Noncanonical genomic imprinting in the monoamine system determines naturalistic foraging and brain-adrenal axis functions
Summary: Noncanonical genomic imprinting can cause biased expression of one parental allele in a tissue; however, the functional relevance of such biases is unclear. To investigate ethological roles for noncanonical imprinting in dopa decarboxylase (Ddc) and tyrosine hydroxylase (Th), we use machine...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-03-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124722002364 |
| _version_ | 1828490451889422336 |
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| author | Paul J. Bonthuis Susan Steinwand Cornelia N. Stacher Hörndli Jared Emery Wei-Chao Huang Stephanie Kravitz Elliott Ferris Christopher Gregg |
| author_facet | Paul J. Bonthuis Susan Steinwand Cornelia N. Stacher Hörndli Jared Emery Wei-Chao Huang Stephanie Kravitz Elliott Ferris Christopher Gregg |
| author_sort | Paul J. Bonthuis |
| collection | DOAJ |
| description | Summary: Noncanonical genomic imprinting can cause biased expression of one parental allele in a tissue; however, the functional relevance of such biases is unclear. To investigate ethological roles for noncanonical imprinting in dopa decarboxylase (Ddc) and tyrosine hydroxylase (Th), we use machine learning to decompose naturalistic foraging in maternal and paternal allele mutant heterozygous mice. We uncover distinct roles for the maternal versus paternal alleles on foraging, where maternal alleles affect sons while daughters are under paternal allelic control. Each parental allele controls specific action sequences reflecting decisions in naive or familiar contexts. The maternal Ddc allele is preferentially expressed in subsets of hypothalamic GABAergic neurons, while the paternal allele predominates in subsets of adrenal cells. Each Ddc allele affects distinct molecular and endocrine components of the brain-adrenal axis. Thus, monoaminergic noncanonical imprinting has ethological roles in foraging and endocrine functions and operates by affecting discrete subsets of cells. |
| first_indexed | 2024-12-11T10:43:51Z |
| format | Article |
| id | doaj.art-80e897921e7743a7b88649d4a8a36b5e |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-11T10:43:51Z |
| publishDate | 2022-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-80e897921e7743a7b88649d4a8a36b5e2022-12-22T01:10:31ZengElsevierCell Reports2211-12472022-03-013810110500Noncanonical genomic imprinting in the monoamine system determines naturalistic foraging and brain-adrenal axis functionsPaul J. Bonthuis0Susan Steinwand1Cornelia N. Stacher Hörndli2Jared Emery3Wei-Chao Huang4Stephanie Kravitz5Elliott Ferris6Christopher Gregg7Department of Comparative Biosciences, University of Illinois at Urbana-Champaign College of Veterinary Medicine, Urbana, IL, USADepartment of Neurobiology, University of Utah School of Medicine, Room 408B, Biopolymers Research Building, Bld. 570, 20 South 2030 East, Salt Lake City, UT 84112, USADepartment of Neurobiology, University of Utah School of Medicine, Room 408B, Biopolymers Research Building, Bld. 570, 20 South 2030 East, Salt Lake City, UT 84112, USADepartment of Neurobiology, University of Utah School of Medicine, Room 408B, Biopolymers Research Building, Bld. 570, 20 South 2030 East, Salt Lake City, UT 84112, USADepartment of Neurobiology, University of Utah School of Medicine, Room 408B, Biopolymers Research Building, Bld. 570, 20 South 2030 East, Salt Lake City, UT 84112, USADepartment of Neurobiology, University of Utah School of Medicine, Room 408B, Biopolymers Research Building, Bld. 570, 20 South 2030 East, Salt Lake City, UT 84112, USA; Department of Human Genetics, University of Utah School of Medicine, Room 408B, Biopolymers Research Building, Bld. 570, 20 South 2030 East, Salt Lake City, UT 84112, USADepartment of Neurobiology, University of Utah School of Medicine, Room 408B, Biopolymers Research Building, Bld. 570, 20 South 2030 East, Salt Lake City, UT 84112, USADepartment of Neurobiology, University of Utah School of Medicine, Room 408B, Biopolymers Research Building, Bld. 570, 20 South 2030 East, Salt Lake City, UT 84112, USA; Department of Human Genetics, University of Utah School of Medicine, Room 408B, Biopolymers Research Building, Bld. 570, 20 South 2030 East, Salt Lake City, UT 84112, USA; Corresponding authorSummary: Noncanonical genomic imprinting can cause biased expression of one parental allele in a tissue; however, the functional relevance of such biases is unclear. To investigate ethological roles for noncanonical imprinting in dopa decarboxylase (Ddc) and tyrosine hydroxylase (Th), we use machine learning to decompose naturalistic foraging in maternal and paternal allele mutant heterozygous mice. We uncover distinct roles for the maternal versus paternal alleles on foraging, where maternal alleles affect sons while daughters are under paternal allelic control. Each parental allele controls specific action sequences reflecting decisions in naive or familiar contexts. The maternal Ddc allele is preferentially expressed in subsets of hypothalamic GABAergic neurons, while the paternal allele predominates in subsets of adrenal cells. Each Ddc allele affects distinct molecular and endocrine components of the brain-adrenal axis. Thus, monoaminergic noncanonical imprinting has ethological roles in foraging and endocrine functions and operates by affecting discrete subsets of cells.http://www.sciencedirect.com/science/article/pii/S2211124722002364genomic imprintingepigeneticsforagingmonoamineadrenalinetyrosine hydroxylase |
| spellingShingle | Paul J. Bonthuis Susan Steinwand Cornelia N. Stacher Hörndli Jared Emery Wei-Chao Huang Stephanie Kravitz Elliott Ferris Christopher Gregg Noncanonical genomic imprinting in the monoamine system determines naturalistic foraging and brain-adrenal axis functions Cell Reports genomic imprinting epigenetics foraging monoamine adrenaline tyrosine hydroxylase |
| title | Noncanonical genomic imprinting in the monoamine system determines naturalistic foraging and brain-adrenal axis functions |
| title_full | Noncanonical genomic imprinting in the monoamine system determines naturalistic foraging and brain-adrenal axis functions |
| title_fullStr | Noncanonical genomic imprinting in the monoamine system determines naturalistic foraging and brain-adrenal axis functions |
| title_full_unstemmed | Noncanonical genomic imprinting in the monoamine system determines naturalistic foraging and brain-adrenal axis functions |
| title_short | Noncanonical genomic imprinting in the monoamine system determines naturalistic foraging and brain-adrenal axis functions |
| title_sort | noncanonical genomic imprinting in the monoamine system determines naturalistic foraging and brain adrenal axis functions |
| topic | genomic imprinting epigenetics foraging monoamine adrenaline tyrosine hydroxylase |
| url | http://www.sciencedirect.com/science/article/pii/S2211124722002364 |
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