Subclinical epileptiform activity and sleep disturbances in Alzheimer's disease
ABSTRACT Introduction Subclinical epileptiform activity (SEA) and sleep disturbances are frequent in Alzheimer's disease (AD). Both have an important relation to cognition and potential therapeutic implications. We aimed to study a possible relationship between SEA and sleep disturbances in AD....
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-12-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.3306 |
| _version_ | 1797336370732072960 |
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| author | Astrid Devulder Jaiver Macea Alexandros Kalkanis François‐Laurent De Winter Mathieu Vandenbulcke Rik Vandenberghe Dries Testelmans Maarten J. A. Van Den Bossche Wim Van Paesschen |
| author_facet | Astrid Devulder Jaiver Macea Alexandros Kalkanis François‐Laurent De Winter Mathieu Vandenbulcke Rik Vandenberghe Dries Testelmans Maarten J. A. Van Den Bossche Wim Van Paesschen |
| author_sort | Astrid Devulder |
| collection | DOAJ |
| description | ABSTRACT Introduction Subclinical epileptiform activity (SEA) and sleep disturbances are frequent in Alzheimer's disease (AD). Both have an important relation to cognition and potential therapeutic implications. We aimed to study a possible relationship between SEA and sleep disturbances in AD. Methods In this cross‐sectional study, we performed a 24‐h ambulatory EEG and polysomnography in 48 AD patients without diagnosis of epilepsy and 34 control subjects. Results SEA, mainly detected in frontotemporal brain regions during N2 with a median of three spikes/night [IQR1–17], was three times more prevalent in AD. AD patients had lower sleep efficacy, longer wake after sleep onset, more awakenings, more N1%, less REM sleep and a higher apnea‐hypopnea index (AHI) and oxygen desaturation index (ODI). Sleep was not different between AD subgroup with SEA (AD‐Epi+) and without SEA (AD‐Epi–); however, compared to controls, REM% was decreased and AHI and ODI were increased in the AD‐Epi+ subgroup. Discussion Decreased REM sleep and more severe sleep‐disordered breathing might be related to SEA in AD. These results could have diagnostic and therapeutic implications and warrant further study at the intersection between sleep and epileptiform activity in AD. |
| first_indexed | 2024-03-08T08:53:27Z |
| format | Article |
| id | doaj.art-80bdb158205347f89308d8252bd0b9a4 |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-03-08T08:53:27Z |
| publishDate | 2023-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-80bdb158205347f89308d8252bd0b9a42024-02-01T07:45:36ZengWileyBrain and Behavior2162-32792023-12-011312n/an/a10.1002/brb3.3306Subclinical epileptiform activity and sleep disturbances in Alzheimer's diseaseAstrid Devulder0Jaiver Macea1Alexandros Kalkanis2François‐Laurent De Winter3Mathieu Vandenbulcke4Rik Vandenberghe5Dries Testelmans6Maarten J. A. Van Den Bossche7Wim Van Paesschen8Laboratory for Epilepsy Research, KU Leuven and Department of Neurology University Hospitals Leuven Leuven BelgiumLaboratory for Epilepsy Research, KU Leuven and Department of Neurology University Hospitals Leuven Leuven BelgiumLaboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), KU Leuven and Department of Pulmonary Diseases University Hospitals Leuven Leuven BelgiumDivision of Neuropsychiatry, Department of Neurosciences, Leuven Brain Institute, KU Leuven and Department of Geriatric Psychiatry University Psychiatric Center (UPC) KU Leuven Leuven BelgiumDivision of Neuropsychiatry, Department of Neurosciences, Leuven Brain Institute, KU Leuven and Department of Geriatric Psychiatry University Psychiatric Center (UPC) KU Leuven Leuven BelgiumLaboratory for Cognitive Neurology, KU Leuven and Department of Neurology University Hospitals Leuven Leuven BelgiumLaboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), KU Leuven and Department of Pulmonary Diseases University Hospitals Leuven Leuven BelgiumDivision of Neuropsychiatry, Department of Neurosciences, Leuven Brain Institute, KU Leuven and Department of Geriatric Psychiatry University Psychiatric Center (UPC) KU Leuven Leuven BelgiumLaboratory for Epilepsy Research, KU Leuven and Department of Neurology University Hospitals Leuven Leuven BelgiumABSTRACT Introduction Subclinical epileptiform activity (SEA) and sleep disturbances are frequent in Alzheimer's disease (AD). Both have an important relation to cognition and potential therapeutic implications. We aimed to study a possible relationship between SEA and sleep disturbances in AD. Methods In this cross‐sectional study, we performed a 24‐h ambulatory EEG and polysomnography in 48 AD patients without diagnosis of epilepsy and 34 control subjects. Results SEA, mainly detected in frontotemporal brain regions during N2 with a median of three spikes/night [IQR1–17], was three times more prevalent in AD. AD patients had lower sleep efficacy, longer wake after sleep onset, more awakenings, more N1%, less REM sleep and a higher apnea‐hypopnea index (AHI) and oxygen desaturation index (ODI). Sleep was not different between AD subgroup with SEA (AD‐Epi+) and without SEA (AD‐Epi–); however, compared to controls, REM% was decreased and AHI and ODI were increased in the AD‐Epi+ subgroup. Discussion Decreased REM sleep and more severe sleep‐disordered breathing might be related to SEA in AD. These results could have diagnostic and therapeutic implications and warrant further study at the intersection between sleep and epileptiform activity in AD.https://doi.org/10.1002/brb3.3306Alzheimer's diseaseepileptiform activityobstructive sleep apneaREM sleepsleep |
| spellingShingle | Astrid Devulder Jaiver Macea Alexandros Kalkanis François‐Laurent De Winter Mathieu Vandenbulcke Rik Vandenberghe Dries Testelmans Maarten J. A. Van Den Bossche Wim Van Paesschen Subclinical epileptiform activity and sleep disturbances in Alzheimer's disease Brain and Behavior Alzheimer's disease epileptiform activity obstructive sleep apnea REM sleep sleep |
| title | Subclinical epileptiform activity and sleep disturbances in Alzheimer's disease |
| title_full | Subclinical epileptiform activity and sleep disturbances in Alzheimer's disease |
| title_fullStr | Subclinical epileptiform activity and sleep disturbances in Alzheimer's disease |
| title_full_unstemmed | Subclinical epileptiform activity and sleep disturbances in Alzheimer's disease |
| title_short | Subclinical epileptiform activity and sleep disturbances in Alzheimer's disease |
| title_sort | subclinical epileptiform activity and sleep disturbances in alzheimer s disease |
| topic | Alzheimer's disease epileptiform activity obstructive sleep apnea REM sleep sleep |
| url | https://doi.org/10.1002/brb3.3306 |
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