The use of real time strain endometrial elastosonography plus endometrial thickness and vascularization flow index to predict endometrial receptivity in IVF treatments: a pilot study
Abstract Background The usefulness of endometrium strain elastosonography (SE) for the evaluation of endometrial receptivity in women undergoing in vitro fertilization (IVF) remains controversial. The objective of this prospective, observational study was to evaluate the correlation between endometr...
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | BMC Medical Imaging |
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| Online Access: | https://doi.org/10.1186/s12880-023-01071-w |
| _version_ | 1797555672918786048 |
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| author | Antonio Stanziano Francesco Paolo Bianchi Anna Maria Caringella Clementina Cantatore Antonio D’Amato Angela Vitti Anna Cortone Amerigo Vitagliano Giuseppe D’Amato |
| author_facet | Antonio Stanziano Francesco Paolo Bianchi Anna Maria Caringella Clementina Cantatore Antonio D’Amato Angela Vitti Anna Cortone Amerigo Vitagliano Giuseppe D’Amato |
| author_sort | Antonio Stanziano |
| collection | DOAJ |
| description | Abstract Background The usefulness of endometrium strain elastosonography (SE) for the evaluation of endometrial receptivity in women undergoing in vitro fertilization (IVF) remains controversial. The objective of this prospective, observational study was to evaluate the correlation between endometrial thickness (EMT) and its related strain (ESR) on the day of ovulation triggering (hCG-d) and in vitro fertilization outcomes. Additionally, 3D Power Doppler vascular indices (3DPDVI) were also analysed. Methods We included all the patients undergoing fresh IVF-single blastocyst transfer cycle from January 2021 to August 2021 at our center. On hCG-d, after B-mode scanning was completed to measure the EMT, the mode was changed to elastosonography to evaluate the ESR (ratio between endometrial tissue and the myometrium below). At the end of examination, the Endometrial Volume (EV) and 3DPDVI (vascularization index [VI], flow index [FI] and vascularization flow index [VFI]), were assessed. Statistical analysis was completed using STATA MP16 software. Results A total number of 57 women were included. Based on the EMT on hCG-d, women were divided into two groups, Group 1: <7 mm and Group 2 ≥ 7 mm. Women with EMT < 7 mm had a significantly higher ESR (p = 0.004) and lower pregnancy rate (p = 0.04). Additionally, low ESR values were correlated with high VFI values (rho = -0.8; 95% CI = -0.9- -0.6; p < 0.0001) and EMT ≥ 7 mm could be predicted by low ESR (OR = 0.01; 95% CI = 0.01–0.30; p = 0.008, area under the ROC curve: 0.70). After all, in multiple logistic regression analysis, low values of ESR (p = 0.050) and high values of EMT (p = 0.051) on hCG-d had borderline statistical effects on pregnancy rate. Conclusions The ESR may be useful to improve the ultrasound evaluation of the endometrial quality in infertile women candidates to IVF/ICS. Given the small sample size of our study, the usefulness of strain elastosonography in this patients, needs further investigation. |
| first_indexed | 2024-03-10T16:50:51Z |
| format | Article |
| id | doaj.art-80e6e772b8644d0584d0d3d502e282cc |
| institution | Directory Open Access Journal |
| issn | 1471-2342 |
| language | English |
| last_indexed | 2024-03-10T16:50:51Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medical Imaging |
| spelling | doaj.art-80e6e772b8644d0584d0d3d502e282cc2023-11-20T11:18:53ZengBMCBMC Medical Imaging1471-23422023-09-0123111010.1186/s12880-023-01071-wThe use of real time strain endometrial elastosonography plus endometrial thickness and vascularization flow index to predict endometrial receptivity in IVF treatments: a pilot studyAntonio Stanziano0Francesco Paolo Bianchi1Anna Maria Caringella2Clementina Cantatore3Antonio D’Amato4Angela Vitti5Anna Cortone6Amerigo Vitagliano7Giuseppe D’Amato8Department of Advanced Reproductive Risk Management and High-Risk Pregnancies, ASL Bari, Reproductive and IVF Unit, PTA ConversanoDepartment of Interdisciplinary MedicineDepartment of Advanced Reproductive Risk Management and High-Risk Pregnancies, ASL Bari, Reproductive and IVF Unit, PTA ConversanoDepartment of Advanced Reproductive Risk Management and High-Risk Pregnancies, ASL Bari, Reproductive and IVF Unit, PTA ConversanoGynecology and Obstetrics Clinic, University of BariDepartment of Advanced Reproductive