Epsilon-Globin HBE1 Enhances Radiotherapy Resistance by Down-Regulating BCL11A in Colorectal Cancer Cells

Epsilon-Globin HBE1 Enhances Radiotherapy Resistance by Down-Regulating BCL11A in Colorectal Cancer Cells

Resistance to radiotherapy is considered an important obstacle in the treatment of colorectal cancer. However, the mechanisms that enable tumor cells to tolerate the effects of radiation remain unclear. Moreover, radiotherapy causes accumulated mutations in transcription factors, which can lead to c...

Full description

Bibliographic Details
Main Authors:	Sang Yoon Park, Seon-Jin Lee, Hee Jun Cho, Jong-Tae Kim, Hyang Ran Yoon, Kyung Ho Lee, Bo Yeon Kim, Younghee Lee, Hee Gu Lee
Format:	Article
Language:	English
Published:	MDPI AG 2019-04-01
Series:	Cancers
Subjects:	ER stress HBE1 BCL11A JNK radioresistant oxidative stress cell cycle arrest
Online Access:	https://www.mdpi.com/2072-6694/11/4/498

Similar Items

HBeAg-Negative/Anti-HBe-Positive Chronic Hepatitis B: A 40-Year-Old History
by: Ferruccio Bonino, et al.
Published: (2022-07-01)

Study of hepatic histomorphology in HBeAg+ and HBeAg− patients with CHB: Experience from Bangladesh
by: Ayub Al Mamun, et al.
Published: (2013-01-01)

HbE and HbF levels in HbE/βO-thalassemia are heterogeneous
by: Thanusak Tatu, et al.
Published: (2011-01-01)

ABT-737 reverses the acquired radioresistance of breast cancer cells by targeting Bcl-2 and Bcl-xL
by: Li Ji-Yu, et al.
Published: (2012-12-01)

Efficacy of a combination of HBV RNA and HBeAg in predicting HBeAg seroconversion in patients treated with entecavir for 144 weeks
by: Xiaomei Wang, et al.
Published: (2020-10-01)

Molecular understanding of unusual HbE-β+-thalassemia with Hb phenotype similar to HbE heterozygote: simple and rapid differentiation using HbE levels
by: Wittaya Jomoui, et al.
Published: (2023-12-01)

Oxygen-Glucose-Deprivation/Reoxygenation-Induced Autophagic Cell Death Depends on JNK-Mediated Phosphorylation of Bcl-2
by: Jin Fan, et al.
Published: (2016-03-01)

Differential regulation of plasma proteins between members of a family with homozygous HbE and HbEβ-thalassemia
by: Suchismita Halder, et al.
Published: (2014-09-01)

Metformin enhances the cytotoxic effect of nilotinib and overcomes nilotinib resistance in chronic myeloid leukemia cells
by: Yoo Jin Na, et al.
Published: (2021-03-01)

Cellular Stress Responses in Radiotherapy
by: Wanyeon Kim, et al.
Published: (2019-09-01)

The Complex Role of HBeAg and Its Precursors in the Pathway to Hepatocellular Carcinoma
by: Kiyasha Padarath, et al.
Published: (2023-03-01)

Posterior transverse interarch discrepancy on HbE β thalassemia patients
by: Yuniar Zen, et al.
Published: (2011-03-01)

A novel nomogram for predicting HBeAg seroclearance in HBeAg-positive chronic hepatitis B patients treated with nucleos(t)ide analogues
by: Yan Gu, et al.
Published: (2024-01-01)

The case report: Effect of red blood cell transfusion on hemoglobin (Hb) analysis of β0-Thalassemia/HbE disease and homozygous HbE
by: Sakorn Pornprasert
Published: (2017-01-01)

Correlations of HBV Genotypes, Mutations Affecting HBeAg Expression and HBeAg/ anti-HBe Status in HBV Carriers
Published: (2006-01-01)

A Predictive Model to Evaluate the HbeAg Positivity of Chronic Hepatitis B Virus Patients in Clinics: A Cross-Sectional Study
by: Ning Wang, et al.
Published: (2022-09-01)

HBV pregenome RNA as a predictor of spontanous HBeAg seroconversion in HBeAg-positive chronic hepatitis B patients
by: Guangjun Song, et al.
Published: (2023-11-01)

