MUCOADHESIVE DELIVERY SYSTEMS USING CARRAGEENAN AND EUDRAGIT RLPO
The objective of this research is a bioadhesive two layers controlled release tablets. The drug release and the physical properties of tablet formulations using two polymers (Carrageenan 934 and Eudragit RL PO) at three levels and at a combination of different ratios of the two polymers were eval...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Universidad de Antioquia
2009-02-01
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| Series: | Vitae |
| Subjects: | |
| Online Access: | https://revistas.udea.edu.co/index.php/vitae/article/view/508 |
| _version_ | 1831629878351364096 |
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| author | Gloria RUÍZ Evone S. GHALY |
| author_facet | Gloria RUÍZ Evone S. GHALY |
| author_sort | Gloria RUÍZ |
| collection | DOAJ |
| description | The objective of this research is a bioadhesive two layers controlled release tablets. The drug
release and the physical properties of tablet formulations using two polymers (Carrageenan 934
and Eudragit RL PO) at three levels and at a combination of different ratios of the two polymers
were evaluated. Formulation containing 40% total polymer level and a ratio of 1 Carrageenan to
1 Eudragit RLPO was the best formulationa. This formulation was tested in different dissolution
medium and at different rotational speed. The drug release was 96.3% in phosphate buffer pH
7.4; 59.1% in 0.1 N HCl and 46.4% in distilled water.
This study demonstrates the significance of the combination of two polymers for obtaining
controlled release bioadhesive matrix and enhancing the characteristic of each polymer. |
| first_indexed | 2024-12-19T02:06:41Z |
| format | Article |
| id | doaj.art-80e9f4ca6b6749d4880ca14fe116d7f2 |
| institution | Directory Open Access Journal |
| issn | 0121-4004 2145-2660 |
| language | English |
| last_indexed | 2024-12-19T02:06:41Z |
| publishDate | 2009-02-01 |
| publisher | Universidad de Antioquia |
| record_format | Article |
| series | Vitae |
| spelling | doaj.art-80e9f4ca6b6749d4880ca14fe116d7f22022-12-21T20:40:54ZengUniversidad de AntioquiaVitae0121-40042145-26602009-02-01131MUCOADHESIVE DELIVERY SYSTEMS USING CARRAGEENAN AND EUDRAGIT RLPOGloria RUÍZEvone S. GHALYThe objective of this research is a bioadhesive two layers controlled release tablets. The drug release and the physical properties of tablet formulations using two polymers (Carrageenan 934 and Eudragit RL PO) at three levels and at a combination of different ratios of the two polymers were evaluated. Formulation containing 40% total polymer level and a ratio of 1 Carrageenan to 1 Eudragit RLPO was the best formulationa. This formulation was tested in different dissolution medium and at different rotational speed. The drug release was 96.3% in phosphate buffer pH 7.4; 59.1% in 0.1 N HCl and 46.4% in distilled water. This study demonstrates the significance of the combination of two polymers for obtaining controlled release bioadhesive matrix and enhancing the characteristic of each polymer.https://revistas.udea.edu.co/index.php/vitae/article/view/508Carrageenan matriceseudragit RLPO matriceschlorpheniramine maleatebioadhesionsustained releasecontrolled release |
| spellingShingle | Gloria RUÍZ Evone S. GHALY MUCOADHESIVE DELIVERY SYSTEMS USING CARRAGEENAN AND EUDRAGIT RLPO Vitae Carrageenan matrices eudragit RLPO matrices chlorpheniramine maleate bioadhesion sustained release controlled release |
| title | MUCOADHESIVE DELIVERY SYSTEMS USING CARRAGEENAN AND EUDRAGIT RLPO |
| title_full | MUCOADHESIVE DELIVERY SYSTEMS USING CARRAGEENAN AND EUDRAGIT RLPO |
| title_fullStr | MUCOADHESIVE DELIVERY SYSTEMS USING CARRAGEENAN AND EUDRAGIT RLPO |
| title_full_unstemmed | MUCOADHESIVE DELIVERY SYSTEMS USING CARRAGEENAN AND EUDRAGIT RLPO |
| title_short | MUCOADHESIVE DELIVERY SYSTEMS USING CARRAGEENAN AND EUDRAGIT RLPO |
| title_sort | mucoadhesive delivery systems using carrageenan and eudragit rlpo |
| topic | Carrageenan matrices eudragit RLPO matrices chlorpheniramine maleate bioadhesion sustained release controlled release |
| url | https://revistas.udea.edu.co/index.php/vitae/article/view/508 |
| work_keys_str_mv | AT gloriaruiz mucoadhesivedeliverysystemsusingcarrageenanandeudragitrlpo AT evonesghaly mucoadhesivedeliverysystemsusingcarrageenanandeudragitrlpo |