Structural basis of the farnesoid X receptor/retinoid X receptor heterodimer on inverted repeat DNA

Structural basis of the farnesoid X receptor/retinoid X receptor heterodimer on inverted repeat DNA

Farnesoid X receptor (FXR) is a ligand-activated transcription factor known as bile acid receptor (BAR). FXR plays critical roles in various biological processes, including metabolism, immune inflammation, liver regeneration and liver carcinogenesis. FXR forms a heterodimer with the retinoid X recep...

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Bibliographic Details
Main Authors: Longying Jiang, Xueke Liu, Xujun Liang, Shuyan Dai, Hudie Wei, Ming Guo, Zhuchu Chen, Desheng Xiao, Yongheng Chen
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Farnesoid X receptor
Retinoid X receptor
Heterodimer
Inverted repeat DNA
Crystal structure
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037023002088

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