Challenging Diagnosis of Pure Erythroid Leukemia: A Case Report and Literature Review
Pure erythroid leukemia (PEL) is an extremely rare type of acute myeloid leukemia (AML), accounting for fewer than 1% of all AML cases. A 72-year-old man presented with severe fatigue. His bone marrow aspiration contained myeloperoxidase negative abnormal cells that were aggregating and depicting ep...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Hematology Reports |
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| Online Access: | https://www.mdpi.com/2038-8330/14/1/7 |
| _version_ | 1797471167297093632 |
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| author | Shingo Sato Masayuki Kobayashi Ken Suzaki Ittoku Nanke Nobuharu Kosugi |
| author_facet | Shingo Sato Masayuki Kobayashi Ken Suzaki Ittoku Nanke Nobuharu Kosugi |
| author_sort | Shingo Sato |
| collection | DOAJ |
| description | Pure erythroid leukemia (PEL) is an extremely rare type of acute myeloid leukemia (AML), accounting for fewer than 1% of all AML cases. A 72-year-old man presented with severe fatigue. His bone marrow aspiration contained myeloperoxidase negative abnormal cells that were aggregating and depicting epithelial adhesion, suggesting the possibility of solid tumor metastasis. His general condition deteriorated during medical diagnosis, and he died soon after starting chemotherapy. PEL appeared to be the definitive diagnosis after evaluating the histopathological findings, which were obtained after his death. With atypical morphological features, immunophenotypic and karyotypic approaches must be integrated for PEL assessment. |
| first_indexed | 2024-03-09T19:45:29Z |
| format | Article |
| id | doaj.art-80d02cfa026f4523a4953112fb6c4ff5 |
| institution | Directory Open Access Journal |
| issn | 2038-8330 |
| language | English |
| last_indexed | 2024-03-09T19:45:29Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Hematology Reports |
| spelling | doaj.art-80d02cfa026f4523a4953112fb6c4ff52023-11-24T01:24:29ZengMDPI AGHematology Reports2038-83302022-03-01141384410.3390/hematolrep14010007Challenging Diagnosis of Pure Erythroid Leukemia: A Case Report and Literature ReviewShingo Sato0Masayuki Kobayashi1Ken Suzaki2Ittoku Nanke3Nobuharu Kosugi4Department of Internal Medicine, Tokyo Metropolitan Bokutoh Hospital, Tokyo 130-8575, JapanDepartment of Hematology, Tokyo Metropolitan Bokutoh Hospital, Tokyo 130-8575, JapanDepartment of Hematology, Tokyo Metropolitan Bokutoh Hospital, Tokyo 130-8575, JapanDepartment of Internal Medicine, Tokyo Metropolitan Bokutoh Hospital, Tokyo 130-8575, JapanDepartment of Hematology, Tokyo Metropolitan Bokutoh Hospital, Tokyo 130-8575, JapanPure erythroid leukemia (PEL) is an extremely rare type of acute myeloid leukemia (AML), accounting for fewer than 1% of all AML cases. A 72-year-old man presented with severe fatigue. His bone marrow aspiration contained myeloperoxidase negative abnormal cells that were aggregating and depicting epithelial adhesion, suggesting the possibility of solid tumor metastasis. His general condition deteriorated during medical diagnosis, and he died soon after starting chemotherapy. PEL appeared to be the definitive diagnosis after evaluating the histopathological findings, which were obtained after his death. With atypical morphological features, immunophenotypic and karyotypic approaches must be integrated for PEL assessment.https://www.mdpi.com/2038-8330/14/1/7pure erythroid leukemiaPELacute myeloid leukemiaAMLepithelial tumor |
| spellingShingle | Shingo Sato Masayuki Kobayashi Ken Suzaki Ittoku Nanke Nobuharu Kosugi Challenging Diagnosis of Pure Erythroid Leukemia: A Case Report and Literature Review Hematology Reports pure erythroid leukemia PEL acute myeloid leukemia AML epithelial tumor |
| title | Challenging Diagnosis of Pure Erythroid Leukemia: A Case Report and Literature Review |
| title_full | Challenging Diagnosis of Pure Erythroid Leukemia: A Case Report and Literature Review |
| title_fullStr | Challenging Diagnosis of Pure Erythroid Leukemia: A Case Report and Literature Review |
| title_full_unstemmed | Challenging Diagnosis of Pure Erythroid Leukemia: A Case Report and Literature Review |
| title_short | Challenging Diagnosis of Pure Erythroid Leukemia: A Case Report and Literature Review |
| title_sort | challenging diagnosis of pure erythroid leukemia a case report and literature review |
| topic | pure erythroid leukemia PEL acute myeloid leukemia AML epithelial tumor |
| url | https://www.mdpi.com/2038-8330/14/1/7 |
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