Parthenolide Suppresses T Helper 17 and Alleviates Experimental Autoimmune Encephalomyelitis

Parthenolide Suppresses T Helper 17 and Alleviates Experimental Autoimmune Encephalomyelitis

T helper (Th) cells play crucial roles in inflammation and adaptive immune system. Importantly, Th17 cells, a major pathogenic Th cell subset, are involved in the pathogenesis of multiple sclerosis (MS) and its classical animal modal experimental autoimmune encephalomyelitis (EAE). Previous studies...

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Bibliographic Details
Main Authors: Zhihui Zhang, Kai Zhang, Mi Zhang, Xiaomin Zhang, Rongxin Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Immunology
Subjects:
multiple sclerosis (MS) disease
T helper 17 cell (Th17 cell)
parthenolide (PTL)
nuclear factor kappa B (NF-κB)
experimental autoimmune encephalomyelitis (EAE)
retinoid-related orphan receptor-γt (RORγt)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.856694/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.856694/full

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