Comparison of seven surrogate insulin resistance indexes for predicting the prevalence of carotid atherosclerosis in normal-weight individuals
IntroductionThe aim of this study was to assess the correlation between surrogate insulin resistance (IR) indexes and carotid atherosclerosis (CA) in normal-weight populations, as well as compared their ability to predict CA.MethodA total of 26,795 middle-aged and older adult individuals with normal...
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2023.1241523/full |
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| author | Zeyu Liu Bi Deng Qin Huang Ruxin Tu Fang Yu Jian Xia Jian Xia Jian Xia Jie Feng Jie Feng Jie Feng |
| author_facet | Zeyu Liu Bi Deng Qin Huang Ruxin Tu Fang Yu Jian Xia Jian Xia Jian Xia Jie Feng Jie Feng Jie Feng |
| author_sort | Zeyu Liu |
| collection | DOAJ |
| description | IntroductionThe aim of this study was to assess the correlation between surrogate insulin resistance (IR) indexes and carotid atherosclerosis (CA) in normal-weight populations, as well as compared their ability to predict CA.MethodA total of 26,795 middle-aged and older adult individuals with normal body weights were included. Triglyceride-glucose index (TyG), TyG-body mass index, TyG-waist circumference (TyG-WC), TyG-waist-to-height ratio (TyG-WHtR), visceral adiposity index, Chinese VAI (CVAI) and lipid accumulation product (LAP) were determined using established formulas. The associations between these surrogate indexes and CA were assessed using logistic regression models and restricted cubic spline (RCS) analysis. Receiver operating characteristic curves were utilized to compare the performance of these indexes for predicting CA.ResultThe levels of all seven surrogate indexes of IR were significantly higher in normal-weight individuals with CA than in those without CA (p < 0.001). In the full-adjusted model, only CVAI, TyG-WC, TyG-WHtR and LAP were significantly associated with CA, with the adjusted odds ratios (95% CI) of CA being 1.25 (1.20–1.30), 1.18 (1.14–1.23), 1.20 (1.16–1.25) and 1.25 (1.18–1.32) for each one standard deviation increase in CVAI, TyG-WC, TyG-WHtR and LAP, respectively. RCS analysis revealed a significant increase in the prevalence of CA among normal-weight individuals with CVAI >89.83, LAP >28.91, TyG-WHtR >4.42 and TyG-WC >704.93. The area under the curve for CVAI was significantly greater than for other indexes (p < 0.001).ConclusionCVAI, TyG-WC, TyG-WHtR and LAP were independently associated with the prevalence of CA. Specifically, CVAI may be the most appropriate predictor of CA in normal-weight individuals. |
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| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-03-12T11:42:38Z |
| publishDate | 2023-08-01 |
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| spelling | doaj.art-80f682d92a1640fab0c63decf96b80232023-08-31T13:30:55ZengFrontiers Media S.A.Frontiers in Public Health2296-25652023-08-011110.3389/fpubh.2023.12415231241523Comparison of seven surrogate insulin resistance indexes for predicting the prevalence of carotid atherosclerosis in normal-weight individualsZeyu Liu0Bi Deng1Qin Huang2Ruxin Tu3Fang Yu4Jian Xia5Jian Xia6Jian Xia7Jie Feng8Jie Feng9Jie Feng10Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Neurology, Peking University People's Hospital, Beijing, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaClinical Research Center for Cerebrovascular Disease of Hunan Province, Central South University, Changsha, Hunan, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaClinical Research Center for Cerebrovascular Disease of Hunan Province, Central South University, Changsha, Hunan, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaIntroductionThe aim of this study was to assess the correlation between surrogate insulin resistance (IR) indexes and carotid atherosclerosis (CA) in normal-weight populations, as well as compared their ability to predict CA.MethodA total of 26,795 middle-aged and older adult individuals with normal body weights were included. Triglyceride-glucose index (TyG), TyG-body mass index, TyG-waist circumference (TyG-WC), TyG-waist-to-height ratio (TyG-WHtR), visceral adiposity index, Chinese VAI (CVAI) and lipid accumulation product (LAP) were determined using established formulas. The associations between these surrogate indexes and CA were assessed using logistic regression models and restricted cubic spline (RCS) analysis. Receiver operating characteristic curves were utilized to compare the performance of these indexes for predicting CA.ResultThe levels of all seven surrogate indexes of IR were significantly higher in normal-weight individuals with CA than in those without CA (p < 0.001). In the full-adjusted model, only CVAI, TyG-WC, TyG-WHtR and LAP were significantly associated with CA, with the adjusted odds ratios (95% CI) of CA being 1.25 (1.20–1.30), 1.18 (1.14–1.23), 1.20 (1.16–1.25) and 1.25 (1.18–1.32) for each one standard deviation increase in CVAI, TyG-WC, TyG-WHtR and LAP, respectively. RCS analysis revealed a significant increase in the prevalence of CA among normal-weight individuals with CVAI >89.83, LAP >28.91, TyG-WHtR >4.42 and TyG-WC >704.93. The area under the curve for CVAI was significantly greater than for other indexes (p < 0.001).ConclusionCVAI, TyG-WC, TyG-WHtR and LAP were independently associated with the prevalence of CA. Specifically, CVAI may be the most appropriate predictor of CA in normal-weight individuals.https://www.frontiersin.org/articles/10.3389/fpubh.2023.1241523/fullsurrogate insulin resistance indexescarotid atherosclerosiscarotid intima-media thicknesscarotid plaquecarotid stenosisnormal-weight individuals |
| spellingShingle | Zeyu Liu Bi Deng Qin Huang Ruxin Tu Fang Yu Jian Xia Jian Xia Jian Xia Jie Feng Jie Feng Jie Feng Comparison of seven surrogate insulin resistance indexes for predicting the prevalence of carotid atherosclerosis in normal-weight individuals Frontiers in Public Health surrogate insulin resistance indexes carotid atherosclerosis carotid intima-media thickness carotid plaque carotid stenosis normal-weight individuals |
| title | Comparison of seven surrogate insulin resistance indexes for predicting the prevalence of carotid atherosclerosis in normal-weight individuals |
| title_full | Comparison of seven surrogate insulin resistance indexes for predicting the prevalence of carotid atherosclerosis in normal-weight individuals |
| title_fullStr | Comparison of seven surrogate insulin resistance indexes for predicting the prevalence of carotid atherosclerosis in normal-weight individuals |
| title_full_unstemmed | Comparison of seven surrogate insulin resistance indexes for predicting the prevalence of carotid atherosclerosis in normal-weight individuals |
| title_short | Comparison of seven surrogate insulin resistance indexes for predicting the prevalence of carotid atherosclerosis in normal-weight individuals |
| title_sort | comparison of seven surrogate insulin resistance indexes for predicting the prevalence of carotid atherosclerosis in normal weight individuals |
| topic | surrogate insulin resistance indexes carotid atherosclerosis carotid intima-media thickness carotid plaque carotid stenosis normal-weight individuals |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2023.1241523/full |
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