Oromandibular dystonia in Yemeni patients with khat chewing: a response to botulinum toxin treatment
Khat-(<em>Catha edulis</em>) related oromandibular dystonia is a difficult-to-treat subset of movement disorders that involve masticatory muscles with diverse and incapacitating manifestations. The aim of this study was to evaluate the efficacy of Botulinum toxin-type A therapy in khat c...
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| Format: | Article |
| Language: | English |
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MDPI AG
2014-06-01
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| Series: | Neurology International |
| Subjects: | |
| Online Access: | http://www.pagepress.org/journals/index.php/ni/article/view/5385 |
| _version_ | 1797934970232111104 |
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| author | Hatem S. Shehata Mohamed S. El-Tamawy Nevin Mohieldin Mohammed Edrees Saeed Bohlega |
| author_facet | Hatem S. Shehata Mohamed S. El-Tamawy Nevin Mohieldin Mohammed Edrees Saeed Bohlega |
| author_sort | Hatem S. Shehata |
| collection | DOAJ |
| description | Khat-(<em>Catha edulis</em>) related oromandibular dystonia is a difficult-to-treat subset of movement disorders that involve masticatory muscles with diverse and incapacitating manifestations. The aim of this study was to evaluate the efficacy of Botulinum toxin-type A therapy in khat chewer Yemeni patients with oromandibular dystonia. This prospective study included 18 khat-chewers Yemeni patients with refractory oromandibular dystonia, who were subjected to Botulinum toxin-A injection and followed up for 3 months thereafter. Primary efficacy outcome was the global impression scale, and secondary outcome measure was the Unified Dystonia Rating Scale. Patients showed improvement of both efficacy measures, maximum satisfactory responses were detected at the forth week after injection. No major adverse events were detected. Botulinum toxin-A is considered an effective and safe treatment option for refractory oromandibular dystonia in khat-chewers. |
| first_indexed | 2024-04-10T18:07:14Z |
| format | Article |
| id | doaj.art-80ed2ed6ff4544cdabe6d8850c79faab |
| institution | Directory Open Access Journal |
| issn | 2035-8385 2035-8377 |
| language | English |
| last_indexed | 2024-04-10T18:07:14Z |
| publishDate | 2014-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Neurology International |
| spelling | doaj.art-80ed2ed6ff4544cdabe6d8850c79faab2023-02-02T12:32:33ZengMDPI AGNeurology International2035-83852035-83772014-06-016210.4081/ni.2014.53852823Oromandibular dystonia in Yemeni patients with khat chewing: a response to botulinum toxin treatmentHatem S. Shehata0Mohamed S. El-Tamawy1Nevin Mohieldin2Mohammed Edrees3Saeed Bohlega4Department of Neurology, Cairo UniversityDepartment of Neurology, Cairo UniversityDepartment of Neurology, Cairo UniversityDepartment of Neurology, Cairo UniversityDepartment of Neurosciences, King Faisal Specialist Hospital and Research Centre, RiyadhKhat-(<em>Catha edulis</em>) related oromandibular dystonia is a difficult-to-treat subset of movement disorders that involve masticatory muscles with diverse and incapacitating manifestations. The aim of this study was to evaluate the efficacy of Botulinum toxin-type A therapy in khat chewer Yemeni patients with oromandibular dystonia. This prospective study included 18 khat-chewers Yemeni patients with refractory oromandibular dystonia, who were subjected to Botulinum toxin-A injection and followed up for 3 months thereafter. Primary efficacy outcome was the global impression scale, and secondary outcome measure was the Unified Dystonia Rating Scale. Patients showed improvement of both efficacy measures, maximum satisfactory responses were detected at the forth week after injection. No major adverse events were detected. Botulinum toxin-A is considered an effective and safe treatment option for refractory oromandibular dystonia in khat-chewers.http://www.pagepress.org/journals/index.php/ni/article/view/5385khat, oromandibular dystonia, Unified Dystonia Rating Scale, global impression scale, botulinum toxin |
| spellingShingle | Hatem S. Shehata Mohamed S. El-Tamawy Nevin Mohieldin Mohammed Edrees Saeed Bohlega Oromandibular dystonia in Yemeni patients with khat chewing: a response to botulinum toxin treatment Neurology International khat, oromandibular dystonia, Unified Dystonia Rating Scale, global impression scale, botulinum toxin |
| title | Oromandibular dystonia in Yemeni patients with khat chewing: a response to botulinum toxin treatment |
| title_full | Oromandibular dystonia in Yemeni patients with khat chewing: a response to botulinum toxin treatment |
| title_fullStr | Oromandibular dystonia in Yemeni patients with khat chewing: a response to botulinum toxin treatment |
| title_full_unstemmed | Oromandibular dystonia in Yemeni patients with khat chewing: a response to botulinum toxin treatment |
| title_short | Oromandibular dystonia in Yemeni patients with khat chewing: a response to botulinum toxin treatment |
| title_sort | oromandibular dystonia in yemeni patients with khat chewing a response to botulinum toxin treatment |
| topic | khat, oromandibular dystonia, Unified Dystonia Rating Scale, global impression scale, botulinum toxin |
| url | http://www.pagepress.org/journals/index.php/ni/article/view/5385 |
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