Higher Glycated Hemoglobin Level Is Associated with Increased Risk for Ischemic Stroke in Non-Diabetic Korean Male Adults
BackgroundThe role of glycated hemoglobin (HbA1c) in the prediction of ischemic stroke in non-diabetic subjects is not clear. We performed a study to analyze the role of HbA1c in the risk prediction of ischemic stroke in non-diabetic Korean males adult.MethodsA total of 307 non-diabetic male patient...
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| Format: | Article |
| Language: | English |
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Korean Diabetes Association
2011-10-01
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| Series: | Diabetes & Metabolism Journal |
| Subjects: | |
| Online Access: | http://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-35-551.pdf |
| _version_ | 1818178147375382528 |
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| author | Hyung Geun Oh Eun-Jung Rhee Tae-Woong Kim Kyung Bok Lee Jeong-Ho Park Kwang-Ik Yang Dushin Jeong Hyung-Kook Park |
| author_facet | Hyung Geun Oh Eun-Jung Rhee Tae-Woong Kim Kyung Bok Lee Jeong-Ho Park Kwang-Ik Yang Dushin Jeong Hyung-Kook Park |
| author_sort | Hyung Geun Oh |
| collection | DOAJ |
| description | BackgroundThe role of glycated hemoglobin (HbA1c) in the prediction of ischemic stroke in non-diabetic subjects is not clear. We performed a study to analyze the role of HbA1c in the risk prediction of ischemic stroke in non-diabetic Korean males adult.MethodsA total of 307 non-diabetic male patients with ischemic stroke were enrolled, and 253 age-matched control subjects without a history of diabetes, hypertension, or cardiovascular disease were selected from a Health Check-up database. Anthropometric measurement data, fasting glucose level, lipid profile, and HbA1c level were available for all subjects. Associations of the variables and the presence or absence of ischemic stroke were analyzed.ResultsThe ischemic stroke patient group had significantly higher HbA1c levels (5.8±0.5% vs. 5.5±0.5%, P<0.01) and mean systolic and diastolic blood pressure compared with the control group. Among the variables, smoking, low high density lipoprotein cholesterol, systolic blood pressure, and HbA1c were the significant determinants for ischemic stroke. The highest quartile of HbA1c showed a 9.6-fold increased odds ratio for ischemic stroke compared with the lowest quartile of HbA1c (odds ratio, 9.596; 95% confidence interval, 3.859 to 23.863, P<0.01). The proportion of ischemic stroke patients showed a significant trend for increment as the deciles of HbA1c increased (P for trend <0.01).ConclusionHigher HbA1c indicated a significantly increased risk for ischemic stroke after adjusting for other confounding variables in non-diabetic Korean adult males. HbA1c might have significance in predicting the risk for ischemic stroke even in the non-diabetic range. |
| first_indexed | 2024-12-11T20:43:21Z |
| format | Article |
| id | doaj.art-80ed32acf55f41afa18f39de0c838604 |
| institution | Directory Open Access Journal |
| issn | 2233-6079 2233-6087 |
| language | English |
| last_indexed | 2024-12-11T20:43:21Z |
| publishDate | 2011-10-01 |
| publisher | Korean Diabetes Association |
| record_format | Article |
| series | Diabetes & Metabolism Journal |
| spelling | doaj.art-80ed32acf55f41afa18f39de0c8386042022-12-22T00:51:26ZengKorean Diabetes AssociationDiabetes & Metabolism Journal2233-60792233-60872011-10-0135555155710.4093/dmj.2011.35.5.5512665Higher Glycated Hemoglobin Level Is Associated with Increased Risk for Ischemic Stroke in Non-Diabetic Korean Male AdultsHyung Geun OhEun-Jung RheeTae-Woong KimKyung Bok LeeJeong-Ho ParkKwang-Ik YangDushin JeongHyung-Kook ParkBackgroundThe role of glycated hemoglobin (HbA1c) in the prediction of ischemic stroke in non-diabetic subjects is not clear. We performed a study to analyze the role of HbA1c in the risk prediction of ischemic stroke in non-diabetic Korean males adult.MethodsA total of 307 non-diabetic male patients with ischemic stroke were enrolled, and 253 age-matched control subjects without a history of diabetes, hypertension, or cardiovascular disease were selected from a Health Check-up database. Anthropometric measurement data, fasting glucose level, lipid profile, and HbA1c level were available for all subjects. Associations of the variables and the presence or absence of ischemic stroke were analyzed.ResultsThe ischemic stroke patient group had significantly higher HbA1c levels (5.8±0.5% vs. 5.5±0.5%, P<0.01) and mean systolic and diastolic blood pressure compared with the control group. Among the variables, smoking, low high density lipoprotein cholesterol, systolic blood pressure, and HbA1c were the significant determinants for ischemic stroke. The highest quartile of HbA1c showed a 9.6-fold increased odds ratio for ischemic stroke compared with the lowest quartile of HbA1c (odds ratio, 9.596; 95% confidence interval, 3.859 to 23.863, P<0.01). The proportion of ischemic stroke patients showed a significant trend for increment as the deciles of HbA1c increased (P for trend <0.01).ConclusionHigher HbA1c indicated a significantly increased risk for ischemic stroke after adjusting for other confounding variables in non-diabetic Korean adult males. HbA1c might have significance in predicting the risk for ischemic stroke even in the non-diabetic range.http://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-35-551.pdfGlycated hemoglobinKoreansStroke |
| spellingShingle | Hyung Geun Oh Eun-Jung Rhee Tae-Woong Kim Kyung Bok Lee Jeong-Ho Park Kwang-Ik Yang Dushin Jeong Hyung-Kook Park Higher Glycated Hemoglobin Level Is Associated with Increased Risk for Ischemic Stroke in Non-Diabetic Korean Male Adults Diabetes & Metabolism Journal Glycated hemoglobin Koreans Stroke |
| title | Higher Glycated Hemoglobin Level Is Associated with Increased Risk for Ischemic Stroke in Non-Diabetic Korean Male Adults |
| title_full | Higher Glycated Hemoglobin Level Is Associated with Increased Risk for Ischemic Stroke in Non-Diabetic Korean Male Adults |
| title_fullStr | Higher Glycated Hemoglobin Level Is Associated with Increased Risk for Ischemic Stroke in Non-Diabetic Korean Male Adults |
| title_full_unstemmed | Higher Glycated Hemoglobin Level Is Associated with Increased Risk for Ischemic Stroke in Non-Diabetic Korean Male Adults |
| title_short | Higher Glycated Hemoglobin Level Is Associated with Increased Risk for Ischemic Stroke in Non-Diabetic Korean Male Adults |
| title_sort | higher glycated hemoglobin level is associated with increased risk for ischemic stroke in non diabetic korean male adults |
| topic | Glycated hemoglobin Koreans Stroke |
| url | http://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-35-551.pdf |
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