Tailoring Mesoporous Silica-Coated Silver Nanoparticles and Polyurethane-Doped Films for Enhanced Antimicrobial Applications
The global increase in multidrug-resistant bacteria poses a challenge to public health and requires the development of new antibacterial materials. In this study, we examined the bactericidal properties of mesoporous silica-coated silver nanoparticles, varying the core sizes (ca. 28 nm and 51 nm). W...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/14/5/462 |
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| author | Silvia Nuti Adrián Fernández-Lodeiro Joana Galhano Elisabete Oliveira Maria Paula Duarte José Luis Capelo-Martínez Carlos Lodeiro Javier Fernández-Lodeiro |
| author_facet | Silvia Nuti Adrián Fernández-Lodeiro Joana Galhano Elisabete Oliveira Maria Paula Duarte José Luis Capelo-Martínez Carlos Lodeiro Javier Fernández-Lodeiro |
| author_sort | Silvia Nuti |
| collection | DOAJ |
| description | The global increase in multidrug-resistant bacteria poses a challenge to public health and requires the development of new antibacterial materials. In this study, we examined the bactericidal properties of mesoporous silica-coated silver nanoparticles, varying the core sizes (ca. 28 nm and 51 nm). We also investigated gold nanoparticles (ca. 26 nm) coated with mesoporous silica as possible inert metal cores. To investigate the modification of antimicrobial activity after the surface charge change, we used silver nanoparticles with a silver core of 28 nm coated with a mesoporous shell (ca. 16 nm) and functionalized with a terminal amine group. Furthermore, we developed a facile method to create mesoporous silica-coated silver nanoparticles (Ag@mSiO<sub>2</sub>) doped films using polyurethane (IROGRAN<sup>®</sup>) as a polymer matrix via solution casting. The antibacterial effects of silver nanoparticles with different core sizes were analyzed against Gram-negative and Gram-positive bacteria relevant to the healthcare and food industry. The results demonstrated that gold nanoparticles were inert, while silver nanoparticles exhibited antibacterial effects against Gram-negative (<i>Escherichia coli</i> and <i>Salmonella enterica</i> subsp. <i>enterica</i> serovar Choleraesuis) and Gram-positive (<i>Bacillus cereus</i>) strains. In particular, the larger Ag@mSiO<sub>2</sub> nanoparticles showed a minimum inhibitory concentration (MIC) and a minimum bactericidal concentration (MBC) of 18 µg/mL in the <i>Salmonella</i> strain. Furthermore, upon terminal amine functionalization, reversing the surface charge to positive values, there was a significant increase in the antibacterial activity of the NPs compared to their negative counterparts. Finally, the antimicrobial properties of the nanoparticle-doped polyurethane films revealed a substantial improvement in antibacterial efficacy. This study provides valuable information on the potential of mesoporous silica-coated silver nanoparticles and their applications in fighting multidrug-resistant bacteria, especially in the healthcare and food industries. |
| first_indexed | 2024-04-25T00:23:25Z |
| format | Article |
| id | doaj.art-80c284f3b9a344f485de3bde2a0debbf |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-04-25T00:23:25Z |
| publishDate | 2024-03-01 |
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| spelling | doaj.art-80c284f3b9a344f485de3bde2a0debbf2024-03-12T16:51:40ZengMDPI AGNanomaterials2079-49912024-03-0114546210.3390/nano14050462Tailoring Mesoporous Silica-Coated Silver Nanoparticles and Polyurethane-Doped Films for Enhanced Antimicrobial ApplicationsSilvia Nuti0Adrián Fernández-Lodeiro1Joana Galhano2Elisabete Oliveira3Maria Paula Duarte4José Luis Capelo-Martínez5Carlos Lodeiro6Javier Fernández-Lodeiro7BIOSCOPE Research Group, LAQV-REQUIMTE, Chemistry Department, NOVA School of Science and Technology (FCT NOVA), Universidade NOVA de Lisboa, 2829-516 Caparica, PortugalBIOSCOPE Research Group, LAQV-REQUIMTE, Chemistry Department, NOVA School of Science and Technology (FCT NOVA), Universidade NOVA de Lisboa, 2829-516 Caparica, PortugalBIOSCOPE Research Group, LAQV-REQUIMTE, Chemistry Department, NOVA School of Science and Technology (FCT NOVA), Universidade NOVA de Lisboa, 2829-516 Caparica, PortugalBIOSCOPE Research Group, LAQV-REQUIMTE, Chemistry Department, NOVA School of Science and Technology (FCT NOVA), Universidade NOVA de Lisboa, 