The Predictive Role of Neurobiochemical Markers in Multiple Sclerosis
Introduction:Multiple sclerosis (MS) is the most common, chronic, inflammatory, demyelinating disease of the central nervous system. We aimed to evaluate the levels of some neurobiochemical markers in order to evaluate their predictive role in MS.Methods:Fifty-one patients with a diagnosis of MS and...
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Galenos Yayinevi
2020-01-01
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| Series: | İstanbul Medical Journal |
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http://imj.galenos.com.tr/archives/archive-detail/article-preview/the-predictive-role-of-neurobiochemical-markers-in/34659
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| author | Esra Fırat Oğuz Semra Mungan Fatma Meriç Yılmaz Müjgan Ercan Sema Uysal |
| author_facet | Esra Fırat Oğuz Semra Mungan Fatma Meriç Yılmaz Müjgan Ercan Sema Uysal |
| author_sort | Esra Fırat Oğuz |
| collection | DOAJ |
| description | Introduction:Multiple sclerosis (MS) is the most common, chronic, inflammatory, demyelinating disease of the central nervous system. We aimed to evaluate the levels of some neurobiochemical markers in order to evaluate their predictive role in MS.Methods:Fifty-one patients with a diagnosis of MS and 37 healthy subjects were included in the study. The patients with MS were diagnosed by a skilled neurologist based on the medical history and physical examination according to revised McDonald criteria. Neuron-specific enolase (NSE) and S100B levels were measured by electrochemiluminescence immunoassay. Glial fibrillary acidic protein (GFAP) and myelin basic protein (MBP) were measured by quantitive sandwich enzyme immunoassay technique with a commercially available ELISA kit.Results:There was a significant difference in NSE levels between the patient and the control groups. No significant difference was determined between the patient and the control groups in terms of S100B, MBP, and GFAP levels. S100B levels were positively correlated with Expanded Disability Status scale scores.Conclusion:Our findings indicated that NSE levels are significantly lower in MS patients. However, NSE levels should not be used alone at discriminating the disease. Multifactorial evaluation should be done during the diagnosis and follow-up of MS. |
| first_indexed | 2024-04-10T14:40:29Z |
| format | Article |
| id | doaj.art-80ba514927cb45f7bd6c78e904466756 |
| institution | Directory Open Access Journal |
| issn | 2619-9793 2148-094X |
| language | English |
| last_indexed | 2024-04-10T14:40:29Z |
| publishDate | 2020-01-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | İstanbul Medical Journal |
| spelling | doaj.art-80ba514927cb45f7bd6c78e9044667562023-02-15T16:08:14ZengGalenos Yayineviİstanbul Medical Journal2619-97932148-094X2020-01-01211232710.4274/imj.galenos.2019.7500213049054The Predictive Role of Neurobiochemical Markers in Multiple SclerosisEsra Fırat Oğuz0Semra Mungan1Fatma Meriç Yılmaz2Müjgan Ercan3Sema Uysal4 University of Health Sciences, Ankara Numune Training and Research Hospital, Clinic of Biochemistry, Ankara, Turkey University of Health Sciences, Ankara Numune Training and Research Hospital, Clinic of Neurology, Ankara, Turkey Ankara Yıldırım Beyazıt University Faculty of Medicine, Department of Biochemistry, Ankara, Turkey Yozgat Bozok University Faculty of Medicine, Department of Biochemistry, Yozgat, Turkey Çanakkale Onsekiz Mart University Faculty of Medicine, Department of Biochemistry, Çanakkale, Turkey Introduction:Multiple sclerosis (MS) is the most common, chronic, inflammatory, demyelinating disease of the central nervous system. We aimed to evaluate the levels of some neurobiochemical markers in order to evaluate their predictive role in MS.Methods:Fifty-one patients with a diagnosis of MS and 37 healthy subjects were included in the study. The patients with MS were diagnosed by a skilled neurologist based on the medical history and physical examination according to revised McDonald criteria. Neuron-specific enolase (NSE) and S100B levels were measured by electrochemiluminescence immunoassay. Glial fibrillary acidic protein (GFAP) and myelin basic protein (MBP) were measured by quantitive sandwich enzyme immunoassay technique with a commercially available ELISA kit.Results:There was a significant difference in NSE levels between the patient and the control groups. No significant difference was determined between the patient and the control groups in terms of S100B, MBP, and GFAP levels. S100B levels were positively correlated with Expanded Disability Status scale scores.Conclusion:Our findings indicated that NSE levels are significantly lower in MS patients. However, NSE levels should not be used alone at discriminating the disease. Multifactorial evaluation should be done during the diagnosis and follow-up of MS. http://imj.galenos.com.tr/archives/archive-detail/article-preview/the-predictive-role-of-neurobiochemical-markers-in/34659 multiple sclerosisgfapmbpnses100b |
| spellingShingle | Esra Fırat Oğuz Semra Mungan Fatma Meriç Yılmaz Müjgan Ercan Sema Uysal The Predictive Role of Neurobiochemical Markers in Multiple Sclerosis İstanbul Medical Journal multiple sclerosis gfap mbp nse s100b |
| title | The Predictive Role of Neurobiochemical Markers in Multiple Sclerosis |
| title_full | The Predictive Role of Neurobiochemical Markers in Multiple Sclerosis |
| title_fullStr | The Predictive Role of Neurobiochemical Markers in Multiple Sclerosis |
| title_full_unstemmed | The Predictive Role of Neurobiochemical Markers in Multiple Sclerosis |
| title_short | The Predictive Role of Neurobiochemical Markers in Multiple Sclerosis |
| title_sort | predictive role of neurobiochemical markers in multiple sclerosis |
| topic | multiple sclerosis gfap mbp nse s100b |
| url |
http://imj.galenos.com.tr/archives/archive-detail/article-preview/the-predictive-role-of-neurobiochemical-markers-in/34659
|
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