Rapid, enantioselective and colorimetric detection of D-arginine
Summary: D-amino acids are of biological significance yet are not clearly understood due to the lack of powerful analytical tools for their identification. Thus, the specific detection of a single enantiomer of a particular amino acid remains a great challenge due to their structural similarity. Her...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-09-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004222012366 |
| _version_ | 1818000663284547584 |
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| author | Xianzhe Yu Binjie Zhang Cailing Fan Qianqian Yan Shenglin Wang Hui Hu Qinxi Dong Gengyu Du Yanan Gao Chaoyuan Zeng |
| author_facet | Xianzhe Yu Binjie Zhang Cailing Fan Qianqian Yan Shenglin Wang Hui Hu Qinxi Dong Gengyu Du Yanan Gao Chaoyuan Zeng |
| author_sort | Xianzhe Yu |
| collection | DOAJ |
| description | Summary: D-amino acids are of biological significance yet are not clearly understood due to the lack of powerful analytical tools for their identification. Thus, the specific detection of a single enantiomer of a particular amino acid remains a great challenge due to their structural similarity. Here, we report a strategy to incorporate multiple reaction sites on a chiral 1,1′-bi-2,2′-naphthol-based fluorescent probe. It can respond specifically to D-arginine, while producing no response when in contact with all other amino acids. The probe can report arginine’s concentration, and enantiomeric configuration and colorimetric studies enable its qualitative determination. |
| first_indexed | 2024-04-14T03:24:27Z |
| format | Article |
| id | doaj.art-80d0c2251858464daf2aa5cd817d8cda |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-04-14T03:24:27Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-80d0c2251858464daf2aa5cd817d8cda2022-12-22T02:15:12ZengElsevieriScience2589-00422022-09-01259104964Rapid, enantioselective and colorimetric detection of D-arginineXianzhe Yu0Binjie Zhang1Cailing Fan2Qianqian Yan3Shenglin Wang4Hui Hu5Qinxi Dong6Gengyu Du7Yanan Gao8Chaoyuan Zeng9Key Laboratory of Ministry of Education for Advanced Materials in Tropical Island Resources, Collaborative Innovation Center of Ecological Civilization, Hainan University, No 58, Renmin Avenue, Haikou 570228, ChinaKey Laboratory of Ministry of Education for Advanced Materials in Tropical Island Resources, Collaborative Innovation Center of Ecological Civilization, Hainan University, No 58, Renmin Avenue, Haikou 570228, ChinaKey Laboratory of Ministry of Education for Advanced Materials in Tropical Island Resources, Collaborative Innovation Center of Ecological Civilization, Hainan University, No 58, Renmin Avenue, Haikou 570228, ChinaKey Laboratory of Ministry of Education for Advanced Materials in Tropical Island Resources, Collaborative Innovation Center of Ecological Civilization, Hainan University, No 58, Renmin Avenue, Haikou 570228, ChinaKey Laboratory of Ministry of Education for Advanced Materials in Tropical Island Resources, Collaborative Innovation Center of Ecological Civilization, Hainan University, No 58, Renmin Avenue, Haikou 570228, ChinaKey Laboratory of Ministry of Education for Advanced Materials in Tropical Island Resources, Collaborative Innovation Center of Ecological Civilization, Hainan University, No 58, Renmin Avenue, Haikou 570228, ChinaKey Laboratory of Ministry of Education for Advanced Materials in Tropical Island Resources, Collaborative Innovation Center of Ecological Civilization, Hainan University, No 58, Renmin Avenue, Haikou 570228, ChinaDepartment of Chemistry, University of Virginia, Charlottesville, VA 22904, USA; Corresponding authorKey Laboratory of Ministry of Education for Advanced Materials in Tropical Island Resources, Collaborative Innovation Center of Ecological Civilization, Hainan University, No 58, Renmin Avenue, Haikou 570228, China; Corresponding authorKey Laboratory of Ministry of Education for Advanced Materials in Tropical Island Resources, Collaborative Innovation Center of Ecological Civilization, Hainan University, No 58, Renmin Avenue, Haikou 570228, China; Corresponding authorSummary: D-amino acids are of biological significance yet are not clearly understood due to the lack of powerful analytical tools for their identification. Thus, the specific detection of a single enantiomer of a particular amino acid remains a great challenge due to their structural similarity. Here, we report a strategy to incorporate multiple reaction sites on a chiral 1,1′-bi-2,2′-naphthol-based fluorescent probe. It can respond specifically to D-arginine, while producing no response when in contact with all other amino acids. The probe can report arginine’s concentration, and enantiomeric configuration and colorimetric studies enable its qualitative determination.http://www.sciencedirect.com/science/article/pii/S2589004222012366ChemistryAnalytical chemistryAnalytical chemistry applications |
| spellingShingle | Xianzhe Yu Binjie Zhang Cailing Fan Qianqian Yan Shenglin Wang Hui Hu Qinxi Dong Gengyu Du Yanan Gao Chaoyuan Zeng Rapid, enantioselective and colorimetric detection of D-arginine iScience Chemistry Analytical chemistry Analytical chemistry applications |
| title | Rapid, enantioselective and colorimetric detection of D-arginine |
| title_full | Rapid, enantioselective and colorimetric detection of D-arginine |
| title_fullStr | Rapid, enantioselective and colorimetric detection of D-arginine |
| title_full_unstemmed | Rapid, enantioselective and colorimetric detection of D-arginine |
| title_short | Rapid, enantioselective and colorimetric detection of D-arginine |
| title_sort | rapid enantioselective and colorimetric detection of d arginine |
| topic | Chemistry Analytical chemistry Analytical chemistry applications |
| url | http://www.sciencedirect.com/science/article/pii/S2589004222012366 |
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