Capsid-mediated control of adeno-associated viral transcription determines host range

Capsid-mediated control of adeno-associated viral transcription determines host range

Summary: Adeno-associated virus (AAV) is a member of the genus Dependoparvovirus, which infects a wide range of vertebrate species. Here, we observe that, unlike most primate AAV isolates, avian AAV is transcriptionally silenced in human cells. By swapping the VP1 N terminus from primate AAVs (e.g.,...

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Bibliographic Details
Main Authors: Ezra J. Loeb, Patrick L. Havlik, Zachary C. Elmore, Alan Rosales, Sophia M. Fergione, Trevor J. Gonzalez, Timothy J. Smith, Abigail R. Benkert, David N. Fiflis, Aravind Asokan
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Cell Reports
Subjects:
CP: Microbiology
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724002304

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