Targeting the gut microbiota with dietary fibers: a novel approach to prevent the development cardiovascular complications linked to systemic lupus erythematosus in a preclinical study
ABSTRACTThis study is to investigate whether dietary fiber intake prevents vascular and renal damage in a genetic mouse model of systemic lupus erythematosus (SLE), and the contribution of gut microbiota in the protective effects. Female NZBWF1 (SLE) mice were treated with resistant-starch (RS) or i...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Gut Microbes |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2023.2247053 |
| _version_ | 1797320563649150976 |
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| author | Javier Moleón Cristina González-Correa Iñaki Robles-Vera Sofía Miñano Néstor de la Visitación Antonio Manuel Barranco Natividad Martín-Morales Francisco O’Valle Laura Mayo-Martínez Antonia García Marta Toral Rosario Jiménez Miguel Romero Juan Duarte |
| author_facet | Javier Moleón Cristina González-Correa Iñaki Robles-Vera Sofía Miñano Néstor de la Visitación Antonio Manuel Barranco Natividad Martín-Morales Francisco O’Valle Laura Mayo-Martínez Antonia García Marta Toral Rosario Jiménez Miguel Romero Juan Duarte |
| author_sort | Javier Moleón |
| collection | DOAJ |
| description | ABSTRACTThis study is to investigate whether dietary fiber intake prevents vascular and renal damage in a genetic mouse model of systemic lupus erythematosus (SLE), and the contribution of gut microbiota in the protective effects. Female NZBWF1 (SLE) mice were treated with resistant-starch (RS) or inulin-type fructans (ITF). In addition, inoculation of fecal microbiota from these experimental groups to recipient normotensive female C57Bl/6J germ-free (GF) mice was performed. Both fiber treatments, especially RS, prevented the development of hypertension, renal injury, improved the aortic relaxation induced by acetylcholine, and the vascular oxidative stress. RS and ITF treatments increased the proportion of acetate- and butyrate-producing bacteria, respectively, improved colonic inflammation and integrity, endotoxemia, and decreased helper T (Th)17 proportion in mesenteric lymph nodes (MLNs), blood, and aorta in SLE mice. However, disease activity (splenomegaly and anti-ds-DNA) was unaffected by both fibers. T cell priming and Th17 differentiation in MLNs and increased Th17 infiltration was linked to aortic endothelial dysfunction and hypertension after inoculation of fecal microbiota from SLE mice to GF mice, without changes in proteinuria and autoimmunity. All these effects were lower in GF mice after fecal inoculation from fiber-treated SLE mice. In conclusion, these findings support that fiber consumption prevented the development of hypertension by rebalancing of dysfunctional gut-immune system-vascular wall axis in SLE. |
| first_indexed | 2024-03-08T04:41:00Z |
| format | Article |
| id | doaj.art-80f6f931713a4a0eae1385f63b15461c |
| institution | Directory Open Access Journal |
| issn | 1949-0976 1949-0984 |
| language | English |
| last_indexed | 2024-03-08T04:41:00Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj.art-80f6f931713a4a0eae1385f63b15461c2024-02-08T12:02:07ZengTaylor & Francis GroupGut Microbes1949-09761949-09842023-12-0115210.1080/19490976.2023.2247053Targeting the gut microbiota with dietary fibers: a novel approach to prevent the development cardiovascular complications linked to systemic lupus erythematosus in a preclinical studyJavier Moleón0Cristina González-Correa1Iñaki Robles-Vera2Sofía Miñano3Néstor de la Visitación4Antonio Manuel Barranco5Natividad Martín-Morales6Francisco O’Valle7Laura Mayo-Martínez8Antonia García9Marta Toral10Rosario Jiménez11Miguel Romero12Juan Duarte13Department of Pharmacology, School of Pharmacy and Center for Biomedical Research (CIBM), University of Granada, Granada, SpainDepartment of Pharmacology, School of Pharmacy and Center for Biomedical Research (CIBM), University of Granada, Granada, SpainCentro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, SpainDepartment of Pharmacology, School of Pharmacy and Center for Biomedical Research (CIBM), University of Granada, Granada, SpainDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USADepartment of Pharmacology, School of Pharmacy and Center for Biomedical Research (CIBM), University of Granada, Granada, SpainDepartment of Pathology, School of Medicine, Instituto de Biopatología y Medicina Regenerativa (IBIMER) University of Granada, Granada, SpainDepartment of Pathology, School of Medicine, Instituto de Biopatología y Medicina Regenerativa (IBIMER) University of Granada, Granada, SpainCentre for Metabolomics and Bioanalysis (CEMBIO), Faculty of Pharmacy, Universidad San Pablo CEU, CEU Universities. Campus Monteprincipe, Boadilla del Monte, San Pablo, SpainCentre for Metabolomics and Bioanalysis (CEMBIO), Faculty of Pharmacy, Universidad San Pablo CEU, CEU Universities. Campus Monteprincipe, Boadilla del Monte, San Pablo, SpainDepartment of Pharmacology, School of Pharmacy and Center for Biomedical Research (CIBM), University of Granada, Granada, SpainDepartment of Pharmacology, School of Pharmacy and Center for Biomedical Research (CIBM), University of Granada, Granada, SpainDepartment of Pharmacology, School of Pharmacy and Center for Biomedical Research (CIBM), University of Granada, Granada, SpainDepartment of Pharmacology, School of Pharmacy and Center for Biomedical Research (CIBM), University of Granada, Granada, SpainABSTRACTThis study is to investigate whether dietary fiber intake prevents vascular and renal damage in a genetic mouse model of systemic lupus erythematosus (SLE), and the contribution of gut microbiota in the protective effects. Female NZBWF1 (SLE) mice were treated with resistant-starch (RS) or inulin-type fructans (ITF). In addition, inoculation of fecal microbiota from these experimental groups to recipient normotensive female C57Bl/6J germ-free (GF) mice was performed. Both fiber treatments, especially RS, prevented the development of hypertension, renal injury, improved the aortic relaxation induced by acetylcholine, and the vascular oxidative stress. RS and ITF treatments increased the proportion of acetate- and butyrate-producing bacteria, respectively, improved colonic inflammation and integrity, endotoxemia, and decreased helper T (Th)17 proportion in mesenteric lymph nodes (MLNs), blood, and aorta in SLE mice. However, disease activity (splenomegaly and anti-ds-DNA) was unaffected by both fibers. T cell priming and Th17 differentiation in MLNs and increased Th17 infiltration was linked to aortic endothelial dysfunction and hypertension after inoculation of fecal microbiota from SLE mice to GF mice, without changes in proteinuria and autoimmunity. All these effects were lower in GF mice after fecal inoculation from fiber-treated SLE mice. In conclusion, these findings support that fiber consumption prevented the development of hypertension by rebalancing of dysfunctional gut-immune system-vascular wall axis in SLE.https://www.tandfonline.com/doi/10.1080/19490976.2023.2247053Hypertensionendothelial dysfunctionfibersgut dysbiosisimmune systemsystemic lupus erythematosus |
| spellingShingle | Javier Moleón Cristina González-Correa Iñaki Robles-Vera Sofía Miñano Néstor de la Visitación Antonio Manuel Barranco Natividad Martín-Morales Francisco O’Valle Laura Mayo-Martínez Antonia García Marta Toral Rosario Jiménez Miguel Romero Juan Duarte Targeting the gut microbiota with dietary fibers: a novel approach to prevent the development cardiovascular complications linked to systemic lupus erythematosus in a preclinical study Gut Microbes Hypertension endothelial dysfunction fibers gut dysbiosis immune system systemic lupus erythematosus |
| title | Targeting the gut microbiota with dietary fibers: a novel approach to prevent the development cardiovascular complications linked to systemic lupus erythematosus in a preclinical study |
| title_full | Targeting the gut microbiota with dietary fibers: a novel approach to prevent the development cardiovascular complications linked to systemic lupus erythematosus in a preclinical study |
| title_fullStr | Targeting the gut microbiota with dietary fibers: a novel approach to prevent the development cardiovascular complications linked to systemic lupus erythematosus in a preclinical study |
| title_full_unstemmed | Targeting the gut microbiota with dietary fibers: a novel approach to prevent the development cardiovascular complications linked to systemic lupus erythematosus in a preclinical study |
| title_short | Targeting the gut microbiota with dietary fibers: a novel approach to prevent the development cardiovascular complications linked to systemic lupus erythematosus in a preclinical study |
| title_sort | targeting the gut microbiota with dietary fibers a novel approach to prevent the development cardiovascular complications linked to systemic lupus erythematosus in a preclinical study |
| topic | Hypertension endothelial dysfunction fibers gut dysbiosis immune system systemic lupus erythematosus |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2023.2247053 |
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