Antioxidant isolated from Schisandra propinqua (Wall.) Baill

Schisandra propinqua (Wall.) Baill.(Schisandraceae) is widely used as a Chinese folk medicine. In this study, activity-guided fractionation of the ethanol extract from the stem of Schisandra propinqua led to the isolation of four extracts. Subsequently, a neolignan 4,4-di(4-hydroxy-3-methoxyphenly)-...

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Main Authors: FENG HUANG, LIJIA XU, SHI GANGGANG
Format: Article
Language:English
Published: BMC 2009-01-01
Series:Biological Research
Subjects:
Online Access:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602009000300009
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author FENG HUANG
LIJIA XU
SHI GANGGANG
author_facet FENG HUANG
LIJIA XU
SHI GANGGANG
author_sort FENG HUANG
collection DOAJ
description Schisandra propinqua (Wall.) Baill.(Schisandraceae) is widely used as a Chinese folk medicine. In this study, activity-guided fractionation of the ethanol extract from the stem of Schisandra propinqua led to the isolation of four extracts. Subsequently, a neolignan 4,4-di(4-hydroxy-3-methoxyphenly)-2,3-dimethylbutanol was isolated from the EtOAc part of the stem of Schisandra propinqua, the free radical scavenging activities of which were researched in vitro. The present work demonstrated that extracts and pure compound possessed scavenging activities to DPPH, superoxide anions and hydroxy radical, and could depress lipid peroxidation reaction induced by oxygen radical produced by the Fe2+/cysteine system in vitro. This suggests that the traditional application of Schisandra propinqua in China may be related to its antioxidant activities, and the EtOAc part of the stems of Schisandra propinqua can be utilized as an effective source of antioxidants.
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spelling doaj.art-80e8427ace24479f8d30d414c5070a992022-12-22T00:49:32ZengBMCBiological Research0716-97600717-62872009-01-01423351356Antioxidant isolated from Schisandra propinqua (Wall.) BaillFENG HUANGLIJIA XUSHI GANGGANGSchisandra propinqua (Wall.) Baill.(Schisandraceae) is widely used as a Chinese folk medicine. In this study, activity-guided fractionation of the ethanol extract from the stem of Schisandra propinqua led to the isolation of four extracts. Subsequently, a neolignan 4,4-di(4-hydroxy-3-methoxyphenly)-2,3-dimethylbutanol was isolated from the EtOAc part of the stem of Schisandra propinqua, the free radical scavenging activities of which were researched in vitro. The present work demonstrated that extracts and pure compound possessed scavenging activities to DPPH, superoxide anions and hydroxy radical, and could depress lipid peroxidation reaction induced by oxygen radical produced by the Fe2+/cysteine system in vitro. This suggests that the traditional application of Schisandra propinqua in China may be related to its antioxidant activities, and the EtOAc part of the stems of Schisandra propinqua can be utilized as an effective source of antioxidants.http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602009000300009antioxidantfree radicallipid peroxidationSchisandra propinqua
spellingShingle FENG HUANG
LIJIA XU
SHI GANGGANG
Antioxidant isolated from Schisandra propinqua (Wall.) Baill
Biological Research
antioxidant
free radical
lipid peroxidation
Schisandra propinqua
title Antioxidant isolated from Schisandra propinqua (Wall.) Baill
title_full Antioxidant isolated from Schisandra propinqua (Wall.) Baill
title_fullStr Antioxidant isolated from Schisandra propinqua (Wall.) Baill
title_full_unstemmed Antioxidant isolated from Schisandra propinqua (Wall.) Baill
title_short Antioxidant isolated from Schisandra propinqua (Wall.) Baill
title_sort antioxidant isolated from schisandra propinqua wall baill
topic antioxidant
free radical
lipid peroxidation
Schisandra propinqua
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602009000300009
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AT lijiaxu antioxidantisolatedfromschisandrapropinquawallbaill
AT shiganggang antioxidantisolatedfromschisandrapropinquawallbaill