High resolution crystal structure of the Grb2 SH2 domain with a phosphopeptide derived from CD28.

High resolution crystal structure of the Grb2 SH2 domain with a phosphopeptide derived from CD28.

Src homology 2 (SH2) domains play a critical role in cellular signal transduction. They bind to peptides containing phosphotyrosine (pY) with various specificities that depend on the flanking amino-acid residues. The SH2 domain of growth-factor receptor-bound protein 2 (Grb2) specifically recognizes...

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Bibliographic Details
Main Authors: Kunitake Higo, Teikichi Ikura, Masayuki Oda, Hisayuki Morii, Jun Takahashi, Ryo Abe, Nobutoshi Ito
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3787023?pdf=render

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