SAPHO Syndrome with Palmoplantar Pustulosis as the First Manifestation Successfully Treated with Adalimumab
Qingyun Yang,1,* Tingkai Xiang,1,* Yangfan Wu,1,* Enyi Ye,1,* Beilei He,1,* Zhangyu Bu2,* 1Department of The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310006 People’s Republic of China; 2Department of...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-11-01
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| Series: | Clinical, Cosmetic and Investigational Dermatology |
| Subjects: | |
| Online Access: | https://www.dovepress.com/sapho-syndrome-with-palmoplantar-pustulosis-as-the-first-manifestation-peer-reviewed-fulltext-article-CCID |
| _version_ | 1811211914025369600 |
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| author | Yang Q Xiang T Wu Y Ye E He B Bu Z |
| author_facet | Yang Q Xiang T Wu Y Ye E He B Bu Z |
| author_sort | Yang Q |
| collection | DOAJ |
| description | Qingyun Yang,1,* Tingkai Xiang,1,* Yangfan Wu,1,* Enyi Ye,1,* Beilei He,1,* Zhangyu Bu2,* 1Department of The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310006 People’s Republic of China; 2Department of Dermatology, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhangyu Bu, Department of The Fourth School of Clinical Medicine, Zhejiang University School of Medicine, No. 261, Huansha Road, Hangzhou, Zhejiang, 310006, People’s Republic of China, Fax +8657156006617, Email buzyhz@163.comIntroduction: Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome is an acronym for synovitis, pustulosis, acne, hyperostosis, and osteitis, and clinically manifests as dermatological and musculoskeletal damage. Two major manifestations that co-occur in a single patient are rare.Methods/Results: This literature describes a 44-year-old male affected by SAPHO syndrome, whose first manifestation was palmoplantar pustulosis (PPP). Symptomatic treatments such as anti-inflammatory and analgesics did not work well for him. Adalimumab provided noteworthy improvement in the neck and thoracic back pain improvement after two weeks. The palmoplantar pustules were alleviated after four weeks.Conclusion: The literature on SAPHO syndrome therapy is increasing. Thus, adalimumab is a novel therapeutic agent. This report demonstrates the efficiency of adalimumab in SAPHO syndrome.Keywords: synovitis, acne, psoriasis, bone hypertrophy, osteitis, psoriasis arthritis, adalimumab |
| first_indexed | 2024-04-12T05:21:19Z |
| format | Article |
| id | doaj.art-80d09d5dcdd243199f6cbcbccff856f4 |
| institution | Directory Open Access Journal |
| issn | 1178-7015 |
| language | English |
| last_indexed | 2024-04-12T05:21:19Z |
| publishDate | 2022-11-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical, Cosmetic and Investigational Dermatology |
| spelling | doaj.art-80d09d5dcdd243199f6cbcbccff856f42022-12-22T03:46:28ZengDove Medical PressClinical, Cosmetic and Investigational Dermatology1178-70152022-11-01Volume 152547255479953SAPHO Syndrome with Palmoplantar Pustulosis as the First Manifestation Successfully Treated with AdalimumabYang QXiang TWu YYe EHe BBu ZQingyun Yang,1,* Tingkai Xiang,1,* Yangfan Wu,1,* Enyi Ye,1,* Beilei He,1,* Zhangyu Bu2,* 1Department of The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310006 People’s Republic of China; 2Department of Dermatology, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhangyu Bu, Department of The Fourth School of Clinical Medicine, Zhejiang University School of Medicine, No. 261, Huansha Road, Hangzhou, Zhejiang, 310006, People’s Republic of China, Fax +8657156006617, Email buzyhz@163.comIntroduction: Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome is an acronym for synovitis, pustulosis, acne, hyperostosis, and osteitis, and clinically manifests as dermatological and musculoskeletal damage. Two major manifestations that co-occur in a single patient are rare.Methods/Results: This literature describes a 44-year-old male affected by SAPHO syndrome, whose first manifestation was palmoplantar pustulosis (PPP). Symptomatic treatments such as anti-inflammatory and analgesics did not work well for him. Adalimumab provided noteworthy improvement in the neck and thoracic back pain improvement after two weeks. The palmoplantar pustules were alleviated after four weeks.Conclusion: The literature on SAPHO syndrome therapy is increasing. Thus, adalimumab is a novel therapeutic agent. This report demonstrates the efficiency of adalimumab in SAPHO syndrome.Keywords: synovitis, acne, psoriasis, bone hypertrophy, osteitis, psoriasis arthritis, adalimumabhttps://www.dovepress.com/sapho-syndrome-with-palmoplantar-pustulosis-as-the-first-manifestation-peer-reviewed-fulltext-article-CCIDsynovitisacnepsoriasisbone hypertrophyosteitispsoriasis arthritisadalimumab. |
| spellingShingle | Yang Q Xiang T Wu Y Ye E He B Bu Z SAPHO Syndrome with Palmoplantar Pustulosis as the First Manifestation Successfully Treated with Adalimumab Clinical, Cosmetic and Investigational Dermatology synovitis acne psoriasis bone hypertrophy osteitis psoriasis arthritis adalimumab. |
| title | SAPHO Syndrome with Palmoplantar Pustulosis as the First Manifestation Successfully Treated with Adalimumab |
| title_full | SAPHO Syndrome with Palmoplantar Pustulosis as the First Manifestation Successfully Treated with Adalimumab |
| title_fullStr | SAPHO Syndrome with Palmoplantar Pustulosis as the First Manifestation Successfully Treated with Adalimumab |
| title_full_unstemmed | SAPHO Syndrome with Palmoplantar Pustulosis as the First Manifestation Successfully Treated with Adalimumab |
| title_short | SAPHO Syndrome with Palmoplantar Pustulosis as the First Manifestation Successfully Treated with Adalimumab |
| title_sort | sapho syndrome with palmoplantar pustulosis as the first manifestation successfully treated with adalimumab |
| topic | synovitis acne psoriasis bone hypertrophy osteitis psoriasis arthritis adalimumab. |
| url | https://www.dovepress.com/sapho-syndrome-with-palmoplantar-pustulosis-as-the-first-manifestation-peer-reviewed-fulltext-article-CCID |
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