A longitudinal study of atrophy in amnestic mild cognitive impairment and normal aging revealed by cortical thickness.
In recent years, amnestic mild cognitive impairment (aMCI) has attracted significant attention as an indicator of high risk for Alzheimer's disease. An understanding of the pathology of aMCI may benefit the development of effective clinical treatments for dementia. In this work, we measured the...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23133666/pdf/?tool=EBI |
| _version_ | 1818435278280327168 |
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| author | Zhijun Yao Bin Hu Chuanjiang Liang Lina Zhao Mike Jackson Alzheimer's Disease Neuroimaging Initiative |
| author_facet | Zhijun Yao Bin Hu Chuanjiang Liang Lina Zhao Mike Jackson Alzheimer's Disease Neuroimaging Initiative |
| author_sort | Zhijun Yao |
| collection | DOAJ |
| description | In recent years, amnestic mild cognitive impairment (aMCI) has attracted significant attention as an indicator of high risk for Alzheimer's disease. An understanding of the pathology of aMCI may benefit the development of effective clinical treatments for dementia. In this work, we measured the cortical thickness of 109 aMCI subjects and 99 normal controls (NC) twice over two years. The longitudinal changes and the cross-sectional differences between the two types of participants were explored using the vertex thickness values. The thickness of the cortex in aMCI was found significantly reduced in both longitudinal and between-group comparisons, mainly in the temporal lobe, superolateral parietal lobe and some regions of the frontal cortices. Compared to NC, the aMCI showed a significantly high atrophy rate in the left lateral temporal lobe and left parahippocampal gyrus over two years. Additionally, a significant positive correlation between brain atrophy and the decline of Mini-Mental State Examination (MMSE) scores was also found in the left superior and left middle temporal gyrus in aMCI. These findings demonstrated specific longitudinal spatial patterns of cortical atrophy in aMCI and NC. The higher atrophy rate in aMCI might be responsible for the accelerated functional decline in the aMCI progression process. |
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| id | doaj.art-80f2ac7b7dfb4e97bcf63daaedddafd2 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T16:50:20Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-80f2ac7b7dfb4e97bcf63daaedddafd22022-12-21T22:54:04ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-01711e4897310.1371/journal.pone.0048973A longitudinal study of atrophy in amnestic mild cognitive impairment and normal aging revealed by cortical thickness.Zhijun YaoBin HuChuanjiang LiangLina ZhaoMike JacksonAlzheimer's Disease Neuroimaging InitiativeIn recent years, amnestic mild cognitive impairment (aMCI) has attracted significant attention as an indicator of high risk for Alzheimer's disease. An understanding of the pathology of aMCI may benefit the development of effective clinical treatments for dementia. In this work, we measured the cortical thickness of 109 aMCI subjects and 99 normal controls (NC) twice over two years. The longitudinal changes and the cross-sectional differences between the two types of participants were explored using the vertex thickness values. The thickness of the cortex in aMCI was found significantly reduced in both longitudinal and between-group comparisons, mainly in the temporal lobe, superolateral parietal lobe and some regions of the frontal cortices. Compared to NC, the aMCI showed a significantly high atrophy rate in the left lateral temporal lobe and left parahippocampal gyrus over two years. Additionally, a significant positive correlation between brain atrophy and the decline of Mini-Mental State Examination (MMSE) scores was also found in the left superior and left middle temporal gyrus in aMCI. These findings demonstrated specific longitudinal spatial patterns of cortical atrophy in aMCI and NC. The higher atrophy rate in aMCI might be responsible for the accelerated functional decline in the aMCI progression process.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23133666/pdf/?tool=EBI |
| spellingShingle | Zhijun Yao Bin Hu Chuanjiang Liang Lina Zhao Mike Jackson Alzheimer's Disease Neuroimaging Initiative A longitudinal study of atrophy in amnestic mild cognitive impairment and normal aging revealed by cortical thickness. PLoS ONE |
| title | A longitudinal study of atrophy in amnestic mild cognitive impairment and normal aging revealed by cortical thickness. |
| title_full | A longitudinal study of atrophy in amnestic mild cognitive impairment and normal aging revealed by cortical thickness. |
| title_fullStr | A longitudinal study of atrophy in amnestic mild cognitive impairment and normal aging revealed by cortical thickness. |
| title_full_unstemmed | A longitudinal study of atrophy in amnestic mild cognitive impairment and normal aging revealed by cortical thickness. |
| title_short | A longitudinal study of atrophy in amnestic mild cognitive impairment and normal aging revealed by cortical thickness. |
| title_sort | longitudinal study of atrophy in amnestic mild cognitive impairment and normal aging revealed by cortical thickness |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23133666/pdf/?tool=EBI |
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