Therapeutic prospects of improving the long-term post-transplant outcomes |
| title_short | Graft-versus-host disease: Therapeutic prospects of improving the long-term post-transplant outcomes |
| title_sort | graft versus host disease therapeutic prospects of improving the long term post transplant outcomes |
| topic | Graft-versus-host disease Hematopoietic stem cell transplantation Acute Chronic Inhibitors |
| url | http://www.sciencedirect.com/science/article/pii/S2451959622000154 |
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