Naive T lymphocytes chemotax long distance to CCL21 but not to a source of bioactive S1P

Naive T lymphocytes chemotax long distance to CCL21 but not to a source of bioactive S1P

Summary: Naive T lymphocytes traffic through the organism in search for antigen, alternating between blood and secondary lymphoid organs. Lymphocyte homing to lymph nodes relies on CCL21 chemokine sensing by CCR7 receptors, while exit into efferent lymphatics relies on sphingolipid S1P sensing by S1...

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Bibliographic Details
Main Authors: Nicolas Garcia-Seyda, Solene Song, Valentine Seveau de Noray, Luc David-Broglio, Christoph Matti, Marc Artinger, Florian Dupuy, Martine Biarnes-Pelicot, Marie-Pierre Valignat, Daniel F. Legler, Marc Bajénoff, Olivier Theodoly
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:iScience
Subjects:
Immunity
Immune response
Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223017728

Internet

http://www.sciencedirect.com/science/article/pii/S2589004223017728

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