Risk Management and High-Risk Pregnancies, ASL Bari, Reproductive and IVF Unit, PTA ConversanoDepartment of Advanced Reproductive Risk Management and High-Risk Pregnancies, ASL Bari, Reproductive and IVF Unit, PTA ConversanoGynecology and Obstetrics Clinic, University of BariDepartment of Advanced Reproductive Risk Management and High-Risk Pregnancies, ASL Bari, Reproductive and IVF Unit, PTA ConversanoAbstract Background The usefulness of endometrium strain elastosonography (SE) for the evaluation of endometrial receptivity in women undergoing in vitro fertilization (IVF) remains controversial. The objective of this prospective, observational study was to evaluate the correlation between endometrial thickness (EMT) and its related strain (ESR) on the day of ovulation triggering (hCG-d) and in vitro fertilization outcomes. Additionally, 3D Power Doppler vascular indices (3DPDVI) were also analysed. Methods We included all the patients undergoing fresh IVF-single blastocyst transfer cycle from January 2021 to August 2021 at our center. On hCG-d, after B-mode scanning was completed to measure the EMT, the mode was changed to elastosonography to evaluate the ESR (ratio between endometrial tissue and the myometrium below). At the end of examination, the Endometrial Volume (EV) and 3DPDVI (vascularization index [VI], flow index [FI] and vascularization flow index [VFI]), were assessed. Statistical analysis was completed using STATA MP16 software. Results A total number of 57 women were included. Based on the EMT on hCG-d, women were divided into two groups, Group 1: <7 mm and Group 2 ≥ 7 mm. Women with EMT < 7 mm had a significantly higher ESR (p = 0.004) and lower pregnancy rate (p = 0.04). Additionally, low ESR values were correlated with high VFI values (rho = -0.8; 95% CI = -0.9- -0.6; p < 0.0001) and EMT ≥ 7 mm could be predicted by low ESR (OR = 0.01; 95% CI = 0.01–0.30; p = 0.008, area under the ROC curve: 0.70). After all, in multiple logistic regression analysis, low values of ESR (p = 0.050) and high values of EMT (p = 0.051) on hCG-d had borderline statistical effects on pregnancy rate. Conclusions The ESR may be useful to improve the ultrasound evaluation of the endometrial quality in infertile women candidates to IVF/ICS. Given the small sample size of our study, the usefulness of strain elastosonography in this patients, needs further investigation.https://doi.org/10.1186/s12880-023-01071-wEndometrial thicknessStrain elastosonographyEndometrial vascularityEndometrial receptivityIVF cyclesPregnancy rate. |
| spellingShingle | Antonio Stanziano Francesco Paolo Bianchi Anna Maria Caringella Clementina Cantatore Antonio D’Amato Angela Vitti Anna Cortone Amerigo Vitagliano Giuseppe D’Amato The use of real time strain endometrial elastosonography plus endometrial thickness and vascularization flow index to predict endometrial receptivity in IVF treatments: a pilot study BMC Medical Imaging Endometrial thickness Strain elastosonography Endometrial vascularity Endometrial receptivity IVF cycles Pregnancy rate. |
| title | The use of real time strain endometrial elastosonography plus endometrial thickness and vascularization flow index to predict endometrial receptivity in IVF treatments: a pilot study |
| title_full | The use of real time strain endometrial elastosonography plus endometrial thickness and vascularization flow index to predict endometrial receptivity in IVF treatments: a pilot study |
| title_fullStr | The use of real time strain endometrial elastosonography plus endometrial thickness and vascularization flow index to predict endometrial receptivity in IVF treatments: a pilot study |
| title_full_unstemmed | The use of real time strain endometrial elastosonography plus endometrial thickness and vascularization flow index to predict endometrial receptivity in IVF treatments: a pilot study |
| title_short | The use of real time strain endometrial elastosonography plus endometrial thickness and vascularization flow index to predict endometrial receptivity in IVF treatments: a pilot study |
| title_sort | use of real time strain endometrial elastosonography plus endometrial thickness and vascularization flow index to predict endometrial receptivity in ivf treatments a pilot study |
| topic | Endometrial thickness Strain elastosonography Endometrial vascularity Endometrial receptivity IVF cycles Pregnancy rate. |
| url | https://doi.org/10.1186/s12880-023-01071-w |
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