Is Alzhezimer’s disease a New Type Diabetes? Crosstalk between two serious disorders: review
Introduction and purpose: More and more reports suggest that diabetes plays an important role in the pathogenesis of Alzheimer's disease (AD). Understanding this link may provide a new approach to modulating the onset and progression of sporadic AD cases. The aim of the study is to present the...
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| Format: | Article |
| Language: | English |
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Kazimierz Wielki University
2023-01-01
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| Series: | Journal of Education, Health and Sport |
| Subjects: | |
| Online Access: | https://apcz.umk.pl/JEHS/article/view/41588 |
| _version_ | 1828051949423951872 |
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| author | Maciej Dobosz Gracjan Rudziński Zuzanna Chilimoniuk Piotr Więsyk Natalia Kusak Aleksandra Chałupnik |
| author_facet | Maciej Dobosz Gracjan Rudziński Zuzanna Chilimoniuk Piotr Więsyk Natalia Kusak Aleksandra Chałupnik |
| author_sort | Maciej Dobosz |
| collection | DOAJ |
| description |
Introduction and purpose: More and more reports suggest that diabetes plays an important role in the pathogenesis of Alzheimer's disease (AD). Understanding this link may provide a new approach to modulating the onset and progression of sporadic AD cases. The aim of the study is to present the current state of knowledge on the basic mechanisms and factors influencing the development of AD in patients with type 2 diabetes in the context of clinical practice.
State of knowledge: It is estimated that up to 80% of Alzheimer's patients have glucose intolerance or diabetes. Impaired insulin signaling can lead to abnormal processing and accumulation of beta-amyloid protein, which can result in memory deficits and cognitive decline. Insulin deficiency can also cause over-activity of the GSK3 enzyme, leading to tau hyperphosphorylation and senile plaque accumulation. Diabetes can also cause fibrotic changes in cerebral vessels, disrupting brain metabolism and potentially leading to hippocampus atrophy. The release of cytokines during the metabolic syndrome can also cause oxidative stress and neuroinflammation, which may contribute to neuronal atrophy. It has been reported that healthy diet, physical exercises and prevention of metabolic diseases may reduce the incidence of AD.
Conclusions: Epidemiological data and pathophysiological studies indicate a significant relationship between these diseases that AD is sometimes called Type 3 diabetes. Early detection of hyperglycemia and its proper management, may be crucial in the context of the clinical prevention of dementia diseases. It is essential to pay attention to the cognitive abilities of patients with metabolic diseases.
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| first_indexed | 2024-04-10T19:46:25Z |
| format | Article |
| id | doaj.art-80c909cee0134188890228dde5beaa56 |
| institution | Directory Open Access Journal |
| issn | 2391-8306 |
| language | English |
| last_indexed | 2024-04-10T19:46:25Z |
| publishDate | 2023-01-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj.art-80c909cee0134188890228dde5beaa562023-01-29T11:42:55ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062023-01-0113310.12775/JEHS.2023.13.03.017Is Alzhezimer’s disease a New Type Diabetes? Crosstalk between two serious disorders: reviewMaciej DoboszGracjan Rudziński0Zuzanna Chilimoniuk1Piotr Więsyk2Natalia Kusak3Aleksandra Chałupnik4Independent Public Clinical Hospital No. 4 in LublinStudents' Research Group at the Department of Family Medicine Medical University of LublinStudents' Research Group at the Department of Family Medicine Medical University of LublinStudents' Research Group at the Department of Family Medicine Medical University of LublinStudents' Research Group at the Department of Family Medicine Medical University of Lublin Introduction and purpose: More and more reports suggest that diabetes plays an important role in the pathogenesis of Alzheimer's disease (AD). Understanding this link may provide a new approach to modulating the onset and progression of sporadic AD cases. The aim of the study is to present the current state of knowledge on the basic mechanisms and factors influencing the development of AD in patients with type 2 diabetes in the context of clinical practice. State of knowledge: It is estimated that up to 80% of Alzheimer's patients have glucose intolerance or diabetes. Impaired insulin signaling can lead to abnormal processing and accumulation of beta-amyloid protein, which can result in memory deficits and cognitive decline. Insulin deficiency can also cause over-activity of the GSK3 enzyme, leading to tau hyperphosphorylation and senile plaque accumulation. Diabetes can also cause fibrotic changes in cerebral vessels, disrupting brain metabolism and potentially leading to hippocampus atrophy. The release of cytokines during the metabolic syndrome can also cause oxidative stress and neuroinflammation, which may contribute to neuronal atrophy. It has been reported that healthy diet, physical exercises and prevention of metabolic diseases may reduce the incidence of AD. Conclusions: Epidemiological data and pathophysiological studies indicate a significant relationship between these diseases that AD is sometimes called Type 3 diabetes. Early detection of hyperglycemia and its proper management, may be crucial in the context of the clinical prevention of dementia diseases. It is essential to pay attention to the cognitive abilities of patients with metabolic diseases. https://apcz.umk.pl/JEHS/article/view/41588DiabetesAlzheimer's diseaseoxidative stressmetabolic disorderscognitive disordersdementia |
| spellingShingle | Maciej Dobosz Gracjan Rudziński Zuzanna Chilimoniuk Piotr Więsyk Natalia Kusak Aleksandra Chałupnik Is Alzhezimer’s disease a New Type Diabetes? Crosstalk between two serious disorders: review Journal of Education, Health and Sport Diabetes Alzheimer's disease oxidative stress metabolic disorders cognitive disorders dementia |
| title | Is Alzhezimer’s disease a New Type Diabetes? Crosstalk between two serious disorders: review |
| title_full | Is Alzhezimer’s disease a New Type Diabetes? Crosstalk between two serious disorders: review |
| title_fullStr | Is Alzhezimer’s disease a New Type Diabetes? Crosstalk between two serious disorders: review |
| title_full_unstemmed | Is Alzhezimer’s disease a New Type Diabetes? Crosstalk between two serious disorders: review |
| title_short | Is Alzhezimer’s disease a New Type Diabetes? Crosstalk between two serious disorders: review |
| title_sort | is alzhezimer s disease a new type diabetes crosstalk between two serious disorders review |
| topic | Diabetes Alzheimer's disease oxidative stress metabolic disorders cognitive disorders dementia |
| url | https://apcz.umk.pl/JEHS/article/view/41588 |
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