Genetic Analysis Reveals Differences in CD8<sup>+</sup> T Cell Epitope Regions That May Impact Cross-Reactivity of Vaccine-Induced T Cells against Wild-Type Mumps Viruses

Genetic Analysis Reveals Differences in CD8<sup>+</sup> T Cell Epitope Regions That May Impact Cross-Reactivity of Vaccine-Induced T Cells against Wild-Type Mumps Viruses

Nowadays, mumps is re-emerging in highly vaccinated populations. Waning of vaccine-induced immunity plays a role, but antigenic differences between vaccine and mumps outbreak strains could also contribute to reduced vaccine effectiveness. CD8<sup>+</sup> T cells play a critical role in i...

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Bibliographic Details
Main Authors: Patricia Kaaijk, Maarten E. Emmelot, Jeroen Kerkhof, Cécile A.C.M. van Els, Hugo D. Meiring, Jelle de Wit, Rogier Bodewes
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Vaccines
Subjects:
T cell epitopes
T cell response
cytotoxic CD8<sup>+</sup> T cells
mumps virus
Jeryl–Lynn mumps vaccine
wild-type strains
Online Access:https://www.mdpi.com/2076-393X/9/7/699

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