Sperm Differentiation from a Cytoskeletal Perspective with a Focus on the Microtubulome: A New Window into Unknown Aspects of Male Infertility
According to the World Health Organization, infertility refers to a couple's inability to conceive following at least one year of regular unprotected sexual intercourse. Male infertility accounts for about half of the various causes of couples' infertility. This review aimed to investigate...
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Isfahan University of Medical Sciences
2000-09-01
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| Series: | مجله دانشکده پزشکی اصفهان |
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| Online Access: | https://jims.mui.ac.ir/article_26229_2ae4957b611708f10f0abbc7f05fa8a1.pdf |
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| author | Mina Za,mani Almasi Samaneh Aghajanpour Elham Hosseini Mahshid Bazrafkan Amir Shaker Marjan Sabbaghian Mohammad Hossein Nasr Esfahani |
| author_facet | Mina Za,mani Almasi Samaneh Aghajanpour Elham Hosseini Mahshid Bazrafkan Amir Shaker Marjan Sabbaghian Mohammad Hossein Nasr Esfahani |
| author_sort | Mina Za,mani Almasi |
| collection | DOAJ |
| description | According to the World Health Organization, infertility refers to a couple's inability to conceive following at least one year of regular unprotected sexual intercourse. Male infertility accounts for about half of the various causes of couples' infertility. This review aimed to investigate the cellular and molecular differentiation of spermatozoa, focusing on the structure of the cytoskeleton, microtubules, actin filaments, motor, and non-motor proteins, to study the known genes associated with their formation and function, as well as the proteins involved in intracellular cargo transport, and ultimately investigate their essential role in maintaining sperm morphology and motility and subsequent male reproduction and infertility. The importance of microtubules in the critical processes of sperm production, transformation, maturation, and fertility of spermatozoa is such that the term "microtubule" has been recently used to denote the microtubule and all microtubule-related components in the sperm cell. The cellular process of sperm evolution and differentiation was discussed first, followed by a description of the cytoskeletal system of the acroframosome-acroplaxome-manchette axis, which is involved in acrosome formation and development, sperm head and flagellum shaping mechanisms, in response to the current and future demands of infertility researchers and clinicians in this emerging field of research. The significance of the aberrant function of different components of the sperm cytoskeleton in creating major disorders associated with male infertility was next inspected to clarify the ambiguous aspects of this complex process. |
| first_indexed | 2024-03-12T05:15:43Z |
| format | Article |
| id | doaj.art-80e2cf5610a14acc87c5a7d8cfb37b5c |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T05:15:43Z |
| publishDate | 2000-09-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-80e2cf5610a14acc87c5a7d8cfb37b5c2023-09-03T08:09:16ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2000-09-014069080081710.48305/jims.v40.i690.080026229Sperm Differentiation from a Cytoskeletal Perspective with a Focus on the Microtubulome: A New Window into Unknown Aspects of Male InfertilityMina Za,mani Almasi0Samaneh Aghajanpour1Elham Hosseini2Mahshid Bazrafkan3Amir Shaker4Marjan Sabbaghian5Mohammad Hossein Nasr Esfahani6MSc, Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, IranPhD Student of Reproductive Biology, Department of Anatomy, School of Medicine, Iran University of Medical Sciences and Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, IranAssistant Professor, Department of Obstetrics and Gynecology, Mousavi Hospital, School of Medicine, Zanjan University of Medical Sciences, Zanjan, IranAssistant Professor, Reproductive Biotechnology Research Center, Avicenna Research Institute (ARI), ACECR, Tehran, IranMSc, Department of Anatomy, School of Medicine, Iran University of Medical Sciences, Tehran, IranAssociate Professor, Department of Andrology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, IranProfessor, Department of Animal Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, IranAccording to the World Health Organization, infertility refers to a couple's inability to conceive following at least one year of regular unprotected sexual intercourse. Male infertility accounts for about half of the various causes of couples' infertility. This review aimed to investigate the cellular and molecular differentiation of spermatozoa, focusing on the structure of the cytoskeleton, microtubules, actin filaments, motor, and non-motor proteins, to study the known genes associated with their formation and function, as well as the proteins involved in intracellular cargo transport, and ultimately investigate their essential role in maintaining sperm morphology and motility and subsequent male reproduction and infertility. The importance of microtubules in the critical processes of sperm production, transformation, maturation, and fertility of spermatozoa is such that the term "microtubule" has been recently used to denote the microtubule and all microtubule-related components in the sperm cell. The cellular process of sperm evolution and differentiation was discussed first, followed by a description of the cytoskeletal system of the acroframosome-acroplaxome-manchette axis, which is involved in acrosome formation and development, sperm head and flagellum shaping mechanisms, in response to the current and future demands of infertility researchers and clinicians in this emerging field of research. The significance of the aberrant function of different components of the sperm cytoskeleton in creating major disorders associated with male infertility was next inspected to clarify the ambiguous aspects of this complex process.https://jims.mui.ac.ir/article_26229_2ae4957b611708f10f0abbc7f05fa8a1.pdfspermatozoaspermatogenesismicrotubulescytoskeletonacrosome |
| spellingShingle | Mina Za,mani Almasi Samaneh Aghajanpour Elham Hosseini Mahshid Bazrafkan Amir Shaker Marjan Sabbaghian Mohammad Hossein Nasr Esfahani Sperm Differentiation from a Cytoskeletal Perspective with a Focus on the Microtubulome: A New Window into Unknown Aspects of Male Infertility مجله دانشکده پزشکی اصفهان spermatozoa spermatogenesis microtubules cytoskeleton acrosome |
| title | Sperm Differentiation from a Cytoskeletal Perspective with a Focus on the Microtubulome: A New Window into Unknown Aspects of Male Infertility |
| title_full | Sperm Differentiation from a Cytoskeletal Perspective with a Focus on the Microtubulome: A New Window into Unknown Aspects of Male Infertility |
| title_fullStr | Sperm Differentiation from a Cytoskeletal Perspective with a Focus on the Microtubulome: A New Window into Unknown Aspects of Male Infertility |
| title_full_unstemmed | Sperm Differentiation from a Cytoskeletal Perspective with a Focus on the Microtubulome: A New Window into Unknown Aspects of Male Infertility |
| title_short | Sperm Differentiation from a Cytoskeletal Perspective with a Focus on the Microtubulome: A New Window into Unknown Aspects of Male Infertility |
| title_sort | sperm differentiation from a cytoskeletal perspective with a focus on the microtubulome a new window into unknown aspects of male infertility |
| topic | spermatozoa spermatogenesis microtubules cytoskeleton acrosome |
| url | https://jims.mui.ac.ir/article_26229_2ae4957b611708f10f0abbc7f05fa8a1.pdf |
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