Local Delivery of High-Dose Chondroitinase ABC in the Sub-Acute Stage Promotes Axonal Outgrowth and Functional Recovery after Complete Spinal Cord Transection.

Local Delivery of High-Dose Chondroitinase ABC in the Sub-Acute Stage Promotes Axonal Outgrowth and Functional Recovery after Complete Spinal Cord Transection.

Chondroitin sulfate proteoglycans (CSPGs) are glial scar-associated molecules considered axonal regeneration inhibitors and can be digested by chondroitinase ABC (ChABC) to promote axonal regeneration after spinal cord injury (SCI). We previously demonstrated that intrathecal delivery of low-dose Ch...

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Bibliographic Details
Main Authors: Chu-Hsun Cheng, Chi-Te Lin, Meng-Jen Lee, May-Jywan Tsai, Wen-Hung Huang, Ming-Chao Huang, Yi-Lo Lin, Ching-Jung Chen, Wen-Cheng Huang, Henrich Cheng
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4579094?pdf=render

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