Treatment approach in chronic hepatitis C infection
Purpose: We aimed to evaluate retrospectively the results of treatment of patients with chronic hepatitis C in our clinic.Material and Methods: We evaluated the treatment results of 109 patients who treated with the diagnosis of chronic hepatitis C between the years of 2003-2015 in our clinic.Result...
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| Format: | Article |
| Language: | English |
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Cukurova University
2016-06-01
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| Series: | Cukurova Medical Journal |
| Subjects: | |
| Online Access: | https://dergipark.org.tr/tr/download/article-file/206130 |
| _version_ | 1797919585980121088 |
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| author | Aslıhan Ulu Ayşe İnal Behice Kurtaran Ferit Kuşçu Hasan Aksu Süheyla Kömür Yeşim Taşova |
| author_facet | Aslıhan Ulu Ayşe İnal Behice Kurtaran Ferit Kuşçu Hasan Aksu Süheyla Kömür Yeşim Taşova |
| author_sort | Aslıhan Ulu |
| collection | DOAJ |
| description | Purpose: We aimed to evaluate retrospectively the results of treatment of patients with chronic hepatitis C in our clinic.Material and Methods: We evaluated the treatment results of 109 patients who treated with the diagnosis of chronic hepatitis C between the years of 2003-2015 in our clinic.Results: The 52.3% of the patients were male, the mean age was 52.3, mean ALT value 58.3 IU/ml and average HCV-RNA levels was 3,7x106 IU/ml. Previous treatment history in 47 patients (43%) was available. Eigthy-one patients (74.3%) received treatment of pegylated interferon and ribavirin and 28 patients(25.7%) received combination of pegylated interferon, ribavirin and telaprevir. Early virologic response were obtained in 99(90.8%) of 109 patients. Sustained virologic response was more higher in patients who achieved early virologic response. Sustained viralogic response in group of PegIFN/R was %74.1 and in group of PegIFN/R/T was 76.9%. At least one of complaints as rash, itching, taste disorder and anorectal pain were observed in PegIFN/R/T group. All patients had anemia as the most common hematologic side-effect. Depressive symptoms was observed in 19% of patients.Conclusion: With available treatment options in our country, patients who can not be achieved to SVR rates are available. There is a need for new antiviral drugs that used in the world for the patients infected with genotype 1 who had unsuccessful treatment. |
| first_indexed | 2024-04-10T13:47:52Z |
| format | Article |
| id | doaj.art-80ed8ce16da941048fcc444841e7fba7 |
| institution | Directory Open Access Journal |
| issn | 2602-3040 |
| language | English |
| last_indexed | 2024-04-10T13:47:52Z |
| publishDate | 2016-06-01 |
| publisher | Cukurova University |
| record_format | Article |
| series | Cukurova Medical Journal |
| spelling | doaj.art-80ed8ce16da941048fcc444841e7fba72023-02-15T16:10:54ZengCukurova UniversityCukurova Medical Journal2602-30402016-06-0141234234648Treatment approach in chronic hepatitis C infectionAslıhan UluAyşe İnalBehice KurtaranFerit KuşçuHasan AksuSüheyla KömürYeşim TaşovaPurpose: We aimed to evaluate retrospectively the results of treatment of patients with chronic hepatitis C in our clinic.Material and Methods: We evaluated the treatment results of 109 patients who treated with the diagnosis of chronic hepatitis C between the years of 2003-2015 in our clinic.Results: The 52.3% of the patients were male, the mean age was 52.3, mean ALT value 58.3 IU/ml and average HCV-RNA levels was 3,7x106 IU/ml. Previous treatment history in 47 patients (43%) was available. Eigthy-one patients (74.3%) received treatment of pegylated interferon and ribavirin and 28 patients(25.7%) received combination of pegylated interferon, ribavirin and telaprevir. Early virologic response were obtained in 99(90.8%) of 109 patients. Sustained virologic response was more higher in patients who achieved early virologic response. Sustained viralogic response in group of PegIFN/R was %74.1 and in group of PegIFN/R/T was 76.9%. At least one of complaints as rash, itching, taste disorder and anorectal pain were observed in PegIFN/R/T group. All patients had anemia as the most common hematologic side-effect. Depressive symptoms was observed in 19% of patients.Conclusion: With available treatment options in our country, patients who can not be achieved to SVR rates are available. There is a need for new antiviral drugs that used in the world for the patients infected with genotype 1 who had unsuccessful treatment.https://dergipark.org.tr/tr/download/article-file/206130kronik hepatit c genotip 1 kalıcı virolojik yanıt |
| spellingShingle | Aslıhan Ulu Ayşe İnal Behice Kurtaran Ferit Kuşçu Hasan Aksu Süheyla Kömür Yeşim Taşova Treatment approach in chronic hepatitis C infection Cukurova Medical Journal kronik hepatit c genotip 1 kalıcı virolojik yanıt |
| title | Treatment approach in chronic hepatitis C infection |
| title_full | Treatment approach in chronic hepatitis C infection |
| title_fullStr | Treatment approach in chronic hepatitis C infection |
| title_full_unstemmed | Treatment approach in chronic hepatitis C infection |
| title_short | Treatment approach in chronic hepatitis C infection |
| title_sort | treatment approach in chronic hepatitis c infection |
| topic | kronik hepatit c genotip 1 kalıcı virolojik yanıt |
| url | https://dergipark.org.tr/tr/download/article-file/206130 |
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