Antioxidant isolated from Schisandra propinqua (Wall.) Baill
Schisandra propinqua (Wall.) Baill.(Schisandraceae) is widely used as a Chinese folk medicine. In this study, activity-guided fractionation of the ethanol extract from the stem of Schisandra propinqua led to the isolation of four extracts. Subsequently, a neolignan 4,4-di(4-hydroxy-3-methoxyphenly)-...
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BMC
2009-01-01
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Series: | Biological Research |
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Online Access: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602009000300009 |
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author | FENG HUANG LIJIA XU SHI GANGGANG |
author_facet | FENG HUANG LIJIA XU SHI GANGGANG |
author_sort | FENG HUANG |
collection | DOAJ |
description | Schisandra propinqua (Wall.) Baill.(Schisandraceae) is widely used as a Chinese folk medicine. In this study, activity-guided fractionation of the ethanol extract from the stem of Schisandra propinqua led to the isolation of four extracts. Subsequently, a neolignan 4,4-di(4-hydroxy-3-methoxyphenly)-2,3-dimethylbutanol was isolated from the EtOAc part of the stem of Schisandra propinqua, the free radical scavenging activities of which were researched in vitro. The present work demonstrated that extracts and pure compound possessed scavenging activities to DPPH, superoxide anions and hydroxy radical, and could depress lipid peroxidation reaction induced by oxygen radical produced by the Fe2+/cysteine system in vitro. This suggests that the traditional application of Schisandra propinqua in China may be related to its antioxidant activities, and the EtOAc part of the stems of Schisandra propinqua can be utilized as an effective source of antioxidants. |
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issn | 0716-9760 0717-6287 |
language | English |
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publishDate | 2009-01-01 |
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spelling | doaj.art-80e8427ace24479f8d30d414c5070a992022-12-22T00:49:32ZengBMCBiological Research0716-97600717-62872009-01-01423351356Antioxidant isolated from Schisandra propinqua (Wall.) BaillFENG HUANGLIJIA XUSHI GANGGANGSchisandra propinqua (Wall.) Baill.(Schisandraceae) is widely used as a Chinese folk medicine. In this study, activity-guided fractionation of the ethanol extract from the stem of Schisandra propinqua led to the isolation of four extracts. Subsequently, a neolignan 4,4-di(4-hydroxy-3-methoxyphenly)-2,3-dimethylbutanol was isolated from the EtOAc part of the stem of Schisandra propinqua, the free radical scavenging activities of which were researched in vitro. The present work demonstrated that extracts and pure compound possessed scavenging activities to DPPH, superoxide anions and hydroxy radical, and could depress lipid peroxidation reaction induced by oxygen radical produced by the Fe2+/cysteine system in vitro. This suggests that the traditional application of Schisandra propinqua in China may be related to its antioxidant activities, and the EtOAc part of the stems of Schisandra propinqua can be utilized as an effective source of antioxidants.http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602009000300009antioxidantfree radicallipid peroxidationSchisandra propinqua |
spellingShingle | FENG HUANG LIJIA XU SHI GANGGANG Antioxidant isolated from Schisandra propinqua (Wall.) Baill Biological Research antioxidant free radical lipid peroxidation Schisandra propinqua |
title | Antioxidant isolated from Schisandra propinqua (Wall.) Baill |
title_full | Antioxidant isolated from Schisandra propinqua (Wall.) Baill |
title_fullStr | Antioxidant isolated from Schisandra propinqua (Wall.) Baill |
title_full_unstemmed | Antioxidant isolated from Schisandra propinqua (Wall.) Baill |
title_short | Antioxidant isolated from Schisandra propinqua (Wall.) Baill |
title_sort | antioxidant isolated from schisandra propinqua wall baill |
topic | antioxidant free radical lipid peroxidation Schisandra propinqua |
url | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602009000300009 |
work_keys_str_mv | AT fenghuang antioxidantisolatedfromschisandrapropinquawallbaill AT lijiaxu antioxidantisolatedfromschisandrapropinquawallbaill AT shiganggang antioxidantisolatedfromschisandrapropinquawallbaill |