tRNA-Derived Fragments (tRFs): Emerging New Roles for an Ancient RNA in the Regulation of Gene Expression
This review will summarise the recent discoveries and current state of research on short noncoding RNAs derived from tRNAs—known as tRNA-derived fragments (tRFs). It will describe the features of the known subtypes of these RNAs; including sequence characteristics, protein interactors, expression ch...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-11-01
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| Series: | Life |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2075-1729/5/4/1638 |
| _version_ | 1811302443874516992 |
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| author | Simon P. Keam Gyorgy Hutvagner |
| author_facet | Simon P. Keam Gyorgy Hutvagner |
| author_sort | Simon P. Keam |
| collection | DOAJ |
| description | This review will summarise the recent discoveries and current state of research on short noncoding RNAs derived from tRNAs—known as tRNA-derived fragments (tRFs). It will describe the features of the known subtypes of these RNAs; including sequence characteristics, protein interactors, expression characteristics, biogenesis, and similarity to canonical miRNA pathways. Also their role in regulating gene expression; including mediating translational suppression, will be discussed. We also highlight their potential use as biomarkers, functions in gene regulation and links to disease. Finally, this review will speculate as to the origin and rationale for the conservation of this novel class of noncoding RNAs amongst both prokaryotes and eukaryotes. |
| first_indexed | 2024-04-13T07:27:54Z |
| format | Article |
| id | doaj.art-80dcc2b043494dd0a70a0a4add4295d0 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-04-13T07:27:54Z |
| publishDate | 2015-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-80dcc2b043494dd0a70a0a4add4295d02022-12-22T02:56:26ZengMDPI AGLife2075-17292015-11-01541638165110.3390/life5041638life5041638tRNA-Derived Fragments (tRFs): Emerging New Roles for an Ancient RNA in the Regulation of Gene ExpressionSimon P. Keam0Gyorgy Hutvagner1Centre for Health Technologies, Faculty of Engineering and Information Technology, University of Technology Sydney, Ultimo 2007, AustraliaCentre for Health Technologies, Faculty of Engineering and Information Technology, University of Technology Sydney, Ultimo 2007, AustraliaThis review will summarise the recent discoveries and current state of research on short noncoding RNAs derived from tRNAs—known as tRNA-derived fragments (tRFs). It will describe the features of the known subtypes of these RNAs; including sequence characteristics, protein interactors, expression characteristics, biogenesis, and similarity to canonical miRNA pathways. Also their role in regulating gene expression; including mediating translational suppression, will be discussed. We also highlight their potential use as biomarkers, functions in gene regulation and links to disease. Finally, this review will speculate as to the origin and rationale for the conservation of this novel class of noncoding RNAs amongst both prokaryotes and eukaryotes.http://www.mdpi.com/2075-1729/5/4/1638tRNA-derived fragmentstRFtRNAsmall RNAgene regulation |
| spellingShingle | Simon P. Keam Gyorgy Hutvagner tRNA-Derived Fragments (tRFs): Emerging New Roles for an Ancient RNA in the Regulation of Gene Expression Life tRNA-derived fragments tRF tRNA small RNA gene regulation |
| title | tRNA-Derived Fragments (tRFs): Emerging New Roles for an Ancient RNA in the Regulation of Gene Expression |
| title_full | tRNA-Derived Fragments (tRFs): Emerging New Roles for an Ancient RNA in the Regulation of Gene Expression |
| title_fullStr | tRNA-Derived Fragments (tRFs): Emerging New Roles for an Ancient RNA in the Regulation of Gene Expression |
| title_full_unstemmed | tRNA-Derived Fragments (tRFs): Emerging New Roles for an Ancient RNA in the Regulation of Gene Expression |
| title_short | tRNA-Derived Fragments (tRFs): Emerging New Roles for an Ancient RNA in the Regulation of Gene Expression |
| title_sort | trna derived fragments trfs emerging new roles for an ancient rna in the regulation of gene expression |
| topic | tRNA-derived fragments tRF tRNA small RNA gene regulation |
| url | http://www.mdpi.com/2075-1729/5/4/1638 |
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