Effects of low-dose furosemide combined with aminophylline on the renal function in septic shock patients
AbstractBackground To investigate the effects of low-dose furosemide and aminophylline on the renal function in patients with septic shock.Methods and Results A total of 109 eligible septic shock patients in the intensive care unit were randomly divided into a control group (n = 55) and an intervent...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Renal Failure |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2185084 |
| _version_ | 1797658516696072192 |
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| author | Zhenhua Mai Yaying Tan Yang Zhu Zilong Yang Hongpeng Chen Shuting Cai Wangwang Hu Xiaoyan Wang Fenghua Ding Liehua Deng |
| author_facet | Zhenhua Mai Yaying Tan Yang Zhu Zilong Yang Hongpeng Chen Shuting Cai Wangwang Hu Xiaoyan Wang Fenghua Ding Liehua Deng |
| author_sort | Zhenhua Mai |
| collection | DOAJ |
| description | AbstractBackground To investigate the effects of low-dose furosemide and aminophylline on the renal function in patients with septic shock.Methods and Results A total of 109 eligible septic shock patients in the intensive care unit were randomly divided into a control group (n = 55) and an intervention group (n = 54). The control group received normal saline, and the intervention group received low-dose furosemide (0.048 mg/kg.h−1) with aminophylline (0.3 mg/kg.h−1). The primary outcomes included the levels of serum creatinine (Scr), creatinine clearance rate (Ccr), blood urea nitrogen (BUN), glomerular filtration rate (GFR), and urine output on admission and on days 3, 7 and 14. The secondary outcomes were the sequential organ failure assessment (SOFA) scores, continuous renal replacement therapy (CRRT) time and intensive care unit (ICU) mortality, hospital mortality and 28-day mortality. There were no significant differences in the levels of Scr, Ccr, BUN, or GFR between the two groups, while the urine output was higher in the intervention group on days 3, 7, and 14. Compared with the control group, the SOFA scores, ICU mortality, hospital mortality and 28-day mortality were significantly lower in the intervention group on days 3, 7, and 14, the CRRT time was shorter, and the cumulative fluid balance was lower on days 3 and 7 in the intervention group.Conclusions Although low-dose furosemide and aminophylline have fewer protective effects on the renal function in septic shock patients, they could reduce the CRRT time and improve the prognosis. |
| first_indexed | 2024-03-11T18:00:08Z |
| format | Article |
| id | doaj.art-80be08030e9d4665ae27e380961ee7d5 |
| institution | Directory Open Access Journal |
| issn | 0886-022X 1525-6049 |
| language | English |
| last_indexed | 2024-03-11T18:00:08Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj.art-80be08030e9d4665ae27e380961ee7d52023-10-17T09:23:23ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492023-12-0145110.1080/0886022X.2023.2185084Effects of low-dose furosemide combined with aminophylline on the renal function in septic shock patientsZhenhua Mai0Yaying Tan1Yang Zhu2Zilong Yang3Hongpeng Chen4Shuting Cai5Wangwang Hu6Xiaoyan Wang7Fenghua Ding8Liehua Deng9Department of Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, ChinaDepartment of Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, ChinaDepartment of Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, ChinaDepartment of Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, ChinaDepartment of Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, ChinaDepartment of Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, ChinaDepartment of Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, ChinaDepartment of Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, ChinaDepartment of Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, ChinaDepartment of Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, ChinaAbstractBackground To investigate the effects of low-dose furosemide and aminophylline on the renal function in patients with septic shock.Methods and Results A total of 109 eligible septic shock patients in the intensive care unit were randomly divided into a control group (n = 55) and an intervention group (n = 54). The control group received normal saline, and the intervention group received low-dose furosemide (0.048 mg/kg.h−1) with aminophylline (0.3 mg/kg.h−1). The primary outcomes included the levels of serum creatinine (Scr), creatinine clearance rate (Ccr), blood urea nitrogen (BUN), glomerular filtration rate (GFR), and urine output on admission and on days 3, 7 and 14. The secondary outcomes were the sequential organ failure assessment (SOFA) scores, continuous renal replacement therapy (CRRT) time and intensive care unit (ICU) mortality, hospital mortality and 28-day mortality. There were no significant differences in the levels of Scr, Ccr, BUN, or GFR between the two groups, while the urine output was higher in the intervention group on days 3, 7, and 14. Compared with the control group, the SOFA scores, ICU mortality, hospital mortality and 28-day mortality were significantly lower in the intervention group on days 3, 7, and 14, the CRRT time was shorter, and the cumulative fluid balance was lower on days 3 and 7 in the intervention group.Conclusions Although low-dose furosemide and aminophylline have fewer protective effects on the renal function in septic shock patients, they could reduce the CRRT time and improve the prognosis.https://www.tandfonline.com/doi/10.1080/0886022X.2023.2185084Septic shockaminophyllinefurosemideacute kidney injurymortality |
| spellingShingle | Zhenhua Mai Yaying Tan Yang Zhu Zilong Yang Hongpeng Chen Shuting Cai Wangwang Hu Xiaoyan Wang Fenghua Ding Liehua Deng Effects of low-dose furosemide combined with aminophylline on the renal function in septic shock patients Renal Failure Septic shock aminophylline furosemide acute kidney injury mortality |
| title | Effects of low-dose furosemide combined with aminophylline on the renal function in septic shock patients |
| title_full | Effects of low-dose furosemide combined with aminophylline on the renal function in septic shock patients |
| title_fullStr | Effects of low-dose furosemide combined with aminophylline on the renal function in septic shock patients |
| title_full_unstemmed | Effects of low-dose furosemide combined with aminophylline on the renal function in septic shock patients |
| title_short | Effects of low-dose furosemide combined with aminophylline on the renal function in septic shock patients |
| title_sort | effects of low dose furosemide combined with aminophylline on the renal function in septic shock patients |
| topic | Septic shock aminophylline furosemide acute kidney injury mortality |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2185084 |
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