Thymic Stromal Lymphopoietin Interferes with the Apoptosis of Human Skin Mast Cells by a Dual Strategy Involving STAT5/Mcl-1 and JNK/Bcl-x<sub>L</sub>

Thymic Stromal Lymphopoietin Interferes with the Apoptosis of Human Skin Mast Cells by a Dual Strategy Involving STAT5/Mcl-1 and JNK/Bcl-x<sub>L</sub>

Mast cells (MCs) play critical roles in allergic and inflammatory reactions and contribute to multiple pathologies in the skin, in which they show increased numbers, which frequently correlates with severity. It remains ill-defined how MC accumulation is established by the cutaneous microenvironment...

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Bibliographic Details
Main Authors: Tarek Hazzan, Jürgen Eberle, Margitta Worm, Magda Babina
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Cells
Subjects:
mast cells
TSLP
skin
apoptosis
survival
STAT5
JNK
Mcl-1
Bcl-x<sub>L</sub>
RNA interference
Online Access:https://www.mdpi.com/2073-4409/8/8/829

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