Influence of bisoprolol and nebivolol on the regulatory-adaptive status of patients with diastolic chronic heart failure
Background. Chronic heart failure (CHF) is the most common outcome of cardiovascular disease, of hypertension disease (HD). Beta-blockers contribute to the correction of hypertension, reduce heart remodeling, slow the progression of CHF. At the same time, bisoprolol and nebivolol differing pharmacoc...
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| Format: | Article |
| Language: | English |
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Concilium Medicum
2022-12-01
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| Series: | КардиоСоматика |
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| Online Access: | https://cardiosomatics.orscience.ru/2221-7185/article/viewFile/108297/pdf |
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| author | Pavel V. Khilkevich Vitalii G. Tregubov Iosif Z. Shubitidze Anna V. Tregubova |
| author_facet | Pavel V. Khilkevich Vitalii G. Tregubov Iosif Z. Shubitidze Anna V. Tregubova |
| author_sort | Pavel V. Khilkevich |
| collection | DOAJ |
| description | Background. Chronic heart failure (CHF) is the most common outcome of cardiovascular disease, of hypertension disease (HD). Beta-blockers contribute to the correction of hypertension, reduce heart remodeling, slow the progression of CHF. At the same time, bisoprolol and nebivolol differing pharmacochemical properties can have a multidirectional effect on the regulatory-adaptive status (RAS).
Aim. To determine the effect of bisoprolol or nebivolol therapy on the RAS of patients with diastolic CHF on the background of HD III stage.
Material and methods. The study involved 68 patients with diastolic CHF who were randomized into two groups for treatment with bisoprolol or nebivolol. As part of the combination therapy, patients were administered quinapril was prescribed (13.52.5 mg/day, n=34 and 12.82.8 mg/day, n=34), and if indicated, acetylsalicylic acid, atorvastatin. Initially and after 24 weeks of therapy were carried out: quantitative assessment of RAS, echocardiography, treadmill test, six-minute walking test, subjective assessment of quality of life, determination of the level of N-terminal propeptide of brain natriuretic hormone in blood plasma, daily monitoring of blood pressure.
Results. Both schemes of combined therapy comparably improved the structural and functional state of the heart, controlled arterial hypertension. In comparison with bisoprolol, nebivolol differed positive impact on RAS, more increased tolerance to physical activity and improved quality of life.
Conclusion. In patients with diastolic CHF and HD III stage, the use of nebivolol in combination therapy may be preferable due to the positive effect on RAS, in comparison with bisoprolol. |
| first_indexed | 2024-04-13T06:24:47Z |
| format | Article |
| id | doaj.art-80efd6901bb74277897c8e4f97542936 |
| institution | Directory Open Access Journal |
| issn | 2221-7185 2658-5707 |
| language | English |
| last_indexed | 2024-04-13T06:24:47Z |
| publishDate | 2022-12-01 |
| publisher | Concilium Medicum |
| record_format | Article |
| series | КардиоСоматика |
| spelling | doaj.art-80efd6901bb74277897c8e4f975429362022-12-22T02:58:28ZengConcilium MedicumКардиоСоматика2221-71852658-57072022-12-011329410010.17816/CS10829776511Influence of bisoprolol and nebivolol on the regulatory-adaptive status of patients with diastolic chronic heart failurePavel V. Khilkevich0Vitalii G. Tregubov1https://orcid.org/0000-0003-0635-3598Iosif Z. Shubitidze2https://orcid.org/0000-0002-4588-9515Anna V. Tregubova3Kuban State Medical UniversityKuban State Medical UniversityRegional Clinical Hospital №2, KrasnodarKuban State Medical UniversityBackground. Chronic heart failure (CHF) is the most common outcome of cardiovascular disease, of hypertension disease (HD). Beta-blockers contribute to the correction of hypertension, reduce heart remodeling, slow the progression of CHF. At the same time, bisoprolol and nebivolol differing pharmacochemical properties can have a multidirectional effect on the regulatory-adaptive status (RAS). Aim. To determine the effect of bisoprolol or nebivolol therapy on the RAS of patients with diastolic CHF on the background of HD III stage. Material and methods. The study involved 68 patients with diastolic CHF who were randomized into two groups for treatment with bisoprolol or nebivolol. As part of the combination therapy, patients were administered quinapril was prescribed (13.52.5 mg/day, n=34 and 12.82.8 mg/day, n=34), and if indicated, acetylsalicylic acid, atorvastatin. Initially and after 24 weeks of therapy were carried out: quantitative assessment of RAS, echocardiography, treadmill test, six-minute walking test, subjective assessment of quality of life, determination of the level of N-terminal propeptide of brain natriuretic hormone in blood plasma, daily monitoring of blood pressure. Results. Both schemes of combined therapy comparably improved the structural and functional state of the heart, controlled arterial hypertension. In comparison with bisoprolol, nebivolol differed positive impact on RAS, more increased tolerance to physical activity and improved quality of life. Conclusion. In patients with diastolic CHF and HD III stage, the use of nebivolol in combination therapy may be preferable due to the positive effect on RAS, in comparison with bisoprolol.https://cardiosomatics.orscience.ru/2221-7185/article/viewFile/108297/pdfregulatory adaptive statushypertensionbisoprololnebivolol |
| spellingShingle | Pavel V. Khilkevich Vitalii G. Tregubov Iosif Z. Shubitidze Anna V. Tregubova Influence of bisoprolol and nebivolol on the regulatory-adaptive status of patients with diastolic chronic heart failure КардиоСоматика regulatory adaptive status hypertension bisoprolol nebivolol |
| title | Influence of bisoprolol and nebivolol on the regulatory-adaptive status of patients with diastolic chronic heart failure |
| title_full | Influence of bisoprolol and nebivolol on the regulatory-adaptive status of patients with diastolic chronic heart failure |
| title_fullStr | Influence of bisoprolol and nebivolol on the regulatory-adaptive status of patients with diastolic chronic heart failure |
| title_full_unstemmed | Influence of bisoprolol and nebivolol on the regulatory-adaptive status of patients with diastolic chronic heart failure |
| title_short | Influence of bisoprolol and nebivolol on the regulatory-adaptive status of patients with diastolic chronic heart failure |
| title_sort | influence of bisoprolol and nebivolol on the regulatory adaptive status of patients with diastolic chronic heart failure |
| topic | regulatory adaptive status hypertension bisoprolol nebivolol |
| url | https://cardiosomatics.orscience.ru/2221-7185/article/viewFile/108297/pdf |
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