Rapid Assessment of Di(2-ethylhexyl) Phthalate Migration from Consumer PVC Products
Poly(vinyl chloride) (PVC) is widely used to produce various consumer goods, including food packaging, toys for children, building materials, and cosmetic products. However, despite their widespread use, phthalate plasticizers have been identified as endocrine disruptors, which cause adverse health...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Toxics |
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| Online Access: | https://www.mdpi.com/2305-6304/12/1/7 |
| _version_ | 1797342505168011264 |
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| author | Jiwon An Hyun-Ho Roh Haeyoon Jeong Kuen-Yong Lee Taiyoun Rhim |
| author_facet | Jiwon An Hyun-Ho Roh Haeyoon Jeong Kuen-Yong Lee Taiyoun Rhim |
| author_sort | Jiwon An |
| collection | DOAJ |
| description | Poly(vinyl chloride) (PVC) is widely used to produce various consumer goods, including food packaging, toys for children, building materials, and cosmetic products. However, despite their widespread use, phthalate plasticizers have been identified as endocrine disruptors, which cause adverse health effects, thus leading to increasing concerns regarding their migration from PVC products to the environment. This study proposed a method for rapidly measuring the migration of phthalates, particularly di(2-ethylhexyl) phthalate (DEHP), from PVC products to commonly encountered liquids. The release of DEHP under various conditions, including exposure to aqueous and organic solvents, different temperatures, and household microwaves, was investigated. The amount of DEHP released from both laboratory-produced PVC films and commercially available PVC products was measured to elucidate the potential risks associated with its real-world applications. Furthermore, tests were performed to evaluate cytotoxicity using estrogen-dependent and -independent cancer cell lines. The results revealed a dose-dependent impact on estrogen-dependent cells, thus emphasizing the potential health implications of phthalate release. This comprehensive study provides valuable insights into the migration patterns of DEHP from PVC products and forms a basis for further research on the safety of PVC and plasticizers. |
| first_indexed | 2024-03-08T10:34:30Z |
| format | Article |
| id | doaj.art-80bd74fc5cba4c6e9ca1875462abc26e |
| institution | Directory Open Access Journal |
| issn | 2305-6304 |
| language | English |
| last_indexed | 2024-03-08T10:34:30Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxics |
| spelling | doaj.art-80bd74fc5cba4c6e9ca1875462abc26e2024-01-26T18:40:48ZengMDPI AGToxics2305-63042023-12-01121710.3390/toxics12010007Rapid Assessment of Di(2-ethylhexyl) Phthalate Migration from Consumer PVC ProductsJiwon An0Hyun-Ho Roh1Haeyoon Jeong2Kuen-Yong Lee3Taiyoun Rhim4Department of Bioengineering, College of Engineering, Hanyang University, Seoul 04763, Republic of KoreaDepartment of Bioengineering, College of Engineering, Hanyang University, Seoul 04763, Republic of KoreaDepartment of Bioengineering, College of Engineering, Hanyang University, Seoul 04763, Republic of KoreaDepartment of Bioengineering, College of Engineering, Hanyang University, Seoul 04763, Republic of KoreaDepartment of Bioengineering, College of Engineering, Hanyang University, Seoul 04763, Republic of KoreaPoly(vinyl chloride) (PVC) is widely used to produce various consumer goods, including food packaging, toys for children, building materials, and cosmetic products. However, despite their widespread use, phthalate plasticizers have been identified as endocrine disruptors, which cause adverse health effects, thus leading to increasing concerns regarding their migration from PVC products to the environment. This study proposed a method for rapidly measuring the migration of phthalates, particularly di(2-ethylhexyl) phthalate (DEHP), from PVC products to commonly encountered liquids. The release of DEHP under various conditions, including exposure to aqueous and organic solvents, different temperatures, and household microwaves, was investigated. The amount of DEHP released from both laboratory-produced PVC films and commercially available PVC products was measured to elucidate the potential risks associated with its real-world applications. Furthermore, tests were performed to evaluate cytotoxicity using estrogen-dependent and -independent cancer cell lines. The results revealed a dose-dependent impact on estrogen-dependent cells, thus emphasizing the potential health implications of phthalate release. This comprehensive study provides valuable insights into the migration patterns of DEHP from PVC products and forms a basis for further research on the safety of PVC and plasticizers.https://www.mdpi.com/2305-6304/12/1/7phthalate esterpoly(vinyl chloride)consumer productpackaging materialelution |
| spellingShingle | Jiwon An Hyun-Ho Roh Haeyoon Jeong Kuen-Yong Lee Taiyoun Rhim Rapid Assessment of Di(2-ethylhexyl) Phthalate Migration from Consumer PVC Products Toxics phthalate ester poly(vinyl chloride) consumer product packaging material elution |
| title | Rapid Assessment of Di(2-ethylhexyl) Phthalate Migration from Consumer PVC Products |
| title_full | Rapid Assessment of Di(2-ethylhexyl) Phthalate Migration from Consumer PVC Products |
| title_fullStr | Rapid Assessment of Di(2-ethylhexyl) Phthalate Migration from Consumer PVC Products |
| title_full_unstemmed | Rapid Assessment of Di(2-ethylhexyl) Phthalate Migration from Consumer PVC Products |
| title_short | Rapid Assessment of Di(2-ethylhexyl) Phthalate Migration from Consumer PVC Products |
| title_sort | rapid assessment of di 2 ethylhexyl phthalate migration from consumer pvc products |
| topic | phthalate ester poly(vinyl chloride) consumer product packaging material elution |
| url | https://www.mdpi.com/2305-6304/12/1/7 |
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