Phenomenology of delirium in decompensated liver disease patients-a prospective observational study
Background: Decompensated liver disease (DCLD) is associated with various cognitive changes. The present study aimed to estimate the prevalence, phenomenology, and course of delirium in decompensated liver disease patients. Methods: This prospective observational study was done on 111 patients admit...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Indian Psychiatric Society (Kerala State Branch
2021-10-01
|
| Series: | Kerala Journal of Psychiatry |
| Subjects: | |
| Online Access: | https://kjponline.com/index.php/kjp/article/view/285 |
| _version_ | 1818751575465656320 |
|---|---|
| author | B Lakshmi Dorai G Raghuthaman |
| author_facet | B Lakshmi Dorai G Raghuthaman |
| author_sort | B Lakshmi Dorai |
| collection | DOAJ |
| description | Background: Decompensated liver disease (DCLD) is associated with various cognitive changes. The present study aimed to estimate the prevalence, phenomenology, and course of delirium in decompensated liver disease patients. Methods: This prospective observational study was done on 111 patients admitted to the gastroenterology department with the diagnosis of DCLD. Richmond Agitation Sedation Scale (RASS) and confusion assessment method (CAM) were used to detect delirium for the first five consecutive days. Patients detected to be having delirium were administered a delirium rating scale (DRS) for the next seven days to evaluate the features of delirium. Descriptive analysis was carried out by mean and standard deviation for quantitative variables, frequency, and proportion for categorical variables. For normally distributed quantitative parameters, the mean values were compared using an independent sample t-test. Categorical outcomes were compared between study groups using the chi-square test. coGuide version V.1.0 was used for statistical analysis. Results: The prevalence of delirium among patients with DCLD was 34 (30.63%). All delirious patients continued to have delirium symptoms for the initial three days. Six patients remitted as early as the fourth day of DRS assessment, while nine patients continued to have delirium symptoms even by the seventh day of evaluation. Conclusion: Nearly one-third of patients with DCLD presented with delirium. They presented with insomnia, cognitive deficits, motor retardation, and minimal psychotic symptoms. Many patients completely recovered from delirium within a week, but a few had delirium up to the seventh day. |
| first_indexed | 2024-12-18T04:37:45Z |
| format | Article |
| id | doaj.art-80dbf9679b894ddeab1998dafa726f06 |
| institution | Directory Open Access Journal |
| issn | 0377-0699 2395-1486 |
| language | English |
| last_indexed | 2024-12-18T04:37:45Z |
| publishDate | 2021-10-01 |
| publisher | Indian Psychiatric Society (Kerala State Branch |
| record_format | Article |
| series | Kerala Journal of Psychiatry |
| spelling | doaj.art-80dbf9679b894ddeab1998dafa726f062022-12-21T21:20:48ZengIndian Psychiatric Society (Kerala State BranchKerala Journal of Psychiatry0377-06992395-14862021-10-0134211912610.30834/KJP.34.2.2021.285246Phenomenology of delirium in decompensated liver disease patients-a prospective observational studyB Lakshmi Dorai0https://orcid.org/0000-0002-0215-0462G Raghuthaman1Vinayaka Mission’s Kirupananda Variyar Medical College and Hospital, SalemDepartment of Psychiatry, PSG Institute of Medical Sciences & Research, CoimbatoreBackground: Decompensated liver disease (DCLD) is associated with various cognitive changes. The present study aimed to estimate the prevalence, phenomenology, and course of delirium in decompensated liver disease patients. Methods: This prospective observational study was done on 111 patients admitted to the gastroenterology department with the diagnosis of DCLD. Richmond Agitation Sedation Scale (RASS) and confusion assessment method (CAM) were used to detect delirium for the first five consecutive days. Patients detected to be having delirium were administered a delirium rating scale (DRS) for the next seven days to evaluate the features of delirium. Descriptive analysis was carried out by mean and standard deviation for quantitative variables, frequency, and proportion for categorical variables. For normally distributed quantitative parameters, the mean values were compared using an independent sample t-test. Categorical outcomes were compared between study groups using the chi-square test. coGuide version V.1.0 was used for statistical analysis. Results: The prevalence of delirium among patients with DCLD was 34 (30.63%). All delirious patients continued to have delirium symptoms for the initial three days. Six patients remitted as early as the fourth day of DRS assessment, while nine patients continued to have delirium symptoms even by the seventh day of evaluation. Conclusion: Nearly one-third of patients with DCLD presented with delirium. They presented with insomnia, cognitive deficits, motor retardation, and minimal psychotic symptoms. Many patients completely recovered from delirium within a week, but a few had delirium up to the seventh day.https://kjponline.com/index.php/kjp/article/view/285deliriumhepatitishepatic encephalopathycirrhosis |
| spellingShingle | B Lakshmi Dorai G Raghuthaman Phenomenology of delirium in decompensated liver disease patients-a prospective observational study Kerala Journal of Psychiatry delirium hepatitis hepatic encephalopathy cirrhosis |
| title | Phenomenology of delirium in decompensated liver disease patients-a prospective observational study |
| title_full | Phenomenology of delirium in decompensated liver disease patients-a prospective observational study |
| title_fullStr | Phenomenology of delirium in decompensated liver disease patients-a prospective observational study |
| title_full_unstemmed | Phenomenology of delirium in decompensated liver disease patients-a prospective observational study |
| title_short | Phenomenology of delirium in decompensated liver disease patients-a prospective observational study |
| title_sort | phenomenology of delirium in decompensated liver disease patients a prospective observational study |
| topic | delirium hepatitis hepatic encephalopathy cirrhosis |
| url | https://kjponline.com/index.php/kjp/article/view/285 |
| work_keys_str_mv | AT blakshmidorai phenomenologyofdeliriumindecompensatedliverdiseasepatientsaprospectiveobservationalstudy AT graghuthaman phenomenologyofdeliriumindecompensatedliverdiseasepatientsaprospectiveobservationalstudy |