Recombination accelerates adaptation on a large-scale empirical fitness landscape in HIV-1.
Recombination has the potential to facilitate adaptation. In spite of the substantial body of theory on the impact of recombination on the evolutionary dynamics of adapting populations, empirical evidence to test these theories is still scarce. We examined the effect of recombination on adaptation o...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-06-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC4072600?pdf=render |
| _version_ | 1818991355219673088 |
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| author | Danesh Moradigaravand Roger Kouyos Trevor Hinkley Mojgan Haddad Christos J Petropoulos Jan Engelstädter Sebastian Bonhoeffer |
| author_facet | Danesh Moradigaravand Roger Kouyos Trevor Hinkley Mojgan Haddad Christos J Petropoulos Jan Engelstädter Sebastian Bonhoeffer |
| author_sort | Danesh Moradigaravand |
| collection | DOAJ |
| description | Recombination has the potential to facilitate adaptation. In spite of the substantial body of theory on the impact of recombination on the evolutionary dynamics of adapting populations, empirical evidence to test these theories is still scarce. We examined the effect of recombination on adaptation on a large-scale empirical fitness landscape in HIV-1 based on in vitro fitness measurements. Our results indicate that recombination substantially increases the rate of adaptation under a wide range of parameter values for population size, mutation rate and recombination rate. The accelerating effect of recombination is stronger for intermediate mutation rates but increases in a monotonic way with the recombination rates and population sizes that we examined. We also found that both fitness effects of individual mutations and epistatic fitness interactions cause recombination to accelerate adaptation. The estimated epistasis in the adapting populations is significantly negative. Our results highlight the importance of recombination in the evolution of HIV-I. |
| first_indexed | 2024-12-20T20:08:57Z |
| format | Article |
| id | doaj.art-80ea57ea827046ff8ff638ad9a315ad4 |
| institution | Directory Open Access Journal |
| issn | 1553-7390 1553-7404 |
| language | English |
| last_indexed | 2024-12-20T20:08:57Z |
| publishDate | 2014-06-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Genetics |
| spelling | doaj.art-80ea57ea827046ff8ff638ad9a315ad42022-12-21T19:27:51ZengPublic Library of Science (PLoS)PLoS Genetics1553-73901553-74042014-06-01106e100443910.1371/journal.pgen.1004439Recombination accelerates adaptation on a large-scale empirical fitness landscape in HIV-1.Danesh MoradigaravandRoger KouyosTrevor HinkleyMojgan HaddadChristos J PetropoulosJan EngelstädterSebastian BonhoefferRecombination has the potential to facilitate adaptation. In spite of the substantial body of theory on the impact of recombination on the evolutionary dynamics of adapting populations, empirical evidence to test these theories is still scarce. We examined the effect of recombination on adaptation on a large-scale empirical fitness landscape in HIV-1 based on in vitro fitness measurements. Our results indicate that recombination substantially increases the rate of adaptation under a wide range of parameter values for population size, mutation rate and recombination rate. The accelerating effect of recombination is stronger for intermediate mutation rates but increases in a monotonic way with the recombination rates and population sizes that we examined. We also found that both fitness effects of individual mutations and epistatic fitness interactions cause recombination to accelerate adaptation. The estimated epistasis in the adapting populations is significantly negative. Our results highlight the importance of recombination in the evolution of HIV-I.http://europepmc.org/articles/PMC4072600?pdf=render |
| spellingShingle | Danesh Moradigaravand Roger Kouyos Trevor Hinkley Mojgan Haddad Christos J Petropoulos Jan Engelstädter Sebastian Bonhoeffer Recombination accelerates adaptation on a large-scale empirical fitness landscape in HIV-1. PLoS Genetics |
| title | Recombination accelerates adaptation on a large-scale empirical fitness landscape in HIV-1. |
| title_full | Recombination accelerates adaptation on a large-scale empirical fitness landscape in HIV-1. |
| title_fullStr | Recombination accelerates adaptation on a large-scale empirical fitness landscape in HIV-1. |
| title_full_unstemmed | Recombination accelerates adaptation on a large-scale empirical fitness landscape in HIV-1. |
| title_short | Recombination accelerates adaptation on a large-scale empirical fitness landscape in HIV-1. |
| title_sort | recombination accelerates adaptation on a large scale empirical fitness landscape in hiv 1 |
| url | http://europepmc.org/articles/PMC4072600?pdf=render |
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