Evidence of Orientation-Dependent Early States of Prion Protein Misfolded Structures from Single Molecule Force Spectroscopy

Evidence of Orientation-Dependent Early States of Prion Protein Misfolded Structures from Single Molecule Force Spectroscopy

Prion diseases are neurodegenerative disorders characterized by the presence of oligomers and amyloid fibrils. These are the result of protein aggregation processes of the cellular prion protein (PrP<sup>C</sup>) into amyloidal forms denoted as prions or PrP<sup>Sc</sup>. We...

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Bibliographic Details
Main Authors: Andrea Raspadori, Valentina Vignali, Anna Murello, Gabriele Giachin, Bruno Samorì, Motomasa Tanaka, Carlos Bustamante, Giampaolo Zuccheri, Giuseppe Legname
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Biology
Subjects:
prions
atomic force microscopy
single molecule force spectroscopy
protein misfolding
intrinsically disordered proteins
Online Access:https://www.mdpi.com/2079-7737/11/9/1358

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