Cytochalasins as Modulators of Stem Cell Differentiation
Regenerative medicine aims to identify new research strategies for the repair and restoration of tissues damaged by pathological or accidental events. Mesenchymal stem cells (MSCs) play a key role in regenerative medicine approaches due to their specific properties, such as the high rate of prolifer...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-02-01
|
| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/13/5/400 |
| _version_ | 1797264724111392768 |
|---|---|
| author | Luca Pampanella Giovannamaria Petrocelli Provvidenza Maria Abruzzo Cinzia Zucchini Silvia Canaider Carlo Ventura Federica Facchin |
| author_facet | Luca Pampanella Giovannamaria Petrocelli Provvidenza Maria Abruzzo Cinzia Zucchini Silvia Canaider Carlo Ventura Federica Facchin |
| author_sort | Luca Pampanella |
| collection | DOAJ |
| description | Regenerative medicine aims to identify new research strategies for the repair and restoration of tissues damaged by pathological or accidental events. Mesenchymal stem cells (MSCs) play a key role in regenerative medicine approaches due to their specific properties, such as the high rate of proliferation, the ability to differentiate into several cell lineages, the immunomodulatory potential, and their easy isolation with minimal ethical issues. One of the main goals of regenerative medicine is to modulate, both in vitro and in vivo, the differentiation potential of MSCs to improve their use in the repair of damaged tissues. Over the years, much evidence has been collected about the ability of cytochalasins, a large family of 60 metabolites isolated mainly from fungi, to modulate multiple properties of stem cells (SCs), such as proliferation, migration, and differentiation, by altering the organization of the cyto- and the nucleo-skeleton. In this review, we discussed the ability of two different cytochalasins, cytochalasins D and B, to influence specific SC differentiation programs modulated by several agents (chemical or physical) or intra- and extra-cellular factors, with particular attention to human MSCs (hMSCs). |
| first_indexed | 2024-04-25T00:33:27Z |
| format | Article |
| id | doaj.art-80d70eb8c4ec499597d5e3e0220fdda4 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-04-25T00:33:27Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-80d70eb8c4ec499597d5e3e0220fdda42024-03-12T16:41:35ZengMDPI AGCells2073-44092024-02-0113540010.3390/cells13050400Cytochalasins as Modulators of Stem Cell DifferentiationLuca Pampanella0Giovannamaria Petrocelli1Provvidenza Maria Abruzzo2Cinzia Zucchini3Silvia Canaider4Carlo Ventura5Federica Facchin6Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Via Massarenti 9, 40138 Bologna, ItalyDepartment of Medical and Surgical Sciences (DIMEC), University of Bologna, Via Massarenti 9, 40138 Bologna, ItalyDepartment of Medical and Surgical Sciences (DIMEC), University of Bologna, Via Massarenti 9, 40138 Bologna, ItalyDepartment of Medical and Surgical Sciences (DIMEC), University of Bologna, Via Massarenti 9, 40138 Bologna, ItalyDepartment of Medical and Surgical Sciences (DIMEC), University of Bologna, Via Massarenti 9, 40138 Bologna, ItalyDepartment of Medical and Surgical Sciences (DIMEC), University of Bologna, Via Massarenti 9, 40138 Bologna, ItalyDepartment of Medical and Surgical Sciences (DIMEC), University of Bologna, Via Massarenti 9, 40138 Bologna, ItalyRegenerative medicine aims to identify new research strategies for the repair and restoration of tissues damaged by pathological or accidental events. Mesenchymal stem cells (MSCs) play a key role in regenerative medicine approaches due to their specific properties, such as the high rate of proliferation, the ability to differentiate into several cell lineages, the immunomodulatory potential, and their easy isolation with minimal ethical issues. One of the main goals of regenerative medicine is to modulate, both in vitro and in vivo, the differentiation potential of MSCs to improve their use in the repair of damaged tissues. Over the years, much evidence has been collected about the ability of cytochalasins, a large family of 60 metabolites isolated mainly from fungi, to modulate multiple properties of stem cells (SCs), such as proliferation, migration, and differentiation, by altering the organization of the cyto- and the nucleo-skeleton. In this review, we discussed the ability of two different cytochalasins, cytochalasins D and B, to influence specific SC differentiation programs modulated by several agents (chemical or physical) or intra- and extra-cellular factors, with particular attention to human MSCs (hMSCs).https://www.mdpi.com/2073-4409/13/5/400cytochalasinsstem cellsmesenchymal stem cellsmesenchymal stromal cellsactin microfilamentscytoskeleton |
| spellingShingle | Luca Pampanella Giovannamaria Petrocelli Provvidenza Maria Abruzzo Cinzia Zucchini Silvia Canaider Carlo Ventura Federica Facchin Cytochalasins as Modulators of Stem Cell Differentiation Cells cytochalasins stem cells mesenchymal stem cells mesenchymal stromal cells actin microfilaments cytoskeleton |
| title | Cytochalasins as Modulators of Stem Cell Differentiation |
| title_full | Cytochalasins as Modulators of Stem Cell Differentiation |
| title_fullStr | Cytochalasins as Modulators of Stem Cell Differentiation |
| title_full_unstemmed | Cytochalasins as Modulators of Stem Cell Differentiation |
| title_short | Cytochalasins as Modulators of Stem Cell Differentiation |
| title_sort | cytochalasins as modulators of stem cell differentiation |
| topic | cytochalasins stem cells mesenchymal stem cells mesenchymal stromal cells actin microfilaments cytoskeleton |
| url | https://www.mdpi.com/2073-4409/13/5/400 |
| work_keys_str_mv | AT lucapampanella cytochalasinsasmodulatorsofstemcelldifferentiation AT giovannamariapetrocelli cytochalasinsasmodulatorsofstemcelldifferentiation AT provvidenzamariaabruzzo cytochalasinsasmodulatorsofstemcelldifferentiation AT cinziazucchini cytochalasinsasmodulatorsofstemcelldifferentiation AT silviacanaider cytochalasinsasmodulatorsofstemcelldifferentiation AT carloventura cytochalasinsasmodulatorsofstemcelldifferentiation AT federicafacchin cytochalasinsasmodulatorsofstemcelldifferentiation |