2829-516 Caparica, PortugalMEtRICs, Chemistry Department, NOVA School of Science and Technology (FCT NOVA), Universidade NOVA de Lisboa, 2829-516 Caparica, PortugalBIOSCOPE Research Group, LAQV-REQUIMTE, Chemistry Department, NOVA School of Science and Technology (FCT NOVA), Universidade NOVA de Lisboa, 2829-516 Caparica, PortugalBIOSCOPE Research Group, LAQV-REQUIMTE, Chemistry Department, NOVA School of Science and Technology (FCT NOVA), Universidade NOVA de Lisboa, 2829-516 Caparica, PortugalBIOSCOPE Research Group, LAQV-REQUIMTE, Chemistry Department, NOVA School of Science and Technology (FCT NOVA), Universidade NOVA de Lisboa, 2829-516 Caparica, PortugalThe global increase in multidrug-resistant bacteria poses a challenge to public health and requires the development of new antibacterial materials. In this study, we examined the bactericidal properties of mesoporous silica-coated silver nanoparticles, varying the core sizes (ca. 28 nm and 51 nm). We also investigated gold nanoparticles (ca. 26 nm) coated with mesoporous silica as possible inert metal cores. To investigate the modification of antimicrobial activity after the surface charge change, we used silver nanoparticles with a silver core of 28 nm coated with a mesoporous shell (ca. 16 nm) and functionalized with a terminal amine group. Furthermore, we developed a facile method to create mesoporous silica-coated silver nanoparticles (Ag@mSiO<sub>2</sub>) doped films using polyurethane (IROGRAN<sup>®</sup>) as a polymer matrix via solution casting. The antibacterial effects of silver nanoparticles with different core sizes were analyzed against Gram-negative and Gram-positive bacteria relevant to the healthcare and food industry. The results demonstrated that gold nanoparticles were inert, while silver nanoparticles exhibited antibacterial effects against Gram-negative (<i>Escherichia coli</i> and <i>Salmonella enterica</i> subsp. <i>enterica</i> serovar Choleraesuis) and Gram-positive (<i>Bacillus cereus</i>) strains. In particular, the larger Ag@mSiO<sub>2</sub> nanoparticles showed a minimum inhibitory concentration (MIC) and a minimum bactericidal concentration (MBC) of 18 µg/mL in the <i>Salmonella</i> strain. Furthermore, upon terminal amine functionalization, reversing the surface charge to positive values, there was a significant increase in the antibacterial activity of the NPs compared to their negative counterparts. Finally, the antimicrobial properties of the nanoparticle-doped polyurethane films revealed a substantial improvement in antibacterial efficacy. This study provides valuable information on the potential of mesoporous silica-coated silver nanoparticles and their applications in fighting multidrug-resistant bacteria, especially in the healthcare and food industries.https://www.mdpi.com/2079-4991/14/5/462silver nanoparticlessilica core shellantimicrobial activitypolymersbacterialsgold nanoparticles |
| spellingShingle | Silvia Nuti Adrián Fernández-Lodeiro Joana Galhano Elisabete Oliveira Maria Paula Duarte José Luis Capelo-Martínez Carlos Lodeiro Javier Fernández-Lodeiro Tailoring Mesoporous Silica-Coated Silver Nanoparticles and Polyurethane-Doped Films for Enhanced Antimicrobial Applications Nanomaterials silver nanoparticles silica core shell antimicrobial activity polymers bacterials gold nanoparticles |
| title | Tailoring Mesoporous Silica-Coated Silver Nanoparticles and Polyurethane-Doped Films for Enhanced Antimicrobial Applications |
| title_full | Tailoring Mesoporous Silica-Coated Silver Nanoparticles and Polyurethane-Doped Films for Enhanced Antimicrobial Applications |
| title_fullStr | Tailoring Mesoporous Silica-Coated Silver Nanoparticles and Polyurethane-Doped Films for Enhanced Antimicrobial Applications |
| title_full_unstemmed | Tailoring Mesoporous Silica-Coated Silver Nanoparticles and Polyurethane-Doped Films for Enhanced Antimicrobial Applications |
| title_short | Tailoring Mesoporous Silica-Coated Silver Nanoparticles and Polyurethane-Doped Films for Enhanced Antimicrobial Applications |
| title_sort | tailoring mesoporous silica coated silver nanoparticles and polyurethane doped films for enhanced antimicrobial applications |
| topic | silver nanoparticles silica core shell antimicrobial activity polymers bacterials gold nanoparticles |
| url | https://www.mdpi.com/2079-4991/14/5/462 |
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