Altered gene expression in the superior temporal gyrus in schizophrenia
<p>Abstract</p> <p>Background</p> <p>The superior temporal gyrus (STG), which encompasses the primary auditory cortex, is believed to be a major anatomical substrate for speech, language and communication. The STG connects to the limbic system (hippocampus and amygdala)...
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| Format: | Article |
| Language: | English |
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BMC
2008-04-01
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| Series: | BMC Genomics |
| Online Access: | http://www.biomedcentral.com/1471-2164/9/199 |
| _version_ | 1818664507656896512 |
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| author | Bowden Nikola A Scott Rodney J Tooney Paul A |
| author_facet | Bowden Nikola A Scott Rodney J Tooney Paul A |
| author_sort | Bowden Nikola A |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The superior temporal gyrus (STG), which encompasses the primary auditory cortex, is believed to be a major anatomical substrate for speech, language and communication. The STG connects to the limbic system (hippocampus and amygdala), the thalamus and neocortical association areas in the prefrontal cortex, all of which have been implicated in schizophrenia.</p> <p>Results</p> <p>To identify altered mRNA expression in the superior temporal gyrus (STG) in schizophrenia, oligonucleotide microarrays were used with RNA from postmortem STG tissue from 7 individuals with schizophrenia and 7 matched non-psychiatric controls. Overall, there was a trend towards down-regulation in gene expression, and altered expression of genes involved in neurotransmission, neurodevelopment, and presynaptic function was identified. To confirm altered expression identified by microarray analysis, the mRNA expression levels of four genes, IPLA2γ, PIK31R1, Lin-7b and ATBF1, were semi-quantitatively measured using relative real-time PCR. A number of genes with altered expression in the STG were also shown to have similar changes in expression as shown in our previous study of peripheral blood lymphocytes in schizophrenia.</p> <p>Conclusion</p> <p>This study has identified altered expression of genes in the STG involved in neurotransmission and neurodevelopment, and to a lesser extent presynaptic function, which further support the notion of these functions playing an integral role in the development of schizophrenia.</p> |
| first_indexed | 2024-12-17T05:33:51Z |
| format | Article |
| id | doaj.art-80dc1cf996f64214a41fad7e405ee504 |
| institution | Directory Open Access Journal |
| issn | 1471-2164 |
| language | English |
| last_indexed | 2024-12-17T05:33:51Z |
| publishDate | 2008-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Genomics |
| spelling | doaj.art-80dc1cf996f64214a41fad7e405ee5042022-12-21T22:01:40ZengBMCBMC Genomics1471-21642008-04-019119910.1186/1471-2164-9-199Altered gene expression in the superior temporal gyrus in schizophreniaBowden Nikola AScott Rodney JTooney Paul A<p>Abstract</p> <p>Background</p> <p>The superior temporal gyrus (STG), which encompasses the primary auditory cortex, is believed to be a major anatomical substrate for speech, language and communication. The STG connects to the limbic system (hippocampus and amygdala), the thalamus and neocortical association areas in the prefrontal cortex, all of which have been implicated in schizophrenia.</p> <p>Results</p> <p>To identify altered mRNA expression in the superior temporal gyrus (STG) in schizophrenia, oligonucleotide microarrays were used with RNA from postmortem STG tissue from 7 individuals with schizophrenia and 7 matched non-psychiatric controls. Overall, there was a trend towards down-regulation in gene expression, and altered expression of genes involved in neurotransmission, neurodevelopment, and presynaptic function was identified. To confirm altered expression identified by microarray analysis, the mRNA expression levels of four genes, IPLA2γ, PIK31R1, Lin-7b and ATBF1, were semi-quantitatively measured using relative real-time PCR. A number of genes with altered expression in the STG were also shown to have similar changes in expression as shown in our previous study of peripheral blood lymphocytes in schizophrenia.</p> <p>Conclusion</p> <p>This study has identified altered expression of genes in the STG involved in neurotransmission and neurodevelopment, and to a lesser extent presynaptic function, which further support the notion of these functions playing an integral role in the development of schizophrenia.</p>http://www.biomedcentral.com/1471-2164/9/199 |
| spellingShingle | Bowden Nikola A Scott Rodney J Tooney Paul A Altered gene expression in the superior temporal gyrus in schizophrenia BMC Genomics |
| title | Altered gene expression in the superior temporal gyrus in schizophrenia |
| title_full | Altered gene expression in the superior temporal gyrus in schizophrenia |
| title_fullStr | Altered gene expression in the superior temporal gyrus in schizophrenia |
| title_full_unstemmed | Altered gene expression in the superior temporal gyrus in schizophrenia |
| title_short | Altered gene expression in the superior temporal gyrus in schizophrenia |
| title_sort | altered gene expression in the superior temporal gyrus in schizophrenia |
| url | http://www.biomedcentral.com/1471-2164/9/199 |
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