SPOP promotes ATF2 ubiquitination and degradation to suppress prostate cancer progression

SPOP promotes ATF2 ubiquitination and degradation to suppress prostate cancer progression

Abstract Background Next-generation sequencing of the exome and genome of prostate cancers has identified numerous genetic alterations. SPOP (Speckle-type POZ Protein) is one of the most frequently mutated genes in primary prostate cancer, suggesting that SPOP may be a potential driver of prostate c...

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Bibliographic Details
Main Authors: Jian Ma, Kun Chang, Jingtao Peng, Qing Shi, Hualei Gan, Kun Gao, Kai Feng, Fujiang Xu, Hailiang Zhang, Bo Dai, Yao Zhu, Guohai Shi, Yijun Shen, Yiping Zhu, Xiaojian Qin, Yao Li, Pingzhao Zhang, Dingwei Ye, Chenji Wang
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Prostate cancer
SPOP
ATF2
Ubiquitination
Proteasomal degradation
Online Access:http://link.springer.com/article/10.1186/s13046-018-0809-0

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http://link.springer.com/article/10.1186/s13046-018-0809-0

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