HBeAg Levels Vary across the Different Stages of HBV Infection According to the Extent of Immunological Pressure and Are Associated with Therapeutic Outcome in the Setting of Immunosuppression-Driven HBV Reactivation
by: Lorenzo Piermatteo, et al.
Published: (2021-09-01)

Coexistence of HBsAg/Anti-HBs and HBeAg/Anti-HBe in Sudanese Patients with Chronic Hepatitis B Virus Infection: A Cross-Sectional Study
by: Taqwa Hashim, et al.
Published: (2023-12-01)

HBeAg mediates inflammatory functions of macrophages by TLR2 contributing to hepatic fibrosis
by: Xiaoyu Xie, et al.
Published: (2021-10-01)

Immunomodulatory Function of HBeAg Related to Short-Sighted Evolution, Transmissibility, and Clinical Manifestation of Hepatitis B Virus
by: Anna Kramvis, et al.
Published: (2018-10-01)

What is the reason of elevated alanine aminotransferase level in HBeAg negative patients with low viremia: NAFLD or chronic hepatitis?
by: Kadir Demir, et al.
Published: (2007-04-01)

A clinical study of hemoglobin E with special reference to serum ferritin level
by: Umesh Das, et al.
Published: (2015-01-01)

Roles of Bcl-2 and caspase-9 and -3 in CD30-induced human eosinophil apoptosis
by: Hye Jin Lee, et al.
Published: (2017-04-01)

Apigenin Induces Autophagy and Cell Death by Targeting EZH2 under Hypoxia Conditions in Gastric Cancer Cells
by: Tae Woo Kim, et al.
Published: (2021-12-01)

Regulation of the Autophagic Bcl-2/Beclin 1 Interaction
by: Geert Bultynck, et al.
Published: (2012-07-01)

Characterization of HBeAg-negative chronic hepatitis B in western Brazilian Amazonia
by: Flamir da Silva Victoria, et al.

Prevalence of HBV DNA in anti-HBe+ chronic HBV carriers in Babol, 2002
by: MR Hassanjani Roshan, et al.
Published: (2004-10-01)

Identification of a natural PLA2 inhibitor from the marine fungus Aspergillus sp. c1 for MAFLD treatment that suppressed lipotoxicity by inhibiting the IRE-1α/XBP-1s axis and JNK signaling
by: Yong Rao, et al.
Published: (2024-01-01)

Eupalinolide B inhibits hepatic carcinoma by inducing ferroptosis and ROS-ER-JNK pathway
by: Zhang Yonghui, et al.
Published: (2022-07-01)

Zyflamend induces apoptosis in pancreatic cancer cells via modulation of the JNK pathway
by: Dexter L. Puckett, et al.
Published: (2020-08-01)

The Bcl-2 protein: a prognostic indicator strongly related to ER and PR in breast cancer
by: Nurija Bilalović, et al.
Published: (2004-11-01)

Status of Hepatitis Be Antigen in Chronic Hepatitis B Patients from Various Regions of Pakistan
by: Agha Babar Hussain
Published: (2017-09-01)

Efficacy of 104-week Telbivudine-based optimization strategy in patients with HBeAg-negative chronic hepatitis B virus infections
by: Weiqiang Gan, et al.
Published: (2020-12-01)

Potent necrosis effect of methanethiol mediated by METTL7B enzyme bioactivation mechanism in 16HBE cell
by: Jinting Lei, et al.
Published: (2022-05-01)

Cellular heterogeneity in the 16HBE14o− airway epithelial line impacts biological readouts
by: Jenny L. Kerschner, et al.
Published: (2023-06-01)

Loss of BOK Has a Minor Impact on Acetaminophen Overdose-Induced Liver Damage in Mice
by: Samara Naim, et al.
Published: (2021-03-01)

Methylmercury Induces Mitochondria- and Endoplasmic Reticulum Stress-Dependent Pancreatic β-Cell Apoptosis via an Oxidative Stress-Mediated JNK Signaling Pathway
by: Ching-Yao Yang, et al.
Published: (2022-03-01)

Comparison of evolutionary patterns of different HBeAg status in HBV genotype B and C
by: Cai Ying, et al.
Published: (2015-12-01)

Genotype–phenotype correlation among beta-thalassemia and beta-thalassemia/HbE disease in Thai children: predictable clinical spectrum using genotypic analysis
by: Traivaree C, et al.
Published: (2018-04-01)