Involvement of the cerebellum in EMDR efficiency: a metabolic connectivity PET study in PTSD
Background We recently reported an improvement of precuneus PET metabolism after EMDR therapy in military participants suffering from PTSD. Objective The aim of the present study was to investigate the metabolic changes of precuneus connectivity in these participants after such treatment. Method Fif...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-12-01
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| Series: | European Journal of Psychotraumatology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/20008198.2020.1767986 |
| _version_ | 1797954521926729728 |
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| author | A. Verger P. F. Rousseau E. Malbos M. B. Chawki F. Nicolas C. Lançon S. Khalfa E. Guedj |
| author_facet | A. Verger P. F. Rousseau E. Malbos M. B. Chawki F. Nicolas C. Lançon S. Khalfa E. Guedj |
| author_sort | A. Verger |
| collection | DOAJ |
| description | Background We recently reported an improvement of precuneus PET metabolism after EMDR therapy in military participants suffering from PTSD. Objective The aim of the present study was to investigate the metabolic changes of precuneus connectivity in these participants after such treatment. Method Fifteen participants with PTSD performed a brain 18F-FDG-PET sensitized by virtual reality exposure to war scenes, before and after EMDR treatment. Inter-regional correlation analysis was performed to study metabolic changes of precuneus connectivity through SPMT maps at whole-brain level (p < 0.005 for the voxel, p < 0.05 for the cluster). Results A decrease of connectivity was observed after EMDR between the precuneus and two significant bilateral clusters of the cerebellum (bilateral Crus I and VI cerebellar lobules, Tmax voxel of 5.8 and 5.3, and cluster size of 343 and 314 voxels, respectively). Moreover, higher cerebellar metabolism before treatment was associated with reduced clinical PTSD scores after EMDR (p = 0.03). Conclusions The posterior cerebellum and its metabolic connectivity with the precuneus are involved in the clinical efficiency of EMDR in PTSD. |
| first_indexed | 2024-04-10T23:18:49Z |
| format | Article |
| id | doaj.art-80c95945ee604a019258e168a3d4aeb6 |
| institution | Directory Open Access Journal |
| issn | 2000-8066 |
| language | English |
| last_indexed | 2024-04-10T23:18:49Z |
| publishDate | 2020-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | European Journal of Psychotraumatology |
| spelling | doaj.art-80c95945ee604a019258e168a3d4aeb62023-01-12T15:31:32ZengTaylor & Francis GroupEuropean Journal of Psychotraumatology2000-80662020-12-0111110.1080/20008198.2020.17679861767986Involvement of the cerebellum in EMDR efficiency: a metabolic connectivity PET study in PTSDA. Verger0P. F. Rousseau1E. Malbos2M. B. Chawki3F. Nicolas4C. Lançon5S. Khalfa6E. Guedj7Lorraine UniversityAix-Marseille Université CNRSLa Conception University HospitalLorraine UniversityAix-Marseille UniversitéLa Conception University HospitalAix-Marseille Université CNRSHôpital d’Instruction des Armées Sainte-AnneBackground We recently reported an improvement of precuneus PET metabolism after EMDR therapy in military participants suffering from PTSD. Objective The aim of the present study was to investigate the metabolic changes of precuneus connectivity in these participants after such treatment. Method Fifteen participants with PTSD performed a brain 18F-FDG-PET sensitized by virtual reality exposure to war scenes, before and after EMDR treatment. Inter-regional correlation analysis was performed to study metabolic changes of precuneus connectivity through SPMT maps at whole-brain level (p < 0.005 for the voxel, p < 0.05 for the cluster). Results A decrease of connectivity was observed after EMDR between the precuneus and two significant bilateral clusters of the cerebellum (bilateral Crus I and VI cerebellar lobules, Tmax voxel of 5.8 and 5.3, and cluster size of 343 and 314 voxels, respectively). Moreover, higher cerebellar metabolism before treatment was associated with reduced clinical PTSD scores after EMDR (p = 0.03). Conclusions The posterior cerebellum and its metabolic connectivity with the precuneus are involved in the clinical efficiency of EMDR in PTSD.http://dx.doi.org/10.1080/20008198.2020.1767986ptsdemdrpetconnectivitycerebellum |
| spellingShingle | A. Verger P. F. Rousseau E. Malbos M. B. Chawki F. Nicolas C. Lançon S. Khalfa E. Guedj Involvement of the cerebellum in EMDR efficiency: a metabolic connectivity PET study in PTSD European Journal of Psychotraumatology ptsd emdr pet connectivity cerebellum |
| title | Involvement of the cerebellum in EMDR efficiency: a metabolic connectivity PET study in PTSD |
| title_full | Involvement of the cerebellum in EMDR efficiency: a metabolic connectivity PET study in PTSD |
| title_fullStr | Involvement of the cerebellum in EMDR efficiency: a metabolic connectivity PET study in PTSD |
| title_full_unstemmed | Involvement of the cerebellum in EMDR efficiency: a metabolic connectivity PET study in PTSD |
| title_short | Involvement of the cerebellum in EMDR efficiency: a metabolic connectivity PET study in PTSD |
| title_sort | involvement of the cerebellum in emdr efficiency a metabolic connectivity pet study in ptsd |
| topic | ptsd emdr pet connectivity cerebellum |
| url | http://dx.doi.org/10.1080/20008198.2020.1767986 |
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