Formulation of Sustained Release Hydrophilic Matrix Tablets of Tolcapone with the Application of Sedem Diagram: Influence of Tolcapone’s Particle Size on Sustained Release

Formulation of Sustained Release Hydrophilic Matrix Tablets of Tolcapone with the Application of Sedem Diagram: Influence of Tolcapone’s Particle Size on Sustained Release

Hydrophilic matrix tablets are a type of sustained release dosage form characterized by distributing a drug in a matrix that is usually polymeric. Tolcapone is a drug that inhibits the enzyme catechol-<i>O</i>-methyl transferase. In recent years, it has been shown that tolcapone is a pot...

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Bibliographic Details
Main Authors: Anna Nardi-Ricart, Isaac Nofrerias-Roig, Marc Suñé-Pou, Pilar Pérez-Lozano, Montse Miñarro-Carmona, Encarna García-Montoya, Josep R. Ticó-Grau, Raul Insa Boronat, Josep M. Suñé-Negre
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Pharmaceutics
Subjects:
hydrophilic matrix tablets
tolcapone
sustained release
particle size
SeDeM diagram
direct compression
Online Access:https://www.mdpi.com/1999-4923/12/7/674

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