Mitotic DNA synthesis in response to replication stress requires the sequential action of DNA polymerases zeta and delta in human cells
DNA replication stress can generate under-replicated DNA regions which is fixed by an atypical form of DNA repair synthesis in mitosis (MiDAS). Here the authors show that translesion and replicative DNA polymerases cooperate via the POLD3 subunit to complete MiDAS in human cells.
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-35992-5 |
| _version_ | 1828035110324142080 |
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| author | Wei Wu Szymon A. Barwacz Rahul Bhowmick Katrine Lundgaard Marisa M. Gonçalves Dinis Malgorzata Clausen Masato T. Kanemaki Ying Liu |
| author_facet | Wei Wu Szymon A. Barwacz Rahul Bhowmick Katrine Lundgaard Marisa M. Gonçalves Dinis Malgorzata Clausen Masato T. Kanemaki Ying Liu |
| author_sort | Wei Wu |
| collection | DOAJ |
| description | DNA replication stress can generate under-replicated DNA regions which is fixed by an atypical form of DNA repair synthesis in mitosis (MiDAS). Here the authors show that translesion and replicative DNA polymerases cooperate via the POLD3 subunit to complete MiDAS in human cells. |
| first_indexed | 2024-04-10T15:43:16Z |
| format | Article |
| id | doaj.art-80ce209a25eb497e9f4c0330f98b1f7e |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-10T15:43:16Z |
| publishDate | 2023-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-80ce209a25eb497e9f4c0330f98b1f7e2023-02-12T12:16:45ZengNature PortfolioNature Communications2041-17232023-02-0114111710.1038/s41467-023-35992-5Mitotic DNA synthesis in response to replication stress requires the sequential action of DNA polymerases zeta and delta in human cellsWei Wu0Szymon A. Barwacz1Rahul Bhowmick2Katrine Lundgaard3Marisa M. Gonçalves Dinis4Malgorzata Clausen5Masato T. Kanemaki6Ying Liu7Center for Chromosome Stability, Department of Cellular and Molecular Medicine, University of CopenhagenCenter for Chromosome Stability, Department of Cellular and Molecular Medicine, University of CopenhagenCenter for Chromosome Stability, Department of Cellular and Molecular Medicine, University of CopenhagenCenter for Chromosome Stability, Department of Cellular and Molecular Medicine, University of CopenhagenCenter for Chromosome Stability, Department of Cellular and Molecular Medicine, University of CopenhagenCenter for Chromosome Stability, Department of Cellular and Molecular Medicine, University of CopenhagenDepartment of Chromosome Science, National Institute of Genetics, Research Organization of Information and Systems (ROIS)Center for Chromosome Stability, Department of Cellular and Molecular Medicine, University of CopenhagenDNA replication stress can generate under-replicated DNA regions which is fixed by an atypical form of DNA repair synthesis in mitosis (MiDAS). Here the authors show that translesion and replicative DNA polymerases cooperate via the POLD3 subunit to complete MiDAS in human cells.https://doi.org/10.1038/s41467-023-35992-5 |
| spellingShingle | Wei Wu Szymon A. Barwacz Rahul Bhowmick Katrine Lundgaard Marisa M. Gonçalves Dinis Malgorzata Clausen Masato T. Kanemaki Ying Liu Mitotic DNA synthesis in response to replication stress requires the sequential action of DNA polymerases zeta and delta in human cells Nature Communications |
| title | Mitotic DNA synthesis in response to replication stress requires the sequential action of DNA polymerases zeta and delta in human cells |
| title_full | Mitotic DNA synthesis in response to replication stress requires the sequential action of DNA polymerases zeta and delta in human cells |
| title_fullStr | Mitotic DNA synthesis in response to replication stress requires the sequential action of DNA polymerases zeta and delta in human cells |
| title_full_unstemmed | Mitotic DNA synthesis in response to replication stress requires the sequential action of DNA polymerases zeta and delta in human cells |
| title_short | Mitotic DNA synthesis in response to replication stress requires the sequential action of DNA polymerases zeta and delta in human cells |
| title_sort | mitotic dna synthesis in response to replication stress requires the sequential action of dna polymerases zeta and delta in human cells |
| url | https://doi.org/10.1038/s41467-023-35992-5 |
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