Exosomes Derived from Immune Cells: The New Role of Tumor Immune Microenvironment and Tumor Therapy
Shiyang Wang, Yue Shi Department of Geriatric Surgery, The First Hospital of China Medical University, Shenyang, 110001, People’s Republic of ChinaCorrespondence: Yue Shi, Department of Geriatric Surgery, The First Hospital of China Medical University, Shenyang, 110001, People’s...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-12-01
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| Series: | International Journal of Nanomedicine |
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| Online Access: | https://www.dovepress.com/exosomes-derived-from-immune-cells-the-new-role-of-tumor-immune-microe-peer-reviewed-fulltext-article-IJN |
| _version_ | 1797978975022088192 |
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| author | Wang S Shi Y |
| author_facet | Wang S Shi Y |
| author_sort | Wang S |
| collection | DOAJ |
| description | Shiyang Wang, Yue Shi Department of Geriatric Surgery, The First Hospital of China Medical University, Shenyang, 110001, People’s Republic of ChinaCorrespondence: Yue Shi, Department of Geriatric Surgery, The First Hospital of China Medical University, Shenyang, 110001, People’s Republic of China, Tel +86-13842073309, Email shiyuesk@qq.comAbstract: Exosomes are small vesicles secreted by living cells, with a typical lipid bilayer structure. They carry a variety of proteins, lipids, RNA and other important information, play an important role in the transmission of substances and information between cells, and gradually become a marker for early diagnosis of many diseases and an important tool in drug delivery system. Immune cells are an important part of tumor microenvironment, and they can affect tumor progression by secreting a variety of immunoreactive substances. This review focuses on the effects of various immune cell-derived exosomes on tumor cells, different immune cells and other stromal cells in tumor microenvironment. Exosomes derived from different immune cells can not only reshape a pro-inflammatory microenvironment to inhibit tumor progression, but also promote tumor progression by inhibiting the killing effect of NK cells, CD8+T cells and other cells or promoting tumor cells and immunosuppressive immune cells. In addition, we also discussed that some exosomes derived from immune cells (such as DC, M1 macrophages and neutrophils) play a tumor inhibitory role after being engineered.Keywords: tumor, exosome, tumor immunity, immune cells, engineered exosomes |
| first_indexed | 2024-04-11T05:31:35Z |
| format | Article |
| id | doaj.art-80d14fcb8dba475ba19cf91a6415adbb |
| institution | Directory Open Access Journal |
| issn | 1178-2013 |
| language | English |
| last_indexed | 2024-04-11T05:31:35Z |
| publishDate | 2022-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nanomedicine |
| spelling | doaj.art-80d14fcb8dba475ba19cf91a6415adbb2022-12-22T18:12:17ZengDove Medical PressInternational Journal of Nanomedicine1178-20132022-12-01Volume 176527655080510Exosomes Derived from Immune Cells: The New Role of Tumor Immune Microenvironment and Tumor TherapyWang SShi YShiyang Wang, Yue Shi Department of Geriatric Surgery, The First Hospital of China Medical University, Shenyang, 110001, People’s Republic of ChinaCorrespondence: Yue Shi, Department of Geriatric Surgery, The First Hospital of China Medical University, Shenyang, 110001, People’s Republic of China, Tel +86-13842073309, Email shiyuesk@qq.comAbstract: Exosomes are small vesicles secreted by living cells, with a typical lipid bilayer structure. They carry a variety of proteins, lipids, RNA and other important information, play an important role in the transmission of substances and information between cells, and gradually become a marker for early diagnosis of many diseases and an important tool in drug delivery system. Immune cells are an important part of tumor microenvironment, and they can affect tumor progression by secreting a variety of immunoreactive substances. This review focuses on the effects of various immune cell-derived exosomes on tumor cells, different immune cells and other stromal cells in tumor microenvironment. Exosomes derived from different immune cells can not only reshape a pro-inflammatory microenvironment to inhibit tumor progression, but also promote tumor progression by inhibiting the killing effect of NK cells, CD8+T cells and other cells or promoting tumor cells and immunosuppressive immune cells. In addition, we also discussed that some exosomes derived from immune cells (such as DC, M1 macrophages and neutrophils) play a tumor inhibitory role after being engineered.Keywords: tumor, exosome, tumor immunity, immune cells, engineered exosomeshttps://www.dovepress.com/exosomes-derived-from-immune-cells-the-new-role-of-tumor-immune-microe-peer-reviewed-fulltext-article-IJNtumorexosometumor immunityimmune cellsengineered exosomes. |
| spellingShingle | Wang S Shi Y Exosomes Derived from Immune Cells: The New Role of Tumor Immune Microenvironment and Tumor Therapy International Journal of Nanomedicine tumor exosome tumor immunity immune cells engineered exosomes. |
| title | Exosomes Derived from Immune Cells: The New Role of Tumor Immune Microenvironment and Tumor Therapy |
| title_full | Exosomes Derived from Immune Cells: The New Role of Tumor Immune Microenvironment and Tumor Therapy |
| title_fullStr | Exosomes Derived from Immune Cells: The New Role of Tumor Immune Microenvironment and Tumor Therapy |
| title_full_unstemmed | Exosomes Derived from Immune Cells: The New Role of Tumor Immune Microenvironment and Tumor Therapy |
| title_short | Exosomes Derived from Immune Cells: The New Role of Tumor Immune Microenvironment and Tumor Therapy |
| title_sort | exosomes derived from immune cells the new role of tumor immune microenvironment and tumor therapy |
| topic | tumor exosome tumor immunity immune cells engineered exosomes. |
| url | https://www.dovepress.com/exosomes-derived-from-immune-cells-the-new-role-of-tumor-immune-microe-peer-reviewed-fulltext-article-IJN |
| work_keys_str_mv | AT wangs exosomesderivedfromimmunecellsthenewroleoftumorimmunemicroenvironmentandtumortherapy AT shiy exosomesderivedfromimmunecellsthenewroleoftumorimmunemicroenvironmentandtumortherapy |