Evidence of an association between the O blood group and allergic rhinitis
OBJECTIVE: The aim of this study was to verify if ABO phenotypes are associated with allergic rhinitis. METHODS: 168 patients with allergic rhinitis and 168 control individuals from the same geographical region and paired by gender and age were enrolled in the study. ABO phenotypes were identified i...
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| Format: | Article |
| Language: | English |
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Elsevier
2011-12-01
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| Series: | Revista Brasileira de Hematologia e Hemoterapia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842011000600013 |
| _version_ | 1811331534777483264 |
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| author | Nelson Falsarella Ana Iara da Costa Ferreira Fabiana Nakashima Cinara de Cássia Brandão de Mattos Luiz Carlos de Mattos |
| author_facet | Nelson Falsarella Ana Iara da Costa Ferreira Fabiana Nakashima Cinara de Cássia Brandão de Mattos Luiz Carlos de Mattos |
| author_sort | Nelson Falsarella |
| collection | DOAJ |
| description | OBJECTIVE: The aim of this study was to verify if ABO phenotypes are associated with allergic rhinitis. METHODS: 168 patients with allergic rhinitis and 168 control individuals from the same geographical region and paired by gender and age were enrolled in the study. ABO phenotypes were identified in red blood cells using the hemagglutination technique. The Fisher exact and chi-squared tests were employed to compare proportions. Statistical significance was set for an alpha error of 5% (p-value < 0.05). RESULTS: The overall differences in the frequencies of the ABO phenotypes of patients and controls were marginal (χ2: 7.569; degrees of freedom (DF): 3; p-value = 0.055) however the O blood group was associated with allergic rhinitis (χ2: 5.764; DF: 1; p-value = 0.016; OR: 1.735; CI 95%: 1.127-2.673). The differences in the frequencies of the O phenotype in patients and controls were statistically different for men (χ2: 8.520; DF: 1; p-value = 0.003) but not for women (χ2: 0.6375; DF: 1; p-value = 0.4246). The A phenotype was associated with protection (OR: 0.4385; CI 95%: 0.2043-0.9415; p-value = 0.049) and the O phenotype was associated with susceptibility (OR = 2.789; CI 95%: 1.385-5.616; p-value = 0.005) to allergic rhinitis only for men. CONCLUSION: The O blood group phenotype is associated with allergic rhinitis in male but not in female patients. |
| first_indexed | 2024-04-13T16:22:03Z |
| format | Article |
| id | doaj.art-80e02e96a98c490fa76699653242eb77 |
| institution | Directory Open Access Journal |
| issn | 1516-8484 1806-0870 |
| language | English |
| last_indexed | 2024-04-13T16:22:03Z |
| publishDate | 2011-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Revista Brasileira de Hematologia e Hemoterapia |
| spelling | doaj.art-80e02e96a98c490fa76699653242eb772022-12-22T02:39:54ZengElsevierRevista Brasileira de Hematologia e Hemoterapia1516-84841806-08702011-12-0133644444810.5581/1516-8484.20110120Evidence of an association between the O blood group and allergic rhinitisNelson FalsarellaAna Iara da Costa FerreiraFabiana NakashimaCinara de Cássia Brandão de MattosLuiz Carlos de MattosOBJECTIVE: The aim of this study was to verify if ABO phenotypes are associated with allergic rhinitis. METHODS: 168 patients with allergic rhinitis and 168 control individuals from the same geographical region and paired by gender and age were enrolled in the study. ABO phenotypes were identified in red blood cells using the hemagglutination technique. The Fisher exact and chi-squared tests were employed to compare proportions. Statistical significance was set for an alpha error of 5% (p-value < 0.05). RESULTS: The overall differences in the frequencies of the ABO phenotypes of patients and controls were marginal (χ2: 7.569; degrees of freedom (DF): 3; p-value = 0.055) however the O blood group was associated with allergic rhinitis (χ2: 5.764; DF: 1; p-value = 0.016; OR: 1.735; CI 95%: 1.127-2.673). The differences in the frequencies of the O phenotype in patients and controls were statistically different for men (χ2: 8.520; DF: 1; p-value = 0.003) but not for women (χ2: 0.6375; DF: 1; p-value = 0.4246). The A phenotype was associated with protection (OR: 0.4385; CI 95%: 0.2043-0.9415; p-value = 0.049) and the O phenotype was associated with susceptibility (OR = 2.789; CI 95%: 1.385-5.616; p-value = 0.005) to allergic rhinitis only for men. CONCLUSION: The O blood group phenotype is associated with allergic rhinitis in male but not in female patients.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842011000600013Rhinitis, allergic, seasonalBlood group antigensABO blood-group systemRespiratory hypersensitivityAsthma |
| spellingShingle | Nelson Falsarella Ana Iara da Costa Ferreira Fabiana Nakashima Cinara de Cássia Brandão de Mattos Luiz Carlos de Mattos Evidence of an association between the O blood group and allergic rhinitis Revista Brasileira de Hematologia e Hemoterapia Rhinitis, allergic, seasonal Blood group antigens ABO blood-group system Respiratory hypersensitivity Asthma |
| title | Evidence of an association between the O blood group and allergic rhinitis |
| title_full | Evidence of an association between the O blood group and allergic rhinitis |
| title_fullStr | Evidence of an association between the O blood group and allergic rhinitis |
| title_full_unstemmed | Evidence of an association between the O blood group and allergic rhinitis |
| title_short | Evidence of an association between the O blood group and allergic rhinitis |
| title_sort | evidence of an association between the o blood group and allergic rhinitis |
| topic | Rhinitis, allergic, seasonal Blood group antigens ABO blood-group system Respiratory hypersensitivity Asthma |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842011000600013 |
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