Comparison of the Protective Effects of Bee Venom Extracts with Varying PLA<sub>2</sub> Compositions in a Mouse Model of Parkinson’s Disease
Bee venom contains a number of pharmacologically active components, including enzymes and polypeptides such as phospholipase A<sub>2</sub> (PLA<sub>2</sub>) and melittin, which have been shown to exhibit therapeutic benefits, mainly via attenuation of inflammation, neurotoxic...
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MDPI AG
2019-06-01
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| Series: | Toxins |
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| Online Access: | https://www.mdpi.com/2072-6651/11/6/358 |
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| author | Kyung Hwa Kim Minhwan Kim Jaehwan Lee Hat Nim Jeon Se Hyun Kim Hyunsu Bae |
| author_facet | Kyung Hwa Kim Minhwan Kim Jaehwan Lee Hat Nim Jeon Se Hyun Kim Hyunsu Bae |
| author_sort | Kyung Hwa Kim |
| collection | DOAJ |
| description | Bee venom contains a number of pharmacologically active components, including enzymes and polypeptides such as phospholipase A<sub>2</sub> (PLA<sub>2</sub>) and melittin, which have been shown to exhibit therapeutic benefits, mainly via attenuation of inflammation, neurotoxicity, and nociception. The individual components of bee venom may manifest distinct biological actions and therapeutic potential. In this study, the potential mechanisms of action of PLA<sub>2</sub> and melittin, among different compounds purified from honey bee venom, were evaluated against Parkinson’s disease (PD). Notably, bee venom PLA<sub>2</sub> (bvPLA<sub>2</sub>), but not melittin, exhibited neuroprotective activity against PD in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD. MPTP-induced behavioral deficits were also abolished after bvPLA<sub>2</sub> treatment, depending on the PLA<sub>2</sub> content. Further, bvPLA<sub>2</sub> administration activated regulatory T cells (Tregs) while inhibiting inflammatory T helper (Th) 1 and Th17 cells in the MPTP mouse model of PD. These results indicate that bvPLA<sub>2</sub>, but not melittin, protected against MPTP and alleviated inflammation in PD. Thus, bvPLA<sub>2</sub> is a promising and effective therapeutic agent in Parkinson’s disease. |
| first_indexed | 2024-04-13T06:51:21Z |
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| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-04-13T06:51:21Z |
| publishDate | 2019-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-80bb097ff2514723b80e3a7abaa89a8c2022-12-22T02:57:23ZengMDPI AGToxins2072-66512019-06-0111635810.3390/toxins11060358toxins11060358Comparison of the Protective Effects of Bee Venom Extracts with Varying PLA<sub>2</sub> Compositions in a Mouse Model of Parkinson’s DiseaseKyung Hwa Kim0Minhwan Kim1Jaehwan Lee2Hat Nim Jeon3Se Hyun Kim4Hyunsu Bae5Department of Physiology, College of Korean Medicine, Kyung Hee University, Seoul 02447, KoreaDepartment of Physiology, College of Korean Medicine, Kyung Hee University, Seoul 02447, KoreaDepartment of Physiology, College of Korean Medicine, Kyung Hee University, Seoul 02447, KoreaDepartment of Physiology, College of Korean Medicine, Kyung Hee University, Seoul 02447, KoreaInist ST Co. Ltd., 159 Sagimakgol-ro, Jungwon-gu, Seongnam-si, Gyeonggi-do 13202, KoreaDepartment of Physiology, College of Korean Medicine, Kyung Hee University, Seoul 02447, KoreaBee venom contains a number of pharmacologically active components, including enzymes and polypeptides such as phospholipase A<sub>2</sub> (PLA<sub>2</sub>) and melittin, which have been shown to exhibit therapeutic benefits, mainly via attenuation of inflammation, neurotoxicity, and nociception. The individual components of bee venom may manifest distinct biological actions and therapeutic potential. In this study, the potential mechanisms of action of PLA<sub>2</sub> and melittin, among different compounds purified from honey bee venom, were evaluated against Parkinson’s disease (PD). Notably, bee venom PLA<sub>2</sub> (bvPLA<sub>2</sub>), but not melittin, exhibited neuroprotective activity against PD in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD. MPTP-induced behavioral deficits were also abolished after bvPLA<sub>2</sub> treatment, depending on the PLA<sub>2</sub> content. Further, bvPLA<sub>2</sub> administration activated regulatory T cells (Tregs) while inhibiting inflammatory T helper (Th) 1 and Th17 cells in the MPTP mouse model of PD. These results indicate that bvPLA<sub>2</sub>, but not melittin, protected against MPTP and alleviated inflammation in PD. Thus, bvPLA<sub>2</sub> is a promising and effective therapeutic agent in Parkinson’s disease.https://www.mdpi.com/2072-6651/11/6/358bee venomphospholipase A<sub>2</sub>melittinParkinson’s diseaseneuroprotectioninflammationregulatory T cells |
| spellingShingle | Kyung Hwa Kim Minhwan Kim Jaehwan Lee Hat Nim Jeon Se Hyun Kim Hyunsu Bae Comparison of the Protective Effects of Bee Venom Extracts with Varying PLA<sub>2</sub> Compositions in a Mouse Model of Parkinson’s Disease Toxins bee venom phospholipase A<sub>2</sub> melittin Parkinson’s disease neuroprotection inflammation regulatory T cells |
| title | Comparison of the Protective Effects of Bee Venom Extracts with Varying PLA<sub>2</sub> Compositions in a Mouse Model of Parkinson’s Disease |
| title_full | Comparison of the Protective Effects of Bee Venom Extracts with Varying PLA<sub>2</sub> Compositions in a Mouse Model of Parkinson’s Disease |
| title_fullStr | Comparison of the Protective Effects of Bee Venom Extracts with Varying PLA<sub>2</sub> Compositions in a Mouse Model of Parkinson’s Disease |
| title_full_unstemmed | Comparison of the Protective Effects of Bee Venom Extracts with Varying PLA<sub>2</sub> Compositions in a Mouse Model of Parkinson’s Disease |
| title_short | Comparison of the Protective Effects of Bee Venom Extracts with Varying PLA<sub>2</sub> Compositions in a Mouse Model of Parkinson’s Disease |
| title_sort | comparison of the protective effects of bee venom extracts with varying pla sub 2 sub compositions in a mouse model of parkinson s disease |
| topic | bee venom phospholipase A<sub>2</sub> melittin Parkinson’s disease neuroprotection inflammation regulatory T cells |
| url | https://www.mdpi.com/2072-6651/11/6/358 